Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Purity >99.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) e nang le boleng bo phahameng.Ruifu Chemical e fana ka letoto la li-amino acid.Re ka fana ka litšebeletso tsa lefats'e ka bophara, theko ea tlhōlisano, palo e nyenyane le e ngata e fumanehang.Reka Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | N-Fmoc-L-Leucine |
| Litlhaloso tse tšoanang | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Leucine;N-(9-Fluorenylmethoxycarbonyl) -L-Leucine |
| Boemo ba Setoko | Ka Setoko, Bokhoni ba Tlhahiso ho Lithane ka Khoeli |
| Nomoro ea CAS | 35661-60-0 |
| Foromo ea limolek'hule | C21H23NO4 |
| Boima ba Molek'hule | 353.42 g/mol |
| Melting Point | 153.0 ho isa ho 160.0 ℃ |
| Botenya | 1.207±0.06 g/cm3 |
| E hloahloa | Hygroscopic |
| Solubility ka Methanol | Hoo e ka bang Ponaletso |
| Mocheso oa polokelo. | Sebaka se pholileng le se omileng (2~8℃) |
| COA & MSDS | E fumaneha |
| Sehlopha | Fmoc-Amino Acids |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo e Tshweu | Phofo e Tshweu |
| Potoloho e Khethehileng [α]20/D | -25.0°±2.0° (C=1 ho DMF) | -24.6° |
| Melting Point | 153.0 ho isa ho 160.0 ℃ | 155.1 ℃ |
| TLC | ≥98.0% | >98.0% |
| Bohloeki ba Optical | <0.30% D-Enantiomer | E lumellana |
| Ho Hlakola ha Tharollo | 0.3 gram ho 2ml DMF Hlakile Tharollo | E lumellana |
| Teko ea Kaiser | <0.05% | <0.05% |
| Metsi ka Karl Fischer | <0.50% | 0.12% |
| Tahlehelo ka ho Omisa | <0.50% (60℃, 2h) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | E lumellana |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | E lumellana |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | E lumellana |
| Fmoc-Ile-OH | <0.10% (HPLC) | E lumellana |
| Assay Free Amino Acid | <0.20% (GC) | E lumellana |
| Ethyl Acetate | <0.50% (GC) | E lumellana |
| Mokhoa oa Bohloeki / Analysis | >99.0% (HPLC) | 99.85% |
| Bongata ba Spectrum | Tumellanong le Maemo | E lumellana |
| Sekhahla sa NMR | Tumellanong le Maemo | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso | |
Sephutheloana: Botlolo ea Fluorinated, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse tiisitsoeng sebakeng sa polokelo se pholileng le se omileng (2~8℃) hole le lintho tse sa lumellaneng.Sireletsa leseli le mongobo.
Mokhoa oa ho hlahloba
1. Ponahalo
-- Tlhahlobo ea pono
2. Purity (HPLC)
2.1 Seletsa
chromatography ea mokelikeli e phahameng ea ts'ebetso, mochini oa PDA.
Elektronike analytical balance
2.2 Reagent
Acetonitrile (mophato oa chromatographic), Trifluoroacetic acid (mophato oa chromatographic)
2.3 Maemo a Chromatographic
2.3.1 Kholomo: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Bophahamo ba maqhubu a ho lemoha: INC220nm
Sekhahla sa phallo: 1.0mL/min
Saese ea mohlala: 10μL (referense)
Monyetla: acetonitrile
Nako ea ho bokella lintlha: 25.00min
2.4 Ho lokisetsa mohato oa Mobile
Mobile phase A (0.1% trifluoroacetic acid metsi): ka nepo monya 2.0ml trifluoroacetic acid, e hlapolotsoe ka metsi ho 2000ml, kopanya hantle, le degassing;
Mobile phase B (0.1% acetonitrile trifluoroacetic acid): ka nepo monya 2.0ml trifluoroacetic acid, e hlapollotsoe ho 2000ml ka acetonitrile, ho kopanya le ho senya;
Nako (mets) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Tokiso ea tharollo ea mohlala
Beha le ho qhala sampole ea 0.1g ka acetonitrile 'me u hlapolle ho 100ml, sisinya hantle bakeng sa tšebeliso, kapa mahloriso a tšoanang.Lokisetsa disampole tse pedi ka ho bapana.
2.7 Boikemisetso ba Mohlala
Hlakola mohlala ho latela mokhoa o latelang oa lisampole:
Ho feta ente e le 'ngoe ea tharollo e se nang letho
1 ea mohlala oa nale tharollo 1#
1 tharollo ea nale 2#
2.8 Sephetho Palo
2.8.1 Mokhoa oa ho tloaeleha ha sebaka sa tlhoro o ile oa sebelisoa ho bala bohloeki ba HPLC ka ho tlosa sebaka se se nang letho.
2.8.2 Phapang e lekanyelitsoeng ea bohloeki ba linale tse peli ha ea lokela ho feta 1%
2.8.3 Haeba liphello tsa liente ka bobeli li finyella litekanyetso tsa ho amoheloa, bohloeki bo tloaelehileng bo nkoa e le sephetho sa ho qetela.
3, Ntho e qhibilihang -- RY-1 sesebelisoa sa ntlha ea ho qhibiliha
4. Tahlehelo ka mokhoa oa ho omisa teko
4.1 Lisebelisoa:
Ovine ea ho omisa ea thermostatic ea motlakase, tekanyo ea 1/10,000.
