H-Gly-OMe·HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay >99.0%

1. Thepa: Sehlahisoa sena e lokela ho ba phofo e tšoeu ea kristale.
2. Tlhahlobo:
1) Boikemisetso ba tlhahlobo ea Glycine Methyl Ester Hydrochloride
1.1 Mokhoa
Tlas'a maemo a acidic, sampole e arabela ka bongata bo itseng ba nitrate ea silevera, 'me nitrate ea silevera e feteletseng e khutlisetsoa ka ammonium thiocyanate, e buang ka ammonium ferric sulfate.
E le sesupo, kakaretso ea chlorine e ile ea khethoa ho latela boholo ba tharollo e tloaelehileng e sebelisitsoeng, 'me kakaretso ea chlorine e ile ea tlosoa ho glycine hydrochloride ho fumana Glycine Methyl Ester Hydrochloride content.
1.2 Li-reagents
Dibutyl phthalate;
Tharollo ea nitric acid: 2 + 3;
Silver nitrate standard titration solution: c(AgNO3) = 0.1 mol/L
Ammonium thiocyanate tharollo e tloaelehileng ea titration: c(NH4SCN) = 0.1 mol/L
Ammonium ferric sulfate (III) seela sa pontšo: 80 g/L
1.3 Mokhoa oa ho hlahloba
Kala ka 0.5g sampole, nepahetseng ho 0.0001g.Beha ka har'a 250ml conical flask, qhala ka metsing a 40ml, eketsa 10 ml nitric acid solution, Add (50 ± 0.02) mL silver nitrate standard titration solution, 3mL ammonium ferric sulfate indicator solution, 4mL dibutyl phthalate, le thiocyanate solution ea thiocyanate Ammonium. titrated ho fihlela tharollo e le sootho e khanyang 'me e lula e se na mebala bakeng sa 30 s.
1.4 Palo ea sephetho
Karolo e boima ea glycine methyl ester hydrochloric acid content w1, e hlahisoang e le %, e baloa ho latela Equation (1) :
w1= (c1V1-c2V2)*M/1000/m * 100-w2 *1.126 foromo (1)
Moo:
V1: Bophahamo ba silevera ea nitrate standard titration solution (ml)
V2: Bolumo ea ammonium thiocyanate standard titration solution e sebelisoang ke titration (ml)
c1: Boleng bo nepahetseng ba silver nitrate standard titration solution (mol/L)
c2: Boleng bo nepahetseng ba ammonium thiocyanate standard titration solution (mol/L)
w2: Karolo ea boima (%) ea glycine hydrochloride content joalokaha ho khethiloe Karolong ea 4.2
M: boima ba 'mele oa glycine methyl ester hydrochloride (g/mol)
1.126: Phetoho ea coefficient ea glycine hydrochloride ho Glycine methyl ester hydrochloride.
Boleng ba palo ea lipalo tsa liphetho tse peli tse bapang bo nkuoe e le sephetho sa tekanyo, 'me phapang e felletseng lipakeng tsa liphetho tse peli tse bapileng e ne e sa fete 0.05%.
2) Boikemisetso ba litaba tsa glycine hydrochloride
2.1 Mokhoa
Ho sebelisoa dimethyl yellow e le sesupo, sampole e ne e tšeloa ka sodium hydroxide standard titrating solution, 'me bophahamo ba tharollo bo ne bo tekiloe ho latela tšebeliso ea sodium hydroxide standard.
Lekola litaba tsa glycine hydrochloride.
2.2 Reagent
Tharollo e tloaelehileng ea titration ea sodium hydroxide: c (NaOH) = 0.1mol/L
Seela se sesupo sa Dimethyl: 10 g/L
2.3 Mokhoa oa ho hlahloba
Beakanya sampole ea laboratori ea 5.0 g, e nepahetseng ho isa ho 0.0001g, ka bekeng ea 200 ml, qhala ka metsi a 50ml, 'me u kenye marotholi a 5 a dimethyl.
Mokelikeli o mosehla, o nang le sodium hydroxide standard titration solution titration ho fihlela tharollo ho tloha ho khubelu ho ea ho mosehla oa lamunu ke ntlha ea ho qetela.
2.4 Palo ea Liphetho
Karolo e boima ea w2 ea glycine hydrochloride content e hlahisoa e le % 'me e baloa ho latela Equation (2):
w2 =(V/1000)cM/m *100 foromo (2)
Moo:
V: Bophahamo ba sodium hydroxide standard titration solution (mL)
c: Boleng bo nepahetseng ba sodium hydroxide standard titration solution (mol/L)
M: boima ba 'mele oa glycine hydrochloride (g/mol)
m: Boleng ba boleng ba sampole (g)
Boleng ba palo ea lipalo tsa liphetho tse peli tse bapang bo nkuoe e le sephetho sa tekanyo, 'me phapang e felletseng lipakeng tsa liphetho tse peli tse bapileng e ne e sa fete 0.05%
3. Sebaka sa ho qhibiliha: Ho ea ka mokhoa oa ho tiisa ntlha ea ho qhibiliha (Chinese Pharmacopoeia 2010 Appendix VIC), sebaka sa ho qhibiliha ke 172-178 ºC.
4. Ho omisa boima ba 'mele: nka sehlahisoa sena ho 105.0℃' me u se omise ho boima bo sa feleng.Ho theola boima ba 'mele ha hoa lokela ho feta 0.5%.
5. Polokelo: Sehlahisoa sena se lokela ho ba sehatsetsing hole le leseli.