DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity >99.0% (GC) Factory Hot Sale

Kaha Meenvin o tlalehile ho lokisoa ha DMF-DMA (N,N-Dimethylformamide Dimethyl Acetal) ka 1956, DMF-DMA e fetohile reagent e atisang ho sebelisoa ho organic synthesis.
DMF-DMA e sebelisoa haholo kahong ea mehele ea heterocyclic e nang le litho tse hlano kapa tse tšeletseng ka mokhoa oa ho koala lesale.DMF-DMA e na le maikutlo a bonolo le chai e ngata, haholo-holo bakeng sa metsoako e phahameng ea ho hanyetsa.
Sebopeho se akaretsang sa metsoako ea amide acetal ke se latelang:
E sebelisoang ka ho fetisisa ke DMF-DMA le DMF-DEA, amide acetal e bonolo ho hydrolyzed, e ka ba esterified, amidine, alkylation le cyclization reactions.
Athomo ea carbon e bohareng ea DMF-DMA e hokahane le li-heteroatom tse tharo tse nang le electronegative e kholo, e etsang hore e be le ts'ebetso e matla ea electrophilic.Tlas'a ketso ea acid, sehlopha sa alkoxy se bonolo ho tloha, 'me li-ion tse ntle tse nang le ts'ebetso e matla ea electrophilic lia fumanoa.Karabelo ea DMF-DMA haholo-holo e na le karabelo ea methylation le karabelo ea sebopeho.
"One-carbon Syntheson" ea DMF-DMA
Karabelong ea ho koaloa ha loop e kenyelletsang DMF-DMA, athomo e le 'ngoe feela ea khabone sehlahisoa hangata e fanoa ke DMF-DMA, kahoo DMF-DMA e ka nkuoa e le carbon syntheson.
DMF-DMA esterification reaction
DMF-DMA esterification e thusa mefuta e fapaneng ea li-carboxylic acid ho hlahisa C1-20 alkyl kapa aryl esters habonolo, 'me lihlahisoa li ka aroloa habonolo ke distillation.
Adipic acid le DMF-DMA li ne li esterified ka likhato tse 80 ka lihora tse peli.Amide acetal ke khetho e nepahetseng bakeng sa esterification ea li-carboxylic acid tse nang le tšitiso ea steric kapa botsitso bo fokolang.
Karabelo ea DMF-DMA amidination le tšireletso ea li-amine tsa mantlha
Amide acetals e ke ke ea itšoara feela ka li-amine tse ka sehloohong, empa hape le li-amides, carbamates, sulfonamides ho etsa li-bond tsa hydrocarbon.
Tse kang: 2, 4-dimethyl aniline le DMF-DMA ka likhato tse 80 li ka tlosa methanol ka potlako ho etsa metsoako ea dimethamidine.
DMF-DMA e ka boela ea sebelisoa e le sehlopha se ka sehloohong sa tšireletso ea amine, sehlopha sa mantlha sa tšireletso ea amine (2 NH tšireletso eohle) mohlomong batho ba bangata ba nahana ka phthalyl, pyrrole ring, double Boc, double PMB, joalo-joalo, empa tšireletso ea DMF-DMA ea mantlha. amine, maemong a mang hape ke leano la ts'ireletso le sebetsang haholo, ts'ireletso e hloka feela TFA motsoako.
Tšireletso ea Amino - Kenyelletso e 13 e tloaelehileng ea ts'ireletso, boiphihlelo ba khetho ea motheo ea ts'ireletso, mefuta e mengata ea ts'ebeliso, maemo a kenyelletso, ho arolelana kakaretso ea maemo.
DMF-DMA e sebetsana le lihlopha tse sebetsang tsa methyl le methylene ho theha bond e habeli ea carbon-carbon
Phenylmethylation ea DMF-DMA
Karabelo ea metsoako ea Heterocyclic ho DMF-DMA
Amide acetal joalo ka mofani a le mong oa khabone e ka sebelisoa ho kopanya metsoako e fapaneng e rarahaneng le lintho tsa tlhaho tsa biomimetic.With amide acetals can be synthesized: 1,2.4 triazole, 1.2, 4 triazolone, aminoheterocyclic derivatives, pyrimidine, pyrimidine, indoles, pyridine, quinoline, thiazole, oxazolone, isooxazole, 1.2, 4-triazone, pyranone, pyrazine, pyrazine and other series ea ammonia heterocyclic derivatives, ka boela synthesized oksijene, sulfur heterocyclic metsoako.
Ho ea ka mofuta oa karabelo ea lik'hemik'hale, ts'ebeliso ea amide acetal ka heterocyclic compound synthesis e ka aroloa ka likarolo tse tharo tse latelang.
(1): amide acetal le amine, amide, carbamate lipid reaction, hlahisa mefuta e fapaneng ea mehele ea heterocyclic
Amidoacetal le amine reaction to formamidine intermediate, and then intramolecular nucleophilic ring reaction to generate various heterocycles, kapa formamidine le hydrazine, hydroxylamine, l, 2, alkyl halides e le 'ngoe kapa tse peli tse nang le lihlopha tse peli tse sebetsang tsa metsoako hammoho le ketane e telele ea carbon,' me joale lesale la intramolecular. .
