Fmoc-Ser(tBu)-OH CAS 71989-33-8 Fmoc-O-tert-Butyl-L-Serine Purity >98.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Fmoc-O-tert-Butyl-L-Serine (Fmoc-Ser(tBu)-OH) (CAS: 71989-33-8) e nang le boleng bo phahameng.Ruifu Chemical e fana ka letoto la li-amino acid.Re ka fana ka litšebeletso tsa lefats'e ka bophara, theko ea tlhōlisano, palo e nyenyane le e ngata e fumanehang.Reka Fmoc-Ser(tBu)-OH,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Fmoc-O-tert-Butyl-L-Serine |
| Litlhaloso tse tšoanang | Fmoc-Ser(tBu)-OH;Fmoc-L-Ser(tBu)-OH;N-Fmoc-O-tert-Butyl-L-Serine;O-tert-Butyl-N-Fmoc-L-Serine;O-tert-Butyl-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Serine;N-(9-Fluorenylmethoxycarbonyl)-O-tert-Butyl-L-Serine |
| Boemo ba Setoko | Ka Setoko, Bokhoni ba Tlhahiso ho Lithane ka Khoeli |
| Nomoro ea CAS | 71989-33-8 |
| Foromo ea limolek'hule | C22H25NO5 |
| Boima ba Molek'hule | 383.44 g/mol |
| Melting Point | 125.0 ~ 140.0℃ |
| Botenya | 1.216 |
| Mocheso oa polokelo. | Sebaka se pholileng le se omileng (2~8℃) |
| COA & MSDS | E fumaneha |
| Sehlopha | Fmoc-Amino Acids |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo e Tshweu | Phofo e Tshweu |
| Potoloho e Khethehileng [α]20/D | +25.0°±2.5° (C=1 ho EtOAc) | +24,8° |
| Melting Point | 125.0 ~ 140.0℃ | 130.6 ~ 131.1℃ |
| Metsi ka Karl Fischer | <1.00% | 0.194% |
| Tahlehelo ka ho Omisa | <1.00% | 0.32% |
| Masalla a ho Ignition | <0.10% | <0.10% |
| Bohloeki ba Optical | <0.30% D-Enantiomer | 0.0782% |
| Ho Hlakola ha Tharollo | 0.3 gram ho 2ml DMF Hlakile Tharollo | E lumellana |
| Mokhoa oa Bohloeki / Analysis | >98.5% (HPLC) | 99.15% |
| 300 MHz 1H | E Ikamahanya le Sebopeho | E lumellana |
| Elemental Analysis | E tsitsitseng | E tsitsitseng |
| Tlhahlobo ea TLC | Letheba le le leng | E lumellana |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana: Botlolo ea Fluorinated, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse tiisitsoeng sebakeng sa polokelo se pholileng le se omileng (2~8℃) hole le lintho tse sa lumellaneng.Sireletsa leseli le mongobo.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Mekhoa ea ho hlahloba
1. Ponahalo
-- Tlhahlobo ea pono
2. Purity (HPLC)
2.1 Seletsa
chromatography ea mokelikeli e phahameng ea ts'ebetso, mochini oa PDA.
Elektronike analytical balance
2.2 Reagent
Acetonitrile (mophato oa chromatographic), trifluoroacetic acid (mophato oa chromatographic)
2.3 Maemo a Chromatographic
2.3.1 Kholomo: YMC-ODS-AM, 5 μl, 250x4.6 mm
2.3.2 Bophahamo ba maqhubu a ho lemoha: INC220nm
Sekhahla sa phallo: 1.0mL/min
Saese ea mohlala: 10 μl (tšupiso)
Monyetla: acetonitrile
Nako ea ho bokella lintlha: 25.00min
2.4 Ho lokisetsa mohato oa Mobile
Mobile phase A (0.1% trifluoroacetic acid metsi): ho monya ka ho nepahetseng 2. Hlakola Oml trifluoroacetic acid ka metsi ho 2000m1, kopanya hantle, le degassing;
Mobile phase B (0.1% acetonitrile trifluoroacetic acid): ho monya ho nepahetseng 2.0ml trifluoroacetic acid e ile ea hlapolloa ho 2000m1 ka acetonitrile, e tsoakiloeng le ho senya;
2.5 Lenaneo la Gradient la mohato oa mohala
Nako (mets) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Tokiso ea tharollo ea mohlala
Beha le ho qhala sampole ea 0.1g ka acetonitrile 'me u hlapolle ho 100ml, sisinya hantle bakeng sa tšebeliso, kapa mahloriso a tšoanang.Lokisetsa disampole tse pedi ka ho bapana.
2.7 Boikemisetso ba Mohlala
Hlakola mohlala ho latela mokhoa o latelang oa lisampole:
Ho feta ente e le 'ngoe ea tharollo e se nang letho
1 Stitch sampole tharollo 1#
Mohlala o le mong oa tharollo ea 2#
2.8 Palo ea sephetho
2.8.1 Mokhoa oa ho tloaeleha ha sebaka sa tlhoro o ile oa sebelisoa ho bala bohloeki ba HPLC ka ho tlosa sebaka se se nang letho.
2.8.2 Phapang e lekanyelitsoeng ea bohloeki ba linale tse peli ha ea lokela ho feta 1%
2.8.3 Haeba liphello tsa liente ka bobeli li finyella litekanyetso tsa ho amoheloa, bohloeki bo tloaelehileng bo nkoa e le sephetho sa ho qetela.
3, Ntho e qhibilihang -- RY-1 sesebelisoa sa ntlha ea ho qhibiliha
4. Tahlehelo ho omisa mokhoa oa ho lemoha
4.1 Lisebelisoa:
Ovine ea ho omisa ea thermostatic ea motlakase, tekanyo e le 'ngoe ho tse likete tse leshome.
4.2 Mokhoa:
Ka botlolo ea boima bo bataletseng e nang le sekoahelo sa fatše se nang le boima bo sa khaotseng le ho omisa ho feta tekano, lekanya gram e le 'ngoe ea sampuli (e nepahetseng ho 0,0001 gram).Mohlala o lokela ho aloa ka mokhoa o ts'oanang ka tlase ho botlolo ea boima ka botenya bo sa feteng 10mm, o kenngoe ka ontong ea ho omisa ka mocheso o sa feleng, o omelle ho 105-110 ℃ lihora tse 3, ebe o kena ka phapusing ea ho omisa, o pholile. mocheso oa kamore le ho bekha.
Palo: Ho lahleheloa ke boima ba 'mele %= (M1-M2) ÷M×100
Moo: M1: boima ba sampole le botlolo ea boima pele e omisoa, g
M2: Boima ba sampole le botlolo ea boima ka mor'a ho omisa, g
M: Boima ba mohlala, gram
5. Ho potoloha ho khethehileng
- Potoloho e khethehileng e lekantsoe ho latela GB/T613-1988
Tokisetso ea mohlala: 0.5000g ea sampuli e ne e lekantsoe ka nepo 'me ea fetisetsoa botlolong e hloekileng le e omileng ea 50ml ea volumetric e nang le 20ml Ethyl acetate.Botlolo e ile ea koaheloa 'me ea sisinyeha ho qhaqha Ethyl acetate.
Teko: Fetola zero ea gyroscope pele ho tlhahlobo, ebe u tlatsa tšupu ea teko ka tharollo ea sampole, ngola Angle ea ho kheloha ea ho potoloha, 'me u bale ho potoloha ho itseng ha sampole u sebelisa foromo e latelang.
[α]20/D= (r×50) ÷(L×W)
Moo:
[α]20/D: Potoloho e khethehileng ea tharollo ea sampole ho 25℃
r: Ho potoloha ho bonoa ho 25 ℃ bakeng sa tharollo ea sampole
50: Lokisetsa boholo ba tharollo ea sampole (ml)
w: Boima ba mohlala (g)
L: Bolelele ba tube ea Optical (dm)
6. Tlhahlobo ea TCL
Tokisetso ea mohlala: 0.5000g sampole e lekantsoe ka nepo 'me ea isoa botlolong e hloekileng le e omeletseng ea 50ml ea volumetric, 40ml EtoH e ile ea eketsoa, botlolo e ile ea koaheloa 'me ea sisinyeha hore e qhibilihe, ebe e hlapolotsoe sekaleng ka EtoH.
Tokisetso ea sampole ea taolo: sampole ea 0.5000g e lekantsoe hantle mme e isoa botlolong e hloekileng le e omeletseng ea 50ml, metsi a 40ml le marotholi a 2 a 6N hydrochloric acid a kentsoe, botlolo e ile ea koaheloa mme ea sisinyeha hore e qhibilihe, ebe e hlapolotsoe sekala ka metsi.Ebe u nka 0.5 ea mokelikeli o ka holimo 'me u e hlapolle ka ethanol ka botlolo ea bophahamo ba 100ml ho sampole ea referense e nang le 1.0% ea masala a amino acid.
Lisampole tse 10 tsa microliter li nkiloe ka sering ea microsampling, 'me lisampole li behiloe holim'a poleiti ea silicone ea GF254.5 microliter, 10 microliter le 15 microliter point plates li ile tsa nkoa bakeng sa lintlha tsa ho bapisa, ka ho latellana.
Moemeli oa nts'etsopele: n-butanol: glacial acetic acid: metsi =4:1:1.
Moemeli o hlahisang mebala: 5% tharollo ea ninhydrin methanol.
Ts'ebetso ea nts'etsopele ea mebala: pele, sebelisa se omisang moriri ho omisa poleiti ea gel ea silika, ebe o e kenya ka har'a tharollo ea 5% ninhydrin methanol, ebe o omisa, ebe o chesa ka mocheso o phahameng ka sebōping sa motlakase bakeng sa nts'etsopele ea mebala.
Kahlolo: Sheba nako ea 'mala oa sehlahisoa, boholo ba matheba, mahloriso a mebala le papiso le sehlahisoa sa taolo, ahlole hore se maemong ao.
Matshwao a Kotsi Xi - E tenang
Likhoutu tsa Kotsi 36/37/38 - Ho hlohlona mahlong, tsamaiso ea ho hema le letlalo.
Tlhaloso ea Tšireletseho S24/25 - Qoba ho kopana le letlalo le mahlo.
S36/37/39 - Apara liaparo tse loketseng tse sireletsang, liatlana le tšireletso ea mahlo / sefahleho.
S27 - Tlosa hanghang liaparo tsohle tse silafetseng.
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
WGK Jeremane 3
HS Code 2922491990
Fmoc-O-tert-Butyl-L-Serine (Fmoc-Ser(tBu)-OH) (CAS: 71989-33-8) ke motsoako oa serine.
Fmoc-amino acid, e sebelisoang e le amino acid e sireletsang monoma, e sebelisoang ho peptide synthesis, Fmoc solid-phase peptide synthesis, e sebelisoang e le motsoako oa organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent kapa chemical reagent.
Fmoc-Ser(tBu)-OH ke sesebelisoa se sirelelitsoeng sa N-terminal se sebelisoang ho peptide synthesis.E meng ea mehlala e tlalehiloeng ke: Total synthesis of an antibiotic, daptomycin, by cyclization via chemoselective serine ligation.Tokisetso ea MUC1, peptide ea mothusi oa T-cell, e sebelisang li-condensation tsa sekhechana sa pentafluorophenyl ester-mediated.Linear solid-phase peptide synthesis ea ubiquitin le diubiquitin.
Mokhoa oa tlhahiso ea O-tert-Butyl-L-Serine e emisitsoe ka tharollo ea dioxane, sehlahisoa se tala se fumanoa ka acylation reaction ka fluorenylmethoxycarbonyl azide, e ntšoang ka ethyl acetate pH 9-10 mme e hloekisoa ka recrystallization.
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