Diflorasone Diacetate CAS 33564-31-7 Assay 97.0~103.0% Factory Corticosteroid

Diflorasone Diacetate [33564-31-7]
» Diflorasone Diacetate ha e na ka tlase ho karolo ea 97.0 le e seng ho feta 103.0 lekholong ea C26H32F2O7, e baloang ka motheo o omisitsoeng.
Ho paka le ho boloka-Ho boloka ka lijaneng tse thata.
USP Reference standards <11>-
USP Diflorasone Diacetate RS
Identification, Infrared Absorption <197M>.
Potoloho e khethehileng <781S>: pakeng tsa +58° le +68°.Tharollo ea teko: 20 mg, e sa omisitsoeng, ka mL, ka chloroform.
Tahlehelo ha o omisa <731> -O omise ka vacuum ka 60 ° le ka khatello e sa feteng 5 mm ea mer cury ka lihora tse 16: ha e lahleheloe ke ho feta 0.5% ea boima ba eona.
Masala a ho khantša <281>: eseng ho feta 0.5%
Bohloeki ba Chromatographic-
Mohato oa mobile le sistimi ea Chromatographic - Lokisetsa joalo ka ha ho laetsoe ho Assay.
Tharollo ea teko-Hlakola tekanyo e lekantsoeng e nepahetseng ea Diflorasone Diacetate ka chloroform e tletseng metsi ho fumana tharollo e nang le motsoako o ka bang 6 mg ka mL.
Ts'ebetso-Enta molumo (hoo e ka bang 10 µL) ea tharollo ea Teko ka har'a chromatograph, ngola chromatogram nako e lekanang le makhetlo a 5 nako ea ho boloka tlhoro e kholo, 'me u lekanye libaka tsa litlhoro tsohle.Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Diflorasone Diacetate e nkiloeng ka foromo:
100(ri / rs)
eo ho eona ri e leng sebaka se phahameng sa tšilafalo ka 'ngoe;'me rs ke kakaretso ea libaka tsa litlhōrō tsohle: ha ho na ho feta 1.0% ea litšila leha e le life tse fumanoang;mme ha se fete 2.0% ya ditshila kaofela tse fumanwang.
Tlhahlobo-
Mobile phase-Lokisetsa tharollo e nang le motsoako oa metsi-saturated n-butyl chloride, metsi-saturated methylene chloride, glacial acetic acid, le tetrahydrofuran (350:125:15:10).Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography <621>).
Tharollo e tloaelehileng ea ka hare-Ho sebelisa chloroform e tletseng metsi, lokisetsa tharollo ea isoflupredone acetate e nang le hoo e ka bang 0.04 mg ka mL.
Tlhophiso e tloaelehileng-Hlakola palo e lekantsoeng e nepahetseng ea USP Diflorasone Diacetate RS ka har'a tharollo e tloaelehileng ea ka hare ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 33µg ka mL.
Boitokisetso ba tlhahlobo-Fetisetsa hoo e ka bang 15 mg ea Diflorasone Diacetate, e lekantsoeng hantle, ho 500-mL volumetric flask.Kenya tharollo ea maemo a ka hare ho molumo, 'me u kopanye.
Chromatographic system (sheba Chromatography <621>)-Mokelikeli oa chromatograph o na le mochine oa 254-nm le kholomo ea 4.6-mm × 10-cm e nang le 3- µm packing L3.Sekhahla sa phallo ke hoo e ka bang 2.5 mL ka motsotso.Chromatograph Tekanyetso ea Tekanyetso, le ho tlaleha libaka tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: qeto, R, pakeng tsa litlhōrō tsa analyte le litlhōrō tsa maemo a ka hare ha li ka tlase ho 12;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang tse 'ne ha e fete 2.0%.
Ts'ebetso-Ka karohano kenya li-volume tse lekanang (tse ka bang 10 µL) tsa Tokisetso e Tloaelehileng le boitokisetso ba Assay ho chromatograph, rekota li-chromatogram, 'me u lekanye libaka tsa litlhoro tse kholo.Linako tse lekanyelitsoeng tsa ho boloka li ka ba 1.0 bakeng sa diflorasone diacetate le 2.4 bakeng sa maemo a ka hare.Bala palo, ka mg, ea C 26H32F2O7 karolong ea Diflorasone Diacetate e nkiloeng ka foromo:
0.5C(RU / RS)
moo C e leng mahloriso, ho µg ka mL, ea USP Diflorasone Diacetate RS ho tokisetso e tloaelehileng;le RU le RS ke likarolelano tsa libaka tse phahameng tsa Diflorasone Diacetate le libaka tse tloaelehileng tsa ka hare tse fumanoang ho tloha ho lokisetsa Assay le ho lokisetsa Standard, ka ho latellana.