Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Entecavir Monohydrate

CAS: 209216-23-9

Ponahalo: Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu

Setlhare sa antiviral se sebelisetsoang ho phekola lefu la Hepatitis B

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

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Tlhaloso:

Phepelo ea Moetsi e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Entecavir Monohydrate
CAS: 209216-23-9
E sebelisoa ho phekola lefu la Hepatitis B
API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Entecavir Monohydrate
Litlhaloso tse tšoanang	Entecavir Hydrate;9 - [(1S,3R,4S) -4-Hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]guanine Monohydrate
Nomoro ea CAS	209216-23-9
Nomoro ea KAtse	RF-API79
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C12H17N5O4
Boima ba Molek'hule	295.3
Melting Point	>220℃
Botenya	1.81
Boemo ba ho Romela	E Rometsoe ka Tlas'a Mocheso oa Mocheso
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu
Solubility	E qhibiliha ka bolokolohi ho Dimethylformamide, e Hanyenyane Hanyenyane ka Metsing, Ethanol le Methanol
Boitsebiso ba IR	Spectrum ea sampole e lumellana le ea referense standard
Boitsebiso ba HPLC	Nako ea ho boloka sampole ea teko e tsamaisana le ea maemo a referense
Litaba tsa Metsi (ka KF)	5.5%~6.5%
Specific Optical Rotation	+24.0° ho ea ho +30.0° (DMF: MeOH=1:1 C=1%) (ho ntho e anhydrous)
Masalla a ho Ignition	≤0.10%
Lintho Tse Amanang
Furoentecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Motsoako o amanang le Entecavir A	≤0.10%
Tšilafalo efe kapa efe e sa Boleloeng	≤0.10%
Litšila ka Kakaretso	≤0.30%
Metsoako e setseng
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl Chloride	≤1000ppm
Joala ba Benzyl	≤1000ppm
Moeli oa Likokoana-hloko
Kakaretso ea Lipalo tsa Aerobic	≤100cfu/g
Litomoso le hlobo	≤10cfu/g
Escherichia Coli	Ha ea Lokela ho Fumaneha
Litšepe tse boima	≤10ppm
Tlhahlobo	98.0%~102.0% (HPLC; motheong oa anhydrous)
Boholo ba Karolo	95% ea likaroloana e lokela ho ba ka hare ho 125um
Tekanyetso ea Teko	Maemo a Khoebo;United States Pharmacopoeia (USP) Standard
Tšebeliso	Setlhare sa antiviral se sebelisetsoang ho phekola lefu la Hepatitis B

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Entecavir Monohydrate (CAS 209216-23-9) ke moriana o thibelang likokoana-hloko o sebelisoang ho phekola tšoaetso ea kokoana-hloko ea Hepatitis B (HBV).Entecavir Monohydrate ke analog ea nucleoside (haholo-holo, analogue ea guanine) e thibelang reverse transcript, DNA replication le transcript ho vira.Ke mofuta o mocha oa lithethefatsi tsa kokoana-hloko ea cyclopentyl acyl guanosine e khahlanong le Hepatitis B e nang le liphello tsa eona tsa meriana tse tšoanang le Entecavir.E sebelisoa ka tleliniki ho phekola batho ba baholo ba sa foleng Hepatitis B moo ho nang le ho ikatisa ha kokoana-hloko e sebetsang, ho eketseha ha serum transaminase ALT kapa liso tse sebetsang tse bontšitsoeng ho tloha histology ea sebete.Entecavir Monohydrate ke inhibitor e matla le e khethollang ea HBV, e nang le EC50 ea 3.75 nM ka seleng ea HepG2.Entecavir ke reverse transcriptase inhibitor.E thibela kokoana-hloko ea Hepatitis B (HBV) ho ikatisa le ho fokotsa bongata ba kokoana-hloko 'meleng.