Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Tlhahiso ea Khoebo ea Imatinib Mesylate le Li-Intermediates tse Amanang:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Lebitso la Lik'hemik'hale | Imatinib Mesylate (mofuta oa alpha) |
| Litlhaloso tse tšoanang | imatinib methanesulfonate;STI571 Mesylate;CGP-57148B |
| Nomoro ea CAS | 220127-57-1 |
| Nomoro ea KAtse | RF-API19 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | Setšoantšo sa C30H35N7O4S |
| Boima ba Molek'hule | 589.71 |
| Boemo ba ho Romela | Tlas'a Mocheso oa Ambient |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu |
| Solubility | Ho bonolo ho qhaqha ka metsing |
| Boitsebiso ba HPLC | Nako ea ho boloka boholo ba spectrum spectrum e lumellana le seo |
| Boitsebiso ba IR | Sekhahla sa ho monya sa infrared sa sampole se lumellana le sampole ea litšupiso |
| Melting Point | 214.0~222.0℃ |
| Tahlehelo ka ho Omisa | ≤0.50% |
| Masalla a ho Ignition | ≤0.10% |
| Litšepe tse boima | ≤20ppm |
| Lintho Tse Amanang | (1) Tšilafalo G: NMT 0.3% |
| (2) Tšilafalo B: NMT 0.3% | |
| (3) Tšilafalo C: NMT 0.3% | |
| (4) Tšilafalo D: NMT 0.3% | |
| (5) Tšilafalo A: NMT 0.3% | |
| (6) Tšilafalo H: NMT 0.3% | |
| (7) Tšilafalo F: NMT 0.3% | |
| (8) Tšilafalo E: NMT 0.3% | |
| (9) Tšilafalo e kholo ka ho fetisisa e le 'ngoe: NMT0.1% | |
| Metsoako e setseng | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Tlhahlobo ea HPLC | 98.0% ~ 102.0% (C30H35N7SO4 E Baloang ka Motheo oa Anhydrous) |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | API;Ph+CML |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Imatinib Mesylate (CAS 220127-57-1) ke molek'hule e nyenyane e thibelang c-Abl protheine-tyrosine kinase, kinase ea bohlokoa ka ho khetheha bakeng sa ho ata ha leukemia e sa foleng ea myelogenous (CML).E khethehileng haholo bakeng sa BCR-ABL, enzyme e amanang le leukemia e sa foleng ea myelogenous (CML) le mefuta e itseng ea acute lymphoblastic leukemia (ALL).Ke v-Abl tyrosine kinase inhibitor e matla le e khethang (IC50 = 38 nM).Ketsahalo ea phetisetso lipakeng tsa chromosome 9 le 22 e hlahisa Philadelphia chromosome, e ntan'o hlahisa protheine ea Bcr-Abl fusion e nang le ts'ebetso ea aberrant kinase e khothalletsang ho ata ha lisele ka potlako.Imatinib mesylate e tlama kinase ena ea bohlokoa, e emisa kholo e amanang le CML.Imatinib mesylate e boetse e bontšitsoe ho thibela PDGFR le tyrosine kinases e amanang le c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Bohloeki](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)