Daptomycin CAS 103060-53-3 Purity ≥95.0% API Factory High Purity

Daptomycin (CAS: 103060-53-3) ke mofuta oa lithibela-mafu tsa cyclic lipopeptide tse nang le sebopeho sa libuka.E ntšitsoe ho moro oa Streptomyces fermentation.E ile ea sibolloa ke Eli Lilly Company lilemong tsa bo-1980, 'me e atlehile ho ntlafatsoa ka 1997 ke Cubist Pharmaceuticals.Ha e na sebopeho sa lik'hemik'hale tse ncha feela, empa hape e na le mokhoa oa ts'ebetso o fapaneng le oa lithibela-mafu tse amohetsoeng pele: e thibela sele ka ho sitisa ho tsamaisoa ha li-amino acid ka membrane ea sele, ka hona e thibela lerako la peptidoglycan biosynthesis le ho fetola sebopeho sa lisele. lera la sele.E ka senya ts'ebetso ea lera la baktheria likarolong tse ngata, 'me kapele ea bolaea libaktheria tsa gram-positive.Ntle le karolo ea ho sebetsa ho libaktheria tse amanang le gram-positive tse amanang le bongaka, haholo-holo, Daptomycin e na le ts'ebetso e matla ea ho phekola mefuta e ka thōko e bontšitseng matšoao a ho hanyetsa methicillin, vancomycin le linezolid.Thepa ena ke ea bohlokoa haholo ho bakuli ba nang le tšoaetso e matla.Ka September 2003, US Food and Drug Administration e amohetse ka lekhetlo la pele hore Daptomycin (CAS: 103060-53-3) e ka sebelisoa bakeng sa phekolo ea mafu a matla a letlalo.Ka March 2006, e ile ea amoheloa bakeng sa ho phekola mafu a tšoaetsanoang.Ka Pherekhong 2006, e amohetsoe ke Khomishene ea Europe bakeng sa kalafo ea mafu a itseng a rarahaneng a letlalo le lisele tse bonolo tse bakoang ke baktheria ea gram-positive.Ka la 6 Loetse 2007, Cubist Pharmaceuticals e phatlalalitse hore European Union e amohetse moriana oa eona oa antibacteria, Cubicin bakeng sa kalafo ea lefu la pelo le letona le bakoang ke mafu a Staphylococcus aureus le mafu a rarahaneng a amanang le letlalo le lisele tse bonolo tse bakoang ke Staphylococcus aureus.