EDC·HCl CAS 25952-53-8 Coupling Reagent Purity >99.0% (T) Factory

Tlhaloso e Khutšoanyane:

1-(3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride

Mantsoe a tšoanang: EDC·HCl

CAS: 25952-53-8

Bohloeki: >99.0% (Argentmetric Titration)

Ponahalo: Phofo e tšoeu ea Crystalline

Coupling Reagent bakeng sa Peptides Synthesis

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa 1- (3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride (EDC · HCl) (CAS: 25952-53-8) e nang le boleng bo phahameng.Ruifu Chemical e fana ka letoto la li-reagents tse sireletsang le li-reagents tse kopanyang.Ruifu e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, palo e nyane le e ngata e fumanehang.Reka EDC·HCl,Please contact: alvin@ruifuchem.com

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	1-(3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride
Litlhaloso tse tšoanang	EDC·HCl;EDAC·HCl;EDCI·HCl;EDC Hydrochloride;EDAC Hydrochloride;N-(3-Dimethylaminopropyl)-N′-Ethylcarbodiimide Hydrochloride;1-Ethyl-3- (3-Dimethylaminopropyl) carbodiimide Hydrochloride;N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide Hydrochloride;Metsi a Soluble Carbodiimide
Boemo ba Setoko	In Stock, Mass Production
Nomoro ea CAS	25952-53-8
Foromo ea limolek'hule	C8H17N3·HCl
Boima ba Molek'hule	191.70 g/mol
Melting Point	110.0 ~ 115.0℃
Botenya	0.877 g/mL ho 20℃(lit.)
Refractive Index n20/D	1.461
Boloka Tlas'a Khase ea Inert	Boloka Tlas'a Khase ea Inert
E hloahloa	Hygroscopic.E Mamela Mongobo, E Mamela Mocheso
Ho qhibiliha ha Metsi	E qhibiliha ka ho Feletseng ka Metsing
Solubility	E qhibiliha ka Dimethylformamide, Joala
Mocheso oa polokelo.	Sebaka se Phodileng le se Omileng (<5℃)
COA & MSDS	E fumaneha
Sehlopha	Coupling Reagents
Brand	Ruifu Chemical

Litlhaloso:

Lintho	Maemo a Tlhahlobo	Liphetho
Ponahalo	Phofo e Tšoeu ea Crystalline	E lumellana
Melting Point	110.0 ~ 115.0℃	112.0~114.0℃
Metsi ka Karl Fischer	<0.50%	0.10%
Masalla a ho Ignition	<0.10%	0.04%
Bohloeki (Argentmetric Titration)	>99.0%	99.70%
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)	E lumellana
Infrared Spectrum	E Ikamahanya le Sebopeho	E lumellana
Sollubility ho H2O (100 mg/mL)	Ha e na 'Mala ho ea ho Ha E Fate Haholo Bosehla, Bo hlakile	Feta
Qetello	Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng

Sephutheloana/Bobolokelo/Ho tsamaisa ka sekepe:

Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:E Mamela Mongobo.Boloka ka lijaneng tse tiisitsoeng sebakeng sa polokelo se pholileng le se omileng (<5℃) hole le lintho tse sa lumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Fana ka lefatše ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.

Mokhoa oa Teko:

Thepa: Sehlahisoa sena ke phofo e tšoeu ea kristale.
2. Boikemisetso ba litaba:
2.1 Lisebelisoa le li-reagents: potentiometric titrator, nitric acid solution (12.5 wt%), AgNO3 standard solution (0.1mol/L)
2.2 Mohlala oa ho lokisa le ho sebetsa:
200 ho 220mg e ile ea qhibiliha ka 40ml ea metsi a qhibilihisitsoeng, 'me ka mor'a hore 5ml ea tharollo ea nitric acid e eketsoe, tharollo e ile ea qhibiliha ka mokhoa o tloaelehileng ka silevera ea nitrate.
Mokelikeli o ne o titrated ho ea qetellong.Foromo ea ho bala litaba tsa sehlahisoa ke e latelang:
X = (VAgNO3*19.171)/W,
X- Peresente ea EDC.HCl, 100%.
V-Bophahamo bo jeoang ke tharollo e tloaelehileng ea AgNO3, ml
19.171-1ml AgNO3 tharollo e tloaelehileng (0.1mol / L) e jang EDC.HCl boima, mg;
W - boima ba mohlala, mg;
Mokhoa ona o ne o etsoa ka makhetlo a mararo ka tsela e tšoanang 'me ka karolelano ho nkiloe,' me phoso ha ea lokela ho feta 0.3%.Litaba tsa sehlahisoa li lokela ho ba> 99.0%.
3. Ntho e qhibilihisang: ho ea ka mokhoa oa ho etsa qeto ea ho qhibiliha (Sehlomathiso sa VII C sa khatiso ea Chinese Pharmacopoeia 2010), ntlha ea ho qhibiliha ea sehlahisoa sena e lokela ho ba 110.0 ~ 115.0 ℃.
4. Boikemisetso ba metsi: ho latela mokhoa oa ho lekanya mongobo (mokhoa oa KF) ho fumana hore na metsi a sehlahisoa sena a lokela ho ba <0.50%.
5. Polokelo: Boloka sebakeng se lefifi le se phodileng se omileng (<5℃).
6. Nako ea ho hlahloba: selemo se le seng

