D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa D-(+)-Cycloserine (CAS: 68-41-7) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, palo e nyane le e ngata e fumanehang.Reka D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | D-(+) -Cycloserine |
| Litlhaloso tse tšoanang | D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Boemo ba Setoko | E teng thepeng e teng ka lebenkeleng |
| Nomoro ea CAS | 68-41-7 |
| Foromo ea limolek'hule | C3H6N2O2 |
| Boima ba Molek'hule | 102.09 g/mol |
| Melting Point | 137 ℃ |
| E hloahloa | Ha e Mamelle Moeeng, Ha e Mamele Mocheso |
| Solubility | E qhibilihang ka Metsing.E qhibiliha hanyenyane ka Methanol le Propylene Glycol.Ha e qhibilihe ka har'a Chloroform le Ether. |
| Mocheso oa polokelo. | Sebaka se pholileng le se omileng (2~8℃) |
| COA & MSDS | E fumaneha |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo ea Crystalline e Bosoeu kapa Bosehla bo Bosehla | E lumellana |
| Potoloho e Khethehileng [α]20/D | +108.0° ho ea ho +114.0° (C=5, 2N NaOH) | +111,9° |
| Boitsebiso | 'Mala o Boputsoa o ile oa Hatela pele butle-butle | Mmala o Moputsoa |
| Lihlahisoa tsa Condensation | ≤0.80% (ho 286nm) | 0.08% |
| Tahlehelo ka ho Omisa | <1.00% | 0.38% |
| Masalla a ho Ignition | <0.50% | 0.10% |
| Litšepe tse boima (Pb) | ≤10ppm | <10ppm |
| Tšilafalo e Fetohang | ||
| - Methanol | ≤500ppm | <500ppm |
| - Acetone | ≤500ppm | <500ppm |
| Assay (Litlhahlobo tsa Lithibela-maenyane) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 ho isa ho 6.5 | 5.98 |
| FTIR | E lumellana | E lumellana |
| IR Spectrum | E lumellana | E lumellana |
| Sekhahla sa NMR | E lumellana | E lumellana |
| Qetello | Sehlahisoa sena ka tlhahlobo se lumellana le USP-35 e tloaelehileng | |
Cycloserine [68-41-7].
Cycloserine e na le matla a seng ka tlase ho 900µg ea C3H6N2O2 ka mg.
Ho paka le ho boloka-Ho boloka ka lijaneng tse thata.
USP Reference standards <11>-
USP Cycloserine RS
Identification-Hlakola hoo e ka bang 1 mg ho 10 ml ea 0.1 N sodium hydroxide.Ho 1 mL ea tharollo e hlahisoang eketsa 3 ml ea 1 N acetic acid le 1 ml ea motsoako, e lokiselitsoeng hora e le 'ngoe pele o sebelisoa, ea likarolo tse lekanang tsa sodium nitroprusside solution (1 ho 25) le 4 N sodium hydroxide:' mala o moputsoa butle-butle. ntshetsa pele.
Lihlahisoa tsa condensation-Ho monya ha eona (sheba Spectrophotometry le Light-Scattering <851>) ho 285 nm, e khethiloeng ka tharollo ea 0.1 N sodium hydroxide e nang le 0.40 mg ka mL ha e fete 0.80.
Potoloho e khethehileng <781S>: pakeng tsa 108° le 114°.Tharollo ea teko: 50 mg ka mL, ho 2 N sodium hydroxide.
Crystallinity <695>: e kopana le litlhoko
pH <791>: pakeng tsa 5.5 le 6.5, ka tharollo (1 ho 10).
Tahlehelo ha o omisa <731> -Omisa hoo e ka bang 100 mg ka botlolong ea capillar y-stoppered ka vacuum ka 60℃ bakeng sa lihora tse 3: e lahleheloa ke boima ba eona bo sa feteng 1.0%.
