Gemcitabine CAS 95058-81-4 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Gemcitabine (CAS: 95058-81-4) ka boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Gemcitabine,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Gemcitabine |
| Litlhaloso tse tšoanang | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl) oxolan-2-yl]pyrimidin-2-one;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2', 2'-Difluoro-2'-deoxycytidine;2', 2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Boemo ba Setoko | Ka Setokong, Bokhoni ba Tlhahiso 5 Tons |
| Nomoro ea CAS | 95058-81-4 |
| CAS e amanang le eona | 122111-03-9 |
| Foromo ea limolek'hule | Setšoantšo sa C9H11F2N3O4 |
| Boima ba Molek'hule | 263.20 g/mol |
| Melting Point | 217.0 ho isa ho 222.0 ℃ |
| Botenya | 1.84±0.10 g/cm3 |
| E hloahloa | Mocheso o Mamela |
| Ho qhibiliha ha Metsi | Ha e Monyehe ka Metsing |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | Phofo ea kristale e tšoeu kapa e batlang e le tšoeu, e sa nkheng | E lumellana |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Tšilafalo ea Motho ka Mong | ≤0.10% | 0.03% |
| Litšila ka Kakaretso | ≤1.00% | 0.10% |
| Metsi ka Karl Fischer | ≤1.00% | 0.67% |
| Phetoho e khethehileng | +68.0°~+74.0° | +70,5° |
| Litšepe tse boima | ≤10ppm | <10ppm |
| Masalla a ho Ignition | ≤0.10% | 0.03% |
| Assay (Ka HPLC) | 98.0%~102.0% | 99.9% |
| Infrared Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| 1H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se koetsoe ka thata 'me u se boloke sebakeng sa polokelo se pholileng, se omeletseng le se nang le moea o motle hole le lintho tse sa lumellaneng.Qoba ho pepesehela letsatsi le tobileng, mongobo le mocheso o feteletseng.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Likhoutu tsa Kotsi R21 - E kotsi ha u kopana le letlalo
R36/38 - Ho tena mahlo le letlalo.
R46 - E ka baka tshenyo ya lefutso le lefutso
R62 - Kotsi e ka bang teng ya thari e senyehileng
R63 - Kotsi e ka bang teng ya kotsi ho ngwana ya esong ho hlahe
Tlhaloso ea Tšireletseho S25 - Qoba ho kopana le mahlo.
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36/37 - Apara liaparo tsa tšireletso tse loketseng le liatlana.
S53 - Qoba ho pepeseha - fumana litaelo tse khethehileng pele u li sebelisa.
HS Code 2934999091
Chefo LD10 iv ho likhoto: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) ke meriana ea chemotherapy e sebelisetsoang ho phekola mefuta e mengata ea kankere.Sena se kenyelletsa mofets'e oa matsoele, mofets'e oa matšoafo oa sele e seng nyane, mofets'e oa pancreatic, mofets'e oa senya, le mofets'e oa biliary.Gemcitabine e ntse e batlisisoa hore e sebelisoe mofetšeng oa 'metso,' me e sebelisoa litekong ho li-lymphomas le mefuta e meng e fapaneng ea hlahala.Gemcitabine e tsamaisoa ke tsela ea intravenous, kaha e sebelisoa haholo ke lesela la mala.
Gemcitabine ke analogue ea nucleotide, e leng ea sehlopha sa anti-metabolic sa lithethefatsi tse thibelang mofetše.Haholo-holo e sebetsa ho DNA synthesis phase, ke hore, S phase.Tlas'a maemo a itseng, e ka thibela karolo ea G1 ho fetela ho S phase.E na le litšobotsi tse fapaneng tsa anticancer spectrum, mokhoa o ikhethileng oa ts'ebetso, chefo e tlase, ha e hanyetsane le lithethefatsi tse ling tsa chemotherapy ebile ha e na chefo e phahameng.Chemicalbook, gemcitabine, e se e amohetsoe hore e sebelisoe linaheng tse fetang 90, e leng se etsang hore e be eona kalafo ea pele bakeng sa mofetše oa matšoafo oa sele e seng e nyane le "tekanyetso ea khauta" bakeng sa mofetše oa pancreatic.
Ka 1999, CFDA e amohetse gemcitabine bakeng sa phekolo ea NSCLC ea sebakeng sa heno e tsoetseng pele kapa ea metastatic, kankere ea pancreatic e tsoetseng pele kapa ea metastatic;Ka 2010, CChemicalbookFDA e ile ea amohela gemcitabine hammoho le paclitaxel bakeng sa kalafo ea mofetše oa matsoele o sa tsitsang, o iphetang kapa oa metastatic o iphetileng kamora chemotherapy ea adjuvant/neoadjuvant.
Gemcitabine ke analogue e pharaletseng ea antimetabolite le deoxycytidine e nang le ts'ebetso ea antineoplastic.Ha e sebelisoa, gemcitabine e fetoloa metabolites e sebetsang ea difluorodeoxycytidine diphosphate (dFdCDP) le difluorodeoxycytidine triphosphate (dFdCTP) ka deoxycytidine kinase.dFdCTP e qothisana lehlokoa le deoxycytidine triphosphate (dCTP) 'me e kenyelelitsoe ho DNA.Sena se notlela DNA polymerase ka hona se fella ka ho felisoa ha maske nakong ea ho ikatisa ha DNA.Ka lehlakoreng le leng, dFdCDP e thibela ribonucleotide reductase, kahoo e fokotsa letamo la deoxynucleotide le fumanehang bakeng sa motsoako oa DNA.Ho fokotseha ha khatello ea intracellular ea dCTP ho ka etsa hore dFdCTP e kenyelletsoe ho DNA.
