Fulvestrant (ICI 182780) CAS 129453-61-8 API Factory High Quality

Tlhaloso e Khutšoanyane:

Lebitso: Fulvestrant (ICI 182780)

CAS: 129453-61-8

Ponahalo: Bosoeu ho isa ho Bosoeu ba Crystalline Powder

Assay: 97.0% ~ 102.0% (ka motheo o omisitsoeng)

Fulvestrant e sebelisoa kalafong ea mofetše oa matsoele o sa utloeng bohloko ka lihormone ho basali ba kamora ho ilela khoeli.

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

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Tlhaloso:

Phepelo ea Moetsi e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso: Fulvestrant
CAS: 129453-61-8
Fulvestrant e sebelisoa kalafong ea mofetše oa matsoele o sa utloeng bohloko ka lihormone ho basali ba kamora ho ilela khoeli.
API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Fulvesrant
Litlhaloso tse tšoanang	(7α,17β) -7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10) -trien-3,17-diol;ICI 182780
Nomoro ea CAS	129453-61-8
Nomoro ea KAtse	RF-API81
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C32H47F5O3S
Boima ba Molek'hule	606.77
Melting Point	104.0~106.0℃
Solubility	E qhibilihang ka Methanol, Ethanol;Ha e qhibilihe ka Metsing
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu ho isa ho e tšoeu
Boitsebiso	Ka IR, HPLC
Specific Optical Rotation	+108.0 ° ho +115.0 °
Tahlehelo ka ho Omisa	≤0.50%
Masalla a ho Ignition	≤0.10%
6-Keto-Fulvestrant	≤0.10%
6,7-Fulvestrant	≤0.10%
Fulvestrant Sulfone	≤0.20%
Fulvestrant E atolositsoe	≤0.30%
Fulvestrant sterol Dimmer	≤0.80%
Tšilafalo efe kapa efe ea Motho ka Mong e sa Boleloeng	≤0.10%
Litšila ka Kakaretso	≤1.0%
Fulvestrant A	42.0%~48.0%
Fulvestrant B	52.0%~58.0%
DMF	≤620ppm
Litšepe tse boima	≤10ppm
Tlhahlobo	97.0% ~ 102.0% (ka motheo o omisitsoeng)
Polokelo	Boloka ka lebenkeleng le koetsoeng hantle le thibelang khanya le sehatsetsing ka mocheso oa 2 ~ 8 ℃
Tekanyetso ea Teko	United States Pharmacopoeia (USP) Standard
Tšebeliso	Mohanyetsi oa Estrogen Receptor

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Fulvestrant (ICI-182780) CAS 129453-61-8, ke moriana oa ente ea mesifa o entsoeng ke k'hamphani ea AstraZeneca 'me o sebelisoa ho phekola kankere ea matsoele e tsoetseng pele ea li-hormone ho basali ba postmenopausal.Fulvestrant ke eona feela sethethefatsi sa antiestrogen se ka sebelisoang ka bongata ho latela kalafo ea tamoxifen e sa atleheng.Setlhare sena ke mofuta oa phekolo ea endocrine, ka hona se ke ke sa baka litlamorao leha e le life tse atisang ho bonoa chemotherapy, ho fana ka tlhokomelo e ntle ea mokuli.Liteko tse ngata tsa kliniki li fumane hore 250mg Fulvestrant e sebetsa ebile e bolokehile ka mokhoa o tsitsitseng e le mokhoa oa bobeli oa phekolo bakeng sa kankere ea matsoele e tsoetseng pele.Fulvestrant ke mohanyetsi oa maiketsetso oa Estrogen Receptor (ER) ea nang le IC50 ea 0.94 nM tekong ea mahala ea lisele.Fulvestrant e boetse e etsa hore ho be le autophagy le apoptosis mme e na le ts'ebetso ea antitumor.