Ketorolac Tromethamine CAS 74103-07-4 Purity >99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea Ketorolac Tromethamine Salt (CAS: 74103-07-4) e nang le boleng bo phahameng.Re ka fana ka COA, phano ea lefats'e ka bophara, tse nyane le tse ngata tse fumanehang.Haeba u thahasella sehlahisoa sena, ka kopo romella lintlha tse qaqileng ho kenyelletsa nomoro ea CAS, lebitso la sehlahisoa, bongata ho rona.Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Ketorolac Tromethamine |
| Litlhaloso tse tšoanang | Ketorolac Tris Letsoai;Ketorolac (Tromethamine Letsoai);rac Ketorolac Tromethamine Letsoai;Toradol;(±) -5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris Letsoai;(±) -Sebopeho sa Letsoai la Tromethamine |
| Nomoro ea CAS | 74103-07-4 |
| Boemo ba Setoko | In Stock, Commercially Manufactured |
| Foromo ea limolek'hule | C15H13NO3·C4H11NO3 |
| Boima ba Molek'hule | 376.41 |
| Melting Point | 160.0 ~ 161.0℃ |
| Ntlha e belang | 493.2 ℃ ho 760 mmHg |
| E hloahloa | Hygroscopic.Khanya e Imamela |
| λmax | 322nm(MeOH)(lit.) |
| COA & MSDS | E fumaneha |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu |
| pH | 5.7~6.7 |
| Melting Point | 160.0 ~ 161.0℃ |
| Mokhoa oa Bohloeki / Analysis | >99.0% (HPLC) |
| Mokhoa oa ho hlahloba / oa ho hlahloba | 98.5 ~ 101.5% (E baloa ka Motheo o Omisitsoeng) |
| Tahlehelo ka ho Omisa | <0.50% |
| Masalla a ho Ignition | <0.10% |
| Litšepe tse boima (Pb) | ≤20ppm |
| Lintho Tse Amanang | |
| Ho se hloeke RRT0.54 | <0.50% |
| Ho se hloeke RRT0.66 | <0.50% |
| Ketorolac 1-Keto Analoge | <0.10% |
| Ketorolac 1-Hydroxy Analog | <0.10% |
| Tšilafalo efe kapa efe e 'Ngoe | <0.20% |
| Litšila ka Kakaretso | <1.00% |
| Metsoako e setseng | |
| Dichloroethane | <50ppm |
| Ethanol e se nang metsi | <5000ppm |
| Meeli ea Likokoana-hloko | |
| Chelete ea Libaktheria | <1000cfu/g |
| Hlobo le Tomoso Chelete | <100cfu/g |
| Escherichia.Coli | Absent |
| Endotoxin ea baktheria | <5EU/mg |
| Infrared Spectrum | E Ikamahanya le Sebopeho |
| Sollubility ho H2O | E se Na Mebala ho isa ho Faint Yellow Clear (15 mg/ml) Pass |
| Tekanyetso ea Teko | Maemo a Khoebo |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka setshelo se koetsoeng ka thata.Boloka sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Ketorolac Tromethamine Letsoai (CAS: 74103-07-4) ke ntho e seng ea steroidal e thibelang ho ruruha e bontšang ts'ebetso ea analgesic le antipyretic.Ke COX inhibitor e sa khetheng e nang le IC50s ea 20 nM bakeng sa COX-1 le COX-2 ka bobeli.Ketorolac Tromethamine Letsoai le atleha ho laola bohloko bo itekanetseng ho isa ho bo matla ka mor'a ho buuoa.Leha ho le joalo, ke ea pele ea mofuta ona oa moemeli ho tsamaisoa ka botsoali e le setlhare, 'me e bontšoa ka ho khetheha bakeng sa ente ea intramuscular.Ketorolac ke mokhoa o mong o sebetsang ho li-analgesics tsa narcotic ka lebaka la khaello ea eona ea tlhekefetso.E sebelisoa haholo-holo bakeng sa litlamorao tsa eona tsa analgesic bakeng sa kalafo ea nako e khuts'oane ea bohloko bo bobebe ho isa ho bo itekanetseng ho lintja le litoeba.Nako ea phello ea analgesic ho lintja ke hoo e ka bang lihora tse 8-12, empa ka lebaka la ho fumaneha ha li-NSAID tse amohelehang, tse sireletsehileng bakeng sa lintja, tšebeliso ea eona ea belaella.Letsoai la organoammonium le hlahisoang ke motsoako oa palo e lekanang ea ketorolac le tromethamine (tris).E na le li-analgesic tse matla tse se nang sedating le li-anti-inflammatory tse itekanetseng.E sebelisoa taolong ea nako e khuts'oane ea mahlaba a kamora ho buuoa, le marotholing a mahlo ho imolla ho hlohlona ha mahlo ho amanang le nako ea selemo ea allergic conjunctivitis.