Masala ha ho behoa <281>: eseng ho feta 0.5%, masala a chesitsoeng a kolobisitsoe ka 2 ml ea nitric acid le marotholi a 5 a sulfuric acid.
Tlhahlobo-
pH 6.8 Phosphate buffer-Lokisetsa joalokaha ho laetsoe ho Buffer Solutions tlas'a Tharollo karolong ea Reagents, Indicators, and Solutions.
Mobile phase-Hlakola 0.5 g ea sodium 1-decanesulfonate ka 800 mL ea metsi, eketsa 50 ml ea acetonitrile le 5 ml ea glacial acetic acid, 'me u kopanye.Fetola ka 1 N sodium hydroxide ho pH ea 4.4.Sefe, le degas.Etsa litokiso ha ho hlokahala y (sheba Ho Sebetsa ha Sistimi tlas'a Chromatography <621>).
Tlhophiso e tloaelehileng-Qhololla ka mokhoa o nepahetseng tekanyo e lekantsoeng ea USP Cycloserine RS ka pH 6.8 Phosphate buffer ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 0.4 mg ka mL.
Boitokisetso ba tlhahlobo-Fetisetsa hoo e ka bang 20 mg ea Cycloserine, e lekantsoeng hantle, ho 50-mL volumetric flask, qhibiliha le ho hlapolla ka pH 6.8 Phosphate buffer ho bophahamo ba modumo, le ho kopanya.
Chromatographic system (sheba Chromatography <621>)-Mokelikeli oa chromatograph o na le mochine oa 219-nm le kholomo ea 4.6-mm × 25-cm e nang le 5- µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1 mL ka motsotso.Mocheso oa litšiea o bolokiloe hoo e ka bang 30 °.Chromatograph ea Boitokisetso ba Maemo, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Ts'ebetso: ntlha ea mohatla ha e fete 1.8;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 2.0%.
Ts'ebetso-Ka karohano ente livolume tse lekanang (tse ka bang 10 µL) tsa tokisetso e Tloaelehileng le boitokisetso ba Assay ka har'a chromatograph, rekota li-chromatogram, 'me u lekanye likarabelo tsa tlhoro bakeng sa cycloserine.Bala palo, ho µg, ea C3H6N2O2 ho mg e 'ngoe le e 'ngoe ea Cycloserine e nkiloeng ka foromo:
50,000(C/W)(rU / rS)
moo C e leng mahloriso, ka mg ka mL, ea USP Cycloserine RS ka ho lokisetsa Standard;W ke palo, ka mg, ea Cycloserine e nkiloeng ho lokisetsa ho lokisetsa Assay;'me rU le rS ke likarabelo tse phahameng ka ho fetisisa tsa cycloserine tse fumanoang ho tsoa ho Tokisetso ea Assay le ho hlophisoa ha Maemo, ka ho latellana.
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse tiisitsoeng sebakeng sa polokelo se pholileng le se omileng (2~8℃) hole le lintho tse sa lumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Fana ka lefatše ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Matshwao a Kotsi Xn - A Kotsi
Likhoutu tsa Kotsi
R5 - Ho futhumatsa ho ka baka ho phatloha
R20 - E kotsi ka ho hema
Tlhaloso ea Tšireletseho
S38 - Haeba moea o sa lekana, apara lisebelisoa tse loketseng tsa ho hema.
S36/37 - Apara liaparo tsa tšireletso tse loketseng le liatlana.
S24/25 - Qoba ho kopana le letlalo le mahlo.
