Fondaparinux Sodium CAS 114870-03-0 API

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Fondaparinux Sodium

CAS: 114870-03-0

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Tekanyetso: 95.0%~103.0% (ka Motheo o Omisitsoeng)

Antithrombotic Anticoagulant, Factor Xa Inhibitor

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Lihlahisoa tse Amanang

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Tlhaloso:

Fana ka Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Fondaparinux Sodium
CAS: 114870-03-0
Antithrombotic Anticoagulant, Factor Xa Inhibitor
API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Fondaparinux sodium
Nomoro ea CAS	114870-03-0
Nomoro ea KAtse	RF-API84
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C31H43N3O49S8.10Na
Boima ba Molek'hule	1728.08
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e tšoeu
Mokhoa oa ho hlahloba / oa ho hlahloba	95.0% ~ 103.0% (ka motheo o omisitsoeng)
Solubility	E qhibiliha ka Bolokolohi ka Metsing, 2.0M Sodium Chloride le 0.5M Sodium Hydroxide le Insoluble ka Ethanol
Boitsebiso ba 13C-NMR	Resonances bakeng sa Fondaparinux Sodium e lokela ho hlokomeloa ho 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7, pp.Liphetoho tsa lik'hemik'hale tsa matšoao ana ha li fapane ho feta ± 0.3ppm lipontšo tse ling tsa bophahamo bo fapaneng le liphetoho tsa lik'hemik'hale, tse hlahisoang ke Fondaparinux Sodium, mohlomong e bonoa pakeng tsa 58.0 ~ 80.5 ppm le 98.7 ~ 104.5ppm.
Boitsebiso ba HPLC	Nako ea ho boloka tlhōrō e kholo ea tharollo ea mohlala e lumellana le ea tharollo e tloaelehileng
Boitsebiso ba AAS	Sodium e lokela ho ba le mokhoa oa ho monya ho 330.2nm tlas'a qeto ea sodium
pH	6.0~8.0
Sodium (Na)	11.5% ~ 15.0% (E balloa ka anhydrous le solvents mahala)
Sulfate ea mahala	≤0.30%
Chloride e setseng	≤1.00%
Lintho Tse Amanang
Tšilafalo A	≤0.80%
Tšilafalo B	≤0.60%
Tšilafalo e 'Ngoe	≤0.30%
Litšila ka Kakaretso	≤2.00%
Metsoako e setseng
Methanol	≤3000ppm
Ethanol	≤5000ppm
Ethyl Acetate	≤5000ppm
DMF	≤880ppm
Methylbenzene	≤890ppm
Pyridine	≤50ppm
Litaba tsa Metsi (KF)	≤15.0%
Likokoana-hloko tsa Endotoxins	≤3.3EU/mg
Moeli oa Likokoana-hloko	Palo eohle ea Likokoana-hloko ≤100cfu/g
Tekanyetso ea Teko	Maemo a Khoebo;United States Pharmacopoeia (USP) Standard
Tšebeliso	API, Antithrombotic Anticoagulant, Factor Xa Inhibitor

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Fondaparinux Sodium (CAS 114870-03-0) ke sehlopha sa pele sa sehlopha se secha sa antithrombotic anticoagulant ka lik'hemik'hale tse amanang le li-heparin tse boima ba molek'hule (LMWH).Fondaparinux sodium ke factor Xa inhibitor ho theha sebaka se phahameng se tlamang se tlamang bakeng sa anti-coagulant factor antithrombin III (ATIII).Ho tlama ha sodium ea Fondaparinux sebakeng sena ho ka matlafatsa phello ea tlhaho ea ATIII khahlano le factor Xa ka ntlha e ka bang 300, e leng se fellang ka ho thibela tlhahiso ea thrombin.E rekisoa ke GlaxoSmithKline.Phetolelo e akaretsang e entsoeng ke Alchemia e rekisoa ka hare ho US ke Dr. Reddy's Laboratories.Fondaparinux sodium e ile ea hlahisoa ka lekhetlo la pele US bakeng sa prophylaxis of deep vein thrombosis e ka lebisang ho embolism ea pulmonary ka mor'a opereishene e kholo ea masapo.Molek'hule ona oa maiketsetso ke kopi ea tatellano ea heparin pentasaccharide, sekhechana se sekhutšoane se khonang ho etsa hore antithrombin e se ke ea thibela factor Xa ka tsela eo e thibela tlhahiso ea thrombin ntle le ts'ebetso ea antithrombin.