Matšoao a Kotsi T - Chefo
Likhoutu tsa Kotsi
R25 - E chefo ha e koetsoe
R36/37/38 - Ho hlohlona mahlong, tsamaiso ya moya le letlalo.
R23/24/25 - Chefo ka ho hema, ka ho kopana le letlalo le haeba e koetsoe.
Tlhaloso ea Tšireletseho
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
S36/37/39 - Apara liaparo tse loketseng tse sireletsang, liatlana le tšireletso ea mahlo / sefahleho.
Li-ID tsa UN UN 2811 6.1/PG 3
WGK Jeremane 3
RTECS UY7759900
HS Code 2933995500
Sehlopha sa Likotsi 6.1(a)
Sehlopha sa ho paka II
Ketorolac Tromethamine ha e na ka tlase ho liphesente tse 98.5 le eseng ho feta 101.5 lekholong ea C15H13NO3 · C4H11NO3, e baloang motheong o omisitsoeng.
Ho paka le ho boloka-Ho boloka ka har'a lijana tse thata, tse sa keneleng khanya.Boloka ho 25°, maeto a lumelloang lipakeng tsa 15° le 30°
USP Reference standards <11>-
USP Ketorolac Tromethamine RS
Boitsebiso-
A: Infrared Absorption <197K>.
B: Ho Monyeha ha Ultraviolet <197U>-
Tharollo: 10 µg ka mL
Hare: methanol.
C: Teko ea Tromethamine-Lokisetsa tharollo e tloaelehileng ea USP Ketorolac Tromethamine RS ka motsoako oa dichloromethane le methanol (2: 1) e nang le 5 mg ka mL.Ka mokhoa o ts'oanang, lokisetsa tharollo ea teko ea Ketorolac Tromethamine e nang le 5 mg ka mL.Sebelisa meqolo ea 40-µL ea tharollo e Tloaelehileng le tharollo ea teko ho poleiti ea chromatographic ea lera le tšesaane (sheba Chromatography <621>) e koahetsoeng ka lera la 0.25-mm ea motsoako oa silika oa chromatographic.Beha poleiti ka phaposing ea chromatographic eo pele e neng e kopantsoe le motsoako oa dichloromethane, acetone, le glacial acetic acid (95:5:2).Tiisa kamore, 'me u ntlafatse chromatogram ho fihlela karolo e ka pele ea mokelikeli e tsamaea hoo e ka bang likarolo tse tharo ho tse 'nè tsa bolelele ba poleiti.Tlosa poleiti ka kamoreng, 'me u lumelle solvent hore e fetohe mouoane.Fafatsa poleiti ka tharollo ea tahi e sa tsoa lokisoa e nang le 30 mg ea ninhydrin ka mL, 'me u chese poleiti ka hoo e ka bang 150 ° metsotso e 2 ho isa ho e 5.Matheba a mosehla a nang le meedi e pinki ho isa ho pherese a hlaha poleiting libakeng tseo ho tsona ho sebelisitsoