Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Baetsi ba Lihlahisoa tsa Irinotecan le Li-intermediates tse Amanang:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Lebitso la Lik'hemik'hale | Irinotecan Hydrochloride Trihydrate |
| Litlhaloso tse tšoanang | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Nomoro ea CAS | 136572-09-3 |
| Nomoro ea KAtse | RF-API52 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C33H38N4O6·HCl·3H2O |
| Boima ba Molek'hule | 677.20 |
| Melting Point | 250.0~256.0℃ (Dec.) |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea kristale e Khanyang kapa e Sehla |
| Tlhahlobo (w/w) | 98.0%~102.0% |
| Purity (HPLC) | ≥99.5% |
| Solubility | E qhibiliha hanyane ka metsing, ethanol kapa chloroform, Ha e khone ho qhibiliha ka har'a acetone |
| Boitsebiso | ka IR le HPLC, Conforms |
| Specific Optical Rotation | +60°~+73° |
| Metsi | 7.0%~9.0% |
| Mesala ea Litlhapi | E lumellana le Litlhokahalo tsa ICH |
| Masalla a ho Ignition | ≤0.20% |
| Chloride | 5.0%~6.0% |
| pH Boleng | 3.0~5.0 |
| Litšepe tse boima | ≤20ppm |
| Litšila tsa Motho ka Mong | ≤0.10% |
| Litšila ka Kakaretso | ≤0.50% |
| Boemo ba polokelo | Boloka ka 2-8 ° C, Ka lijaneng tse tiisitsoeng 'me u sireletse khanya le mongobo |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Active Pharmaceutical ingredient (API) |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) e nang le boleng bo phahameng.
Irinotecan Hydrochloride Trihydrate ke topoisomerase I inhibitor haholo-holo e sebelisetsoang ho phekola mofetše oa mala le mofets'e oa rectal, e thibelang ho ikamahanya le lesela la DNA ka ho tlama topoisomerase I-DNA complex.lrinotecan hydrochloride, semi-synthetic, e nkiloeng ka metsi e tsoang ho camptothecin e matla ea anticancer, e ile ea hlahisoa Japane bakeng sa kalafo ea mofets'e oa matšoafo, oa mahe a bomme le a molomo oa popelo.lrinotecan e fana ka ts'ebetso ea eona ea antitumor ka ho thibela topoisomerase I, e leng enzyme ea cellular e amehang ho boloka sebopeho sa topographic ea DNA nakong ea ho fetolela, ho ngoloa le mitosis.lrinotecan e etsa de-esterification in vivo ho hlahisa metabolite e sebetsang, SN-38, e matla ho feta motsoali ka makhetlo a 1000.Leha e le chefo e nyane ho feta camptothecin, palo e kholo ea bakuli litekong tsa bongaka e bontšitse litlamorao tsa leukopenia, letšollo, ho nyekeloa ke pelo le alopecia.Kalafo e kopantseng ea irinotecan le e 'ngoe e sebelisoang haholo e thibelang mofetše, cisplatin, e tlalehiloe e phahametse moemeli a le mong.lrinotecan e litekong tsa bongaka bakeng sa mala, letsoele, letlalo, colorectal, kankere ea pancreatic, mesothelioma le non-Hodgkin's lymphoma.