Synthesis ea metsoako ea heterocyclic ka karabelo ea li-amide acetals le li-amides, tse kang motsoako oa l, 2,4 monotriazole derivatives.Ntlha ea pele, acetal e kopana le amide ho theha N, N 'tritradil,' me joale mehele e nang le phenylhydrazine ho etsa l, 2,4 monotriazole derivatives.
Amide acetals e kopana le carbamic acid kapa acetate ho etsa mehele ea heterocyclic e nang le chlorine.Bohareng ba diactive bo entsoeng ke karabelo ea amide acetal e nang le aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, e sebetsanang le hydrazine kapa hydrazine e nkeloang sebaka.Ka mohlala, bakeng sa ho lokisetsa 1,2,4 triazinone-6, equation e bontšitsoe ka tlase.Haeba u e arabela ka nitro-formate u fumana 1,2,4 triazolone-5.
Mokhoa oa ho itšoara bakeng sa ho thehoa ha 1,2,4 triazolone-5
Sebopeho sa 1.2.4-triazolidin-5 ke mehato e 'meli.Ntlha ea pele, ethyl carbamate le DMF diformaldehyde acetals li theha Nn-dimethyl-n-ethoxy-formamidine e bohareng.Ea bobeli, sehlopha sa amino se phenylhydrazine se thibela carbon ho formamidine, e lahleheloang ke -N (CH3).Ebe ammonia e leng selikalikoeng sa benzene e haufi le phenylhydrazine e hlasela carbon e sehlopheng sa carbon, e etsa anion ea oxygen, ebe para e le 'ngoe ea lielektrone e holim'a oksijene e theoha, e lahleheloa ke sehlopha sa ethoxy, ebe e hlahisa 1.2, 4-triazolone-5.
(II) Ho lokisetsa metsoako ea heterocyclic ka karabelo ea amide acetal le amide
Ena ke mokhoa o tlalehiloeng ka ho fetesisa oa ho se hloeke ha motsoako lilemong tse mashome tsa morao tjena.Ketso ea amide acetal e lekana le Grignard reagent, empa boemo ba karabelo ea amide acetal bo bonolo ebile bo bonolo.
Amide acetal e na le lihlopha tse peli tse sebetsang, reactivity e phahameng, le methyl e sebetsang, methylene reaction ho theha amidine intermediates, e ka ba karabelo e eketsehileng, ho koaloa ha lesale, le Grignard reagent le methylene reaction, feela ho lelefatsa ketane ea carbon, e ke ke ea e-ba karabelo e eketsehileng.Ka mohlala, motsoako oa lihlahisoa tsa furanochroone.
(3): amide acetal le hydroxyl, sulfhydryl compound reaction ho hlahisa oxygen, sulfur heterocyclic compounds
Tlhahiso e ka holimo ea furo felisane ke mohlala o motle oa tlhahiso ea acetal ea li-enamine derivatives le sehlopha sa hydroxyl ka ho arola palo ea endolateral, e hlahisang oxy-containing heteramine:.Mohlala o mong: catechol le DMF -- DMA li theha mehele e nang le oksijene boteng ba dichloromethane.
Karabelo ea DMF -- DMA le o-mercaptoaniline li ka hlahisa selikalikoe se nang le sebabole sa heterocyclic, mokhoa oa ho arabela o tjena.
Thuto-pale ea DMF-DMA ring closure reaction and personal reaction
(1) Batcho-Leimgruber indole synthesis
Ho lokisoa ha lihlahisoa tse fapaneng tsa Vindol tse tsoang ho o-nitrotoluene.
Mokhoa oa ho arabela
Pele ho tsohle, dimethylformamide dimethylacetal, li-ion tse mpe tsa sehlopha sa methoxy li tloha ho hlahisa lipakeng tse sebetsang haholoanyane.E hlaseloa ke li-carboanions tse entsoeng ke deprotonation ea o-nitrotoluene methyl hydrogen mme e lahleheloa ke methanol ho fumana enylamine e boletsoeng ka holimo.Sehlahisoa sa mohato ona, enamine, se tšoana le alkene e nang le lisebelisoa tsa ho hula elektronike le tse fanang ka lielektrone tse khomaretsoeng mahlakoreng ka bobeli (Push-pull olefin e polar ka matla 'me hangata e le khubelu e lefifi ka lebaka la mefuta e mengata ea motsoako oa molek'hule. ea karabelo, sehlopha sa nitro se fokotsehile ho sehlopha sa amino, se lateloa ke cyclization le ho felisoa ho fumana sehlahisoa sa ho qetela.
(2) Litšoantšo tse kopantsoeng tsa lihlahisoa tsa pyridine
(3) Synthesis ea lihlahisoa tsa pyrazole