Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Baetsi ba Lihlahisoa tsa Irinotecan le Li-intermediates tse Amanang:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Lebitso la Lik'hemik'hale | Irinotecan Hydrochloride |
| Litlhaloso tse tšoanang | Camptothecin II;CPT-II |
| Nomoro ea CAS | 100286-90-6 |
| Nomoro ea KAtse | RF-API50 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C33H39ClN4O6 |
| Boima ba Molek'hule | 623.15 |
| Melting Point | 250-256 ℃ (Dec.) |
| Maemo a polokelo | Tlas'a Mocheso oa Ambient |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e tšoeu kapa e sa bosoeu |
| Solubility | E qhibiliha ka metsing le methanol, e qhibiliha hanyenyane ka chloroform, ethanol |
| Boitsebiso ba IR | Sekhahla sa ho monya sa infrared sa sampole ea teko se lokela ho lumellana le maemo a litšupiso |
| Boitsebiso ba HPLC | Nako ea ho boloka tlhōrō e kholo ea tharollo ea mohlala e lokela ho lumellana le ea litekanyetso tsa litšupiso. |
| Boitsebiso | E kopana le litlhokahalo tsa liteko tsa chloride Positive reaction |
| Mongobo (KF) | 7.0%~9.0% w/w |
| Masalla a ho Ignition | ≤0.10% |
| Litšepe tse boima | ≤20ppm |
| Enantiomer ea Irinotecan Hydrochloride | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Tšilafalo efe kapa efe e sa Boleloeng | ≤0.10% |
| Litšila ka Kakaretso | ≤0.50% |
| Residual Solvents (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Likokoana-hloko tsa Endotoxins | ≤0.29 EU/mg Irinotecan |
| Meeli ea Likokoana-hloko | Kakaretso ea Palo ea Aerobic Microbial: <1000 cfu/g |
| Hlobo le Litomoso | <100 cfu/g |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC, motheong oa anhydrous) |
| Tekanyetso ea Teko | United States Pharmacopeia (USP) Standard |
| Tšebeliso | Active Pharmaceutical ingredient (API) |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
lrinotecan hydrochloride (CAS 100286-90-6), semi-synthetic, e nkiloeng ka metsi ho tsoa ho camptothecin e matla ea anticancer, e hlahisitsoe Japane bakeng sa kalafo ea mofets'e oa matšoafo, mahe a bomme le a popelo.lrinotecan e fana ka ts'ebetso ea eona ea antitumor ka ho thibela topoisomerase I, e leng enzyme ea cellular e amehang ho boloka sebopeho sa topographic ea DNA nakong ea ho fetolela, ho ngoloa le mitosis.lrinotecan e etsa de-esterification in vivo ho hlahisa metabolite e sebetsang, SN-38, e matla ho feta motsoali ka makhetlo a 1000.Kalafo e kopantseng ea irinotecan le e 'ngoe e sebelisoang haholo e thibelang mofetše, cisplatin, e tlalehiloe e phahametse moemeli a le mong.lrinotecan e litekong tsa bongaka bakeng sa mala, letsoele, letlalo, colorectal, kankere ea pancreatic, mesothelioma le non-Hodgkin's lymphoma.