Mokhoa oa maiketsetso:

Melemo:

Bokhoni bo lekaneng: Lisebelisoa le litsebi tse lekaneng

Tšebeletso ea profeshenale: Tšebeletso e le 'ngoe ea ho reka

Sephutheloana sa OEM: Sephutheloana sa tloaelo le leibole lia fumaneha

Tlhahiso e potlakileng: Haeba e le ka har'a setoko, ho netefalitsoe hore ho tsamaisoa matsatsi a mararo

Thepa e tsitsitseng: Boloka thepa e lekaneng

Tšehetso ea Theknoloji: Tharollo ea theknoloji e teng

Tšebeletso e Tloaelehileng ea ho Kopanya: Ho tloha ho ligrama ho isa ho lik'hilograma

Boleng bo Phahameng: Ho thehile tsamaiso e felletseng ea netefatso ea boleng

LBH:

Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.

Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.

Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.

BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.

Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.

Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.

MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.

Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.

Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.

Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.

Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.

Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.

25952-53-8 - Kotsi le Tšireletseho:

Likhoutu tsa Kotsi
R34 - E baka ho cha
R36/37/38 - Ho hlohlona mahlong, tsamaiso ya moya le letlalo.
R41 - Kotsi ya tshenyo e kgolo mahlong
R37/38 - Ho halefisa tsamaiso ea ho hema le letlalo.
R20/21/22 - E kotsi ka ho hema, ho kopana le letlalo le haeba e koetsoe.
Tlhaloso ea Tšireletseho
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36/37/39 - Apara liaparo tse loketseng tse sireletsang, liatlana le tšireletso ea mahlo / sefahleho.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S37/39 - Apara liatlana tse loketseng le tšireletso ea mahlo / sefahleho
S36 - Apara liaparo tse loketseng tsa tšireletso.
Li-ID tsa UN UN 2735 8/PG 3
WGK Jeremane 3
RTECS FF2200000
FLUKA BRAND F CODES 1-3-10
TSCA Y
HS Code 2925290090
Hazard Note Irritant
Toxicity LD50 intravenous in mouse: 56mg/kg

Kopo:

1-(3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride (EDC·HCl) (CAS: 25952-53-8) ke phofo e tšoeu ea kristale, e bonolo habonolo, e qhibiliha ka metsing, e qhibilihang ka ethanol, e sebelisoang e le activating reagent bakeng sa carboxyl. lihlopha tsa amide synthesis, tse sebelisetsoang ho kenya tšebetsong lihlopha tsa phosphate, ho kopanya liprotheine le li-nucleic acid, le tlhahiso ea li-immunocouplers.EDC-HCl e sebelisoa ka mefuta ea pH ea 4.0-6.0 'me e atisa ho sebelisoa hammoho le N-Hydroxysuccinimide (NHS) kapa N-Hydroxysulfosuccinimide letsoai la sodium ho ntlafatsa katleho ea ho kopanya.
EDC·HCl ke carbodiimide e qhibilihang ka metsing, e sebelisoang haholo ho kopanya peptide.EDC·HCl e sebelisoa joalo ka ntho e kenyang tšebetsong carboxyl.E bapala karolo ea bohlokoa bakeng sa ho thibela li-biomolecule tse kholo ho kopana le N-hydroxysuccinimide.E boetse e sebelisoa ho acylation ea phosphoranes.
Motsoako o qhibilihang ka metsi oa carbodiimide o thusa ho kopanya haptens ho liprotheine le polypeptides.E sebelisoa ho fetola li-receptor tsa NMDA hape e le moemeli oa condensing ho peptide synthesis.Monyetla o moholo oa ho kopanya EDAC ke ho tlosoa habonolo ha reagent e feteletseng le urea e lumellanang ka ho hlatsoa ka acid e hlapollang kapa metsi.Li-Carbodiimides li etsa hore ho be le li-amide bond, carboxylic acid, le amine ka ho kenya tšebetsong carboxylate ho etsa O-acylurea.Sebaka sena sa bohareng se ka hlaseloa ke amine ka ho toba ho etsa amide.EDAC e lokolloa e le ntho e tsoang ho urea e qhibilihang.
EDC · HCl e ka sebelisoa bakeng sa ho kopanya li-amides.E sebelisoa e le moemeli oa ho kopanya ha ho etsoa li-ester ho tloha ho carboxylic acids ho sebelisa dimethylaminopyridine e le sesosa.
Haholo-holo ho na le lisebelisoa tse tharo tse sebelisoang hangata: DCC, DIC le EDC·HCl.Tšebeliso ea mofuta ona oa condensing agent ka kakaretso e hloka ho eketsoa ha li-acylation catalysts kapa activators, tse kang DMAP, HOBt, joalo-joalo Ho tloha ha ho kenyelletsoa bohareng ba acid ho carbodiimide mohatong oa pele oa karabelo e sa tsitsa, haeba acylation. catalyst ha e sebelisoe ho e fetolela ho ester e sebetsang e sebetsang kapa amide e sebetsang, e tla hlophisoa bocha hore e be sehlahisoa se ts'oanang se tsitsitseng sa urea (Path B).Condensation activator: Ho na le mefuta e latelang ea condensation activator e sebelisoang hangata.Hona joale, 4-N, N-dimethylpyridine (DMAP) e 'nile ea sebelisoa haholo ho susumetsa karabelo e fapaneng ea acylation.Ka linako tse ling 4-PPY e ka sebelisoa ha phello ea catalytic ea DMAP e se ntle.Ho latela lingoliloeng tse amehang, bokhoni ba eona ba matla bo phahame ka makhetlo a sekete ho feta DMAP.har'a li-condenser tse tharo tse sebelisoang ka tloaelo, DCC le DIC li theko e tlaase.Ka kakaretso DCC le DMAP li sebelisoa hammoho.E 'ngoe ea mathata a maholo ka ho fetisisa a ho sebelisa DCC ke hore sehlahisoa se seng sa karabelo, dicyclohexylurea, se na le solubility e nyenyane karolong e akaretsang ea lintho tse phelang empa e qhibiliha hanyenyane, kahoo ho thata ho e tlosa ka ho feletseng ka mekhoa e meng e tloaelehileng ea ho hloekisa, recrystallization, kholomo ea chromatography, joalo-joalo;hobane ho qhibiliha ha dicyclohexylurea ho ether e batla e le nyenyane ho feta metsoako e meng, ka hona, phekolo ea mofuta ona oa karabelo ka kakaretso e etsa hore motsoako oa karabelo e be mouoane ebe o eketsa ether, 'me o hloekisa boholo ba dicyclohexylurea pele ho phekolo e eketsehileng.Hobane diisopropylurea e hlahisoang ke DIC e na le ho qhibiliha ho betere ho lihlapolli tsa manyolo ka kakaretso, hangata e sebelisoa ho kopantseng k'hemistri e tiileng-phase synthesis.Hona joale EDC e sebelisoa haholo k'hemistri ea meriana.E 'ngoe ea litšobotsi tsa eona tse ka sehloohong ke hore urea e hlahisoang ka mor'a karabelo e qhibiliha ka metsing 'me e bonolo ho e hlatsoa.Ka kakaretso, EDCI e kopantsoe le HOBt (hlokomela: karabelo ena HOBt hangata ke ea bohlokoa, ho seng joalo e ka lebisa ho chai e tlase haholo ea condensation).Ka linako tse ling haeba tšitiso ea boemo ba asiti e le kholo kapa ho na le sehlopha sa ho ntša elektronike, karabelo e tla lula e le mohato o sebetsang oa ester (ester e sebetsang e na le letšoao le matla la mabala a maholo 'me e ka fumanoa ke MS kapa LC-MS).