Fondaparinux Sodium CAS 114870-03-0 API
Fana ka Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Fondaparinux Sodium
CAS: 114870-03-0
Antithrombotic Anticoagulant, Factor Xa Inhibitor
API Boleng bo Phahameng, Tlhahiso ea Khoebo
Lebitso la Lik'hemik'hale | Fondaparinux sodium |
Nomoro ea CAS | 114870-03-0 |
Nomoro ea KAtse | RF-API84 |
Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
Foromo ea limolek'hule | C31H43N3O49S8.10Na |
Boima ba Molek'hule | 1728.08 |
Brand | Ruifu Chemical |
Ntho | Litlhaloso |
Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
Mokhoa oa ho hlahloba / oa ho hlahloba | 95.0% ~ 103.0% (ka motheo o omisitsoeng) |
Solubility | E qhibiliha ka Bolokolohi ka Metsing, 2.0M Sodium Chloride le 0.5M Sodium Hydroxide le Insoluble ka Ethanol |
Boitsebiso ba 13C-NMR | Resonances bakeng sa Fondaparinux Sodium e lokela ho hlokomeloa ho 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7, pp.Liphetoho tsa lik'hemik'hale tsa matšoao ana ha li fapane ho feta ± 0.3ppm lipontšo tse ling tsa bophahamo bo fapaneng le liphetoho tsa lik'hemik'hale, tse hlahisoang ke Fondaparinux Sodium, mohlomong e bonoa pakeng tsa 58.0 ~ 80.5 ppm le 98.7 ~ 104.5ppm. |
Boitsebiso ba HPLC | Nako ea ho boloka tlhōrō e kholo ea tharollo ea mohlala e lumellana le ea tharollo e tloaelehileng |
Boitsebiso ba AAS | Sodium e lokela ho ba le mokhoa oa ho monya ho 330.2nm tlas'a qeto ea sodium |
pH | 6.0~8.0 |
Sodium (Na) | 11.5% ~ 15.0% (E balloa ka anhydrous le solvents mahala) |
Sulfate ea mahala | ≤0.30% |
Chloride e setseng | ≤1.00% |
Lintho Tse Amanang | |
Tšilafalo A | ≤0.80% |
Tšilafalo B | ≤0.60% |
Tšilafalo e 'Ngoe | ≤0.30% |
Litšila ka Kakaretso | ≤2.00% |
Metsoako e setseng | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Litaba tsa Metsi (KF) | ≤15.0% |
Likokoana-hloko tsa Endotoxins | ≤3.3EU/mg |
Moeli oa Likokoana-hloko | Palo eohle ea Likokoana-hloko ≤100cfu/g |
Tekanyetso ea Teko | Maemo a Khoebo;United States Pharmacopoeia (USP) Standard |
Tšebeliso | API, Antithrombotic Anticoagulant, Factor Xa Inhibitor |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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Fondaparinux Sodium (CAS 114870-03-0) ke sehlopha sa pele sa sehlopha se secha sa antithrombotic anticoagulant ka lik'hemik'hale tse amanang le li-heparin tse boima ba molek'hule (LMWH).Fondaparinux sodium ke factor Xa inhibitor ho theha sebaka se phahameng se tlamang se tlamang bakeng sa anti-coagulant factor antithrombin III (ATIII).Ho tlama ha sodium ea Fondaparinux sebakeng sena ho ka matlafatsa phello ea tlhaho ea ATIII khahlano le factor Xa ka ntlha e ka bang 300, e leng se fellang ka ho thibela tlhahiso ea thrombin.E rekisoa ke GlaxoSmithKline.Phetolelo e akaretsang e entsoeng ke Alchemia e rekisoa ka hare ho US ke Dr. Reddy's Laboratories.Fondaparinux sodium e ile ea hlahisoa ka lekhetlo la pele US bakeng sa prophylaxis of deep vein thrombosis e ka lebisang ho embolism ea pulmonary ka mor'a opereishene e kholo ea masapo.Molek'hule ona oa maiketsetso ke kopi ea tatellano ea heparin pentasaccharide, sekhechana se sekhutšoane se khonang ho etsa hore antithrombin e se ke ea thibela factor Xa ka tsela eo e thibela tlhahiso ea thrombin ntle le ts'ebetso ea antithrombin.
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