Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor
Lihlahisoa tse Amanang le Baetsi ba Darunavir:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Lebitso la Lik'hemik'hale | Ethanolate ea Darunavir |
| Litlhaloso tse tšoanang | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R) -3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR) -hexahydrofuro [2,3-b]furan-3-yl ester compd.ka ethanol |
| Nomoro ea CAS | 635728-49-3 |
| Nomoro ea KAtse | RF-API69 |
| Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
| Foromo ea limolek'hule | C29H43N3O8S |
| Boima ba Molek'hule | 593.73 |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea Crystalline e tšoeu kapa e sa Tšoeu |
| Boitsebiso ba IR | E lumellana le Standard Spectrum |
| Phetoho e khethehileng | -0,5°~ +0,5° |
| Lintho Tse Amanang | (ka HPLC) |
| Ho Se hloeke ho hoholo ho Leng | ≤0.20% |
| Litšila ka Kakaretso | ≤0.50% |
| Metsi (KF) | ≤1.0% |
| Masalla a ho Ignition | ≤0.10% |
| Litšepe tse boima | ≤10ppm |
| Litaba tsa Ethanol | ≤7.5% (GC) |
| Metsoako e setseng | Methanol ≤0.30% |
| Bohloeki | ≥99.0% (HPLC) |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Darunavir Ethanolate (Prezista) ke inhibitor ea HIV protease inhibitor.Ho tsoa ho Darunavir, moloko oa bobeli oa HIV-1-protease inhibitor;ka sebopeho se ts'oanang le amprenavir.Antiviral.Ke sehlahisoa sa lipatlisiso se amanang le COVID19.Ka bomalimabe, DRV e na le ho qhibiliha ho tlase metsing le bioavailability e fokolang, ka hona e hloka tsamaiso ka tekanyo e batlang e phahame e le ho bontša katleho ea phekolo.Darunavir ke inhibitor e matla e matla e sebetsang khahlano le HIV-1 e itšehla thajana e nang le cytotoxicity e fokolang.Darunavir e theha maqhama a hydrogen le liathomo tsa ketane e kholo tse bolokiloeng tsa Asp29 le Asp30 ea protease.Litšebelisano tsena li hlahisoa e le tsa bohlokoa bakeng sa matla a motsoako ona khahlano le li-isolates tsa HIV tse hanyetsanang le li-multiple protease inhibitors.Phuputsong ea in vitro liseleng tsa MT-2, matla a darunavir a maholo ho feta a saquinavir, amprenavir, nelfinavir, indinavir, lopinavir le ritonavir.Darunavir e sebelisoa haholo-holo ke li-enzyme tsa hepatic cytochrome P450 (CYP), haholo-holo CYP3A.Tekanyo ea 'boosting' ea ritonavir e sebetsa e le inhibitor ea CYP3A, kahoo e eketsa bioavailability ea darunavir.Darunavir e ne e etselitsoe ho theha likamano tse matla le enzyme ea protease ho tsoa mefuteng e mengata ea HIV, ho kenyeletsoa le mathata a tsoang ho bakuli ba nang le phihlelo ea phekolo ba nang le multiple resistance mutati.