WGK Jeremane 2
RTECS NY2975000
FLUKA BRAND F DIKHOUTU 10-23
HS Code 2941909099
D-(+)-Cycloserine (CAS: 68-41-7) e na le tlhaho e matla ea hygroscopic, e qhibiliha ka metsing, e qhibiliha hanyenyane ka joala bo tlaase, acetone le dioxane, 'me ha e khone ho qhibiliha ka chloroform le petroleum ether.E batla e tsitsitse ka tharollo ea alkaline 'me e senyeha ka potlako ka tharollo ea asiti kapa e sa nke lehlakore.E le lithibela-mafu tse pharalletseng, cycloserine e thibela libaktheria tse ngata tsa gram-positive le gram-negative, rickettsia le protozoa, ntle le lefuba la Mycobacterium. vinactane para-aminosalicylic acid, isoniazid le pyrazinamide.Cycloserine e hokahane hanyane le isoniazid ho thibela Mycobacterium tuberculosis H37RV, empa ha e kopane kapa hona ho hanyetsa streptomycin.Sehlahisoa ke bacteriostatic agent, 'me ka hona se ke ke sa ba le phello ea bactericidal le ha se eketsa lethal dose kapa ho lelefatsa nako ea ts'ebetso ka libaktheria.
Mokhoa oa ts'ebetso ea antibacterial ea D-cycloserine ke ho thibela biosynthesis ea peptidoglycan ea lebota la sele.Kaha ke analoge ea sebopeho sa D-alanine, D-cycloserine e ka thibela ka tlholisano mesebetsi ea alanine racemase le D-alanyl-D-alanine synthetase, e leng li-enzyme tse peli tsa bohlokoa ho peptidoglycan synthesis.D-cycloserine e bontša tšebetso e fokolang ea thibelo khahlanong le lefuba la Mycobacterium e leng feela 1/10 ho 1/20 ea streptomycin.Monyetla oa sehlahisoa ke hore se sebetsa hantle ho mafu a lefuba a hanyetsanang le lithethefatsi a Mycobacterium 'me ha a na monyetla oa ho baka khanyetso ea lithethefatsi.Sehlahisoa sena se ka sebelisoa le lithethefatsi tse ling tse thibelang lefuba ho phekola lefuba le bakoang ke lefuba le hanyetsanang le lithethefatsi Mycobacterium tuberculosis.
Cycloserine ke moriana oa mofuta oa bobeli o thibelang lefuba.E ka thibela kholo ea lefuba la Mycobacterium, empa phello e batla e fokola ho feta ea meriana ea pele.Ho sebetsa ha eona kalafong ea lefuba ho batla ho le tlase.Ho sebelisa moriana feela ho ka hlahisa khanyetso ea meriana, empa khanyetso e etsahala butle ha e bapisoa le ea litlhare tse ling tse thibelang lefuba.Ha ho na khanyetso pakeng tsa cycloserine le lithethefatsi tse ling tse thibelang lefuba.Mochini oa ts'ebetso ea eona ea antibacteria ke ho thibela ho qaptjoa ha peptidoglycan ea lebota la lisele tsa baktheria, ho baka sekoli ho meaho ea lerako la lisele.Karolo e ka sehloohong ea sebopeho sa lebota la baktheria ke peptidoglycan, e entsoeng ka N-acetylglucosamine (GNAc) le N-acetylmuramic acid (MNAc).N-acetylmuramic acid e amahanngoa le pentapeptide mme e hokahanya N-acetylglucosamine ka mokhoa o fokolang le o mong.Ho thehoa ha cytoplasmic peptidoglycan precursor ho ka 'na ha sitisoa ke cycloserine, kaha ea morao-rao e ka sitisa racemase le synthetase ea D-Alanine, kahoo e thibela ho thehoa ha N-acetylmuramic acid.
D-Cycloserine e ka fumanoa ka mokhoa oa ho belisa kapa ka ho kopanya ka ho toba.Libaktheria tse sebelisoang ha ho belisoa ke Actinomyces laven-dulae.Mokhoa oa ho belisa o na le dextrin, dextrose, starch, phofo ea soya, phofo ea tomoso, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate le oli ea soya.Ts'ebetsong ea ho kopanya, D-Cycloserine e fumanoa ho β-Aminooxy alanine ethyl ester hydrochloride ka ho itšoara ka potassium hydroxide ka tsela ea cyclization.
