Diethylphosphonoacetic Acid CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Diethylphosphonoacetic Acid

CAS: 3095-95-2

Bohloeki: >99.5% (HPLC)

Ponahalo: Mokelikeli o se nang 'mala

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Diethylphosphonoacetic acid
Litlhaloso tse tšoanang	2-(Diethoxyphosphoryl)acetic Acid;(Diethoxyphosphinyl)acetic Acid;Diethyl Carboxymethylphosphonate;NSC 272281
Nomoro ea CAS	3095-95-2
Nomoro ea KAtse	RF-PI2024
Boemo ba Setoko	Ka Setokong, Bokhoni ba Tlhahiso 30MT/Khoeli
Foromo ea limolek'hule	(C2H5O)2P(O)CH2CO2H
Boima ba Molek'hule	196.14
Ntlha e belang	150 ℃/0.05 mmHg (lit.)
Botenya	1.220 g/mL ho 25℃ (lit.)
Refractive Index	n20/D 1.445 (lit.)
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Mokelikeli o se nang Mebala
Boitsebiso (HPLC)	Nako ea ho boloka tlhōrō e kholo e fumanoeng ho tloha sampuling e ka hare ho 5% ea sampuli ea litšupiso.
Mokhoa oa Bohloeki / Analysis	>99.5% (HPLC)
Infrared Spectrum	E Ikamahanya le Sebopeho
Proton NMR Spectrum	E Ikamahanya le Sebopeho
Mongobo (KF)	<0.50%
Litšila ka Kakaretso	<0.50%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo ea Fluorinated, 25kg/ Drum, kapa ho latela tlhoko ea moreki

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

Diethylphosphonoacetic Acid (CAS: 3095-95-2), E sebetsa e le nucleophile bakeng sa likarabo tsa ho eketsa nucleophilic bakeng sa motsoako oa allene epoxides Reactant bakeng sa: Lithuto tsa Stereoselectivity tsa Staudinger reaction;Enantioselective sebopeho sa diols ka epoxidation le hydration reactions;Maikutlo a Horner-Wadsworth-Emmons;Remote chelation laoloa Ireland-Claisen rearrangement;karabelo ea Ugi-Dieckmann bakeng sa motsoako oa li-derivatives tsa tetramic acid;E sebelisoa ho etsa li-intermediate tsa phosphonoester bakeng sa karabelo ea intramolecular HEW.Diethylphosphonoacetic Acid ke karolo e bohareng ea Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate e amohetsoe ke Tsamaiso ea Lijo le Lithethefatsi ea US (FDA) ka 2013 bakeng sa kalafo ea mofetše o seng o monyane oa lisele tsa matšoafo (NSCLC).Ka ho khetheha, e ile ea amoheloa bakeng sa bakuli ba hlahisang lihlahala tsa metastatic NSCLC tse nang le ho tlosoa ha li-epidermal growth factor receptor (EGFR) kapa liphetoho tsa exon 21.Afatinib Dimaleate ke covalent inhibitor ea ErbB tyrosine kinases (tyk), e theolang taolo ea matšoao a ErbB ka tlamo e ke keng ea khutlisoa ea libaka tse tlamang tsa EGFR tyk.