4.2 Mokhoa:
Ka botlolong ea boima bo bataletseng e nang le boima bo sa khaotseng le sekoahelo sa molomo oa fatše o ommeng ho feta tekano, bekha gram e le 1 (e nepahetseng ho isa ho 0.0001 gram) ea sampole.Sampole e lokela ho aloa ka mokhoa o ts'oanang ka tlase ho botlolo e lekanyang ka botenya bo sa feteng 10mm, e kenngoe ka ontong ea ho omisa ea thermostatic, e omelle ka 105 ~ 110 ℃ ka lihora tse 3, ebe o kena ka phapusing ea ho omisa ho pholile. mocheso oa kamore bakeng sa ho bekha.
Palo: Tahlehelo ha ho omisoa %= (M1-M2) ÷M×100
Moo: M1: boima ba sampole le botlolo ea ho metha pele e omisoa, ligrama
M2: boima ba sampuli le botlolo ea ho lekanya ka mor'a ho omisa, ka ligrama
M: Boima ba mohlala, ligrama
5. Ho potoloha ho khethehileng
- Potoloho e khethehileng e lekantsoe ho latela GB/T613-1988
Tokiso ea mohlala: 0.5000g sampole e lekantsoe ka nepo mme e isoa botlolong e hloekileng le e omileng ea 50ml ea volumetric, 20ml DMF e ile ea eketsoa, botlolo e ile ea koaheloa 'me ea sisinyeha hore e qhibilihe, ebe e hlapolotsoe sekala ka DMF.
Teko: Fetola zero ea gyroscope pele ho tlhahlobo, ebe u kenya tube ea teko ka tharollo ea sampole, rekota Angle ea ho potoloha, 'me u bale ho potoloha ho itseng ha sampole ka foromo e latelang.
[а]D20=(r×50) ÷ (L×W)
[а]D20: Potoloho e khethehileng ea optical ho 25 ℃ ea tharollo ea sampole
r: Potoloho e bonoang ho 20 ℃ bakeng sa tharollo ea sampole
50: Bolumo ea tharollo ea sampole e lokisitsoeng (ml)
w: Boima ba mohlala (g)
L: Bolelele ba tube ea optical (dm)
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
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Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Matshwao a Kotsi Xi - E tenang
Likhoutu tsa Kotsi 36/37/38 - Ho hlohlona mahlong, tsamaiso ea ho hema le letlalo.
Tlhaloso ea Tšireletseho S22 - U se ke ua hema lerōle.
S24/25 - Qoba ho kopana le letlalo le mahlo.
S36/37/39 - Apara liaparo tse loketseng tse sireletsang, liatlana le tšireletso ea mahlo / sefahleho.
S27 - Tlosa hanghang liaparo tsohle tse silafetseng.
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
WGK Jeremane 3
HS Code 2922491990
N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) ke motsoako oa amino acid o ka lokisoang ke karabelo ea L-Leucine le 9-Fluorenomethoxycarbonyl Chloride.
Fmoc-amino acids, e sebelisoang ka har'a peptide synthesis, e sebelisoang e le motsoako oa organic synthesis bohareng, bohareng ba meriana, reagent ea biochemical kapa reagent ea lik'hemik'hale.
Fmoc-L-Leu-OH, ke motsoako oa amino acid, o sebelisoang k'hemistri ea peptide.Sebaka se tloaelehileng sa moaho bakeng sa motsoako o tiileng oa mohato oa peptide ho latela maqheka a Fmoc.Hape ke e 'ngoe ea li-ligand tse ncha tsa PPARγ tse ka kenyang PPARγ ka litsela tse fapaneng, tse fokotsang phapang ea li-osteoclasts, kahoo ke lipheo tse molemo tsa phekolo ea lefu la tsoekere ho feta lithethefatsi tsa setso tsa antidiabetic.
Tokisetso ea 1.05g (0.008 mol) L-Leucine solid e qhibilihisoa ka 10% sodium carbonate solution, e hlohlelletsoa ho qhala ka ho feletseng glycine solid, le 9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) e qhibilihisitsoeng ka toluene (2~205 ml) E eketsoa ka 20 ~ 30 ℃, theola tlatsetso bakeng sa metsotso e 30 ~ 60, emisa tlatsetso, hlohlelletsa ho 20 ~ 30 ℃ bakeng sa lihora tse 1 ~ 8, eketsa 30-200 ml ea metsi ho hlapolla, 'me u ntše ka n-butyl. acetate (80 ml) ho tlosa 9-fluorene methoxycarbonyl chloride e feteletseng, Mokhahlelo oa metsi o fumanoeng o na le acidity ea concentrated hydrochloric acid ho PH = 0.5 ~ 3.5, ebe e ntšoa ka n-butyl acetate (80 ml), 'me karolo ea oli e fumanoeng ke e hlatsoitsoe ka metsi ho tlosa hydrochloric acid, karolo ea oli e ne e tsepamisitsoe ho tlosa n-butyl acetate solvent, likristale tse tšoeu li ile tsa fokotseha, tsa hloekisoa le ho omisoa ho fumana 2.46g ea Nα-9-fluorene methoxycarbonyl-L-leucine, ka lihlahisoa tsa 87.0 %.
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