N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Tlhahiso ea Khoebo ea Imatinib Mesylate le Li-Intermediates tse Amanang:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Lebitso la Lik'hemik'hale | N-(5-Amino-2-methylphenyl) -4-(3-pyridyl) -2-pyrimidinea |
| Litlhaloso tse tšoanang | Imatinib Mesylate Mahareng;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Nomoro ea CAS | 152460-10-1 |
| Nomoro ea KAtse | RF-PI230 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C16H15N5 |
| Boima ba Molek'hule | 277.32 |
| Melting Point | 133.0-135.0 ℃ |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Orange e Khanyang ho ea ho phofo e mosehla ho ea ho Crystal |
| Mokhoa oa Bohloeki / Analysis | ≥98.0% |
| Tahlehelo ka ho Omisa | ≤0.50% |
| Masalla ha a tuka | ≤0.50% |
| Litšila ka Kakaretso | ≤2.0% |
| Ho se hloeke ho hoholo ho le Mong | ≤1.0% |
| Litšepe tse boima | ≤20ppm |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Bohareng ba Imatinib Mesylate (CAS: 220127-57-1) |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) ea boleng bo holimo. .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) ke ea mahareng ka tloaelo ho motsoako oa Imatinib Mesylate (CAS: 220127-57-1) ) API.
Imatinib mesylate ke molek'hule e nyane e thibelang c-Abl protein-tyrosine kinase, kinase e bohlokoa ka ho khetheha bakeng sa ho ata ha leukemia e sa foleng ea myelogenous (CML).Ketsahalo ea phetoho lipakeng tsa chromosome 9 le 22 e hlahisa Philadelphia chromosome, e ntan'o hlahisa protheine ea Bcr-Abl fusion e nang le ts'ebetso ea aberrant kinase e khothalletsang ho ata ha lisele ka potlako.Imatinib mesylate e tlama kinase ena ea bohlokoa, e emisa kholo e amanang le CML.Imatinib mesylate e boetse e bontšitsoe ho thibela PDGFR le tyrosine kinases e amanang le c-Kit.Meetso e nang le Imatinib mesylate e sebelisitsoe kalafong ea mefuta e fapaneng ea mofetše.
Imatinib mesylate ke tyrosine kinase inhibitor.E totobetse haholo bakeng sa BCR-ABL, enzyme e amanang le leukemia e sa foleng ea myelogenous (CML) le mefuta e itseng ea acute lymphoblastic leukemia (ALL).Ke v-Abl tyrosine kinase inhibitor e matla le e khethang (IC50 = 38 nM).E boetse e thibela PDGFR le c-kit.E bonts'a khetho ea v-Abl holim'a phanele ea tyrosine e 'ngoe le serine/threonine protein kinases.Ka mokhoa o ikhethileng e thibela kholo e hlohlellelitsoeng ea PDGF ea lisele tsa PB-3 tse fetotsoeng v-abl le V-sis-transformed BALB/c 3T3 cell in vitro.E bonts'a litlamorao tsa antitumor ho litoeba tse nang le AMuLV kapa BABL/c 3T3 v-sis liseleng.E thibela ho ikatisa ha SARS-CoV le MERS-CoV in vitro (litekanyetso tsa EC50 ke 9.823 le 17.689 μM, ka ho latellana).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Bohloeki](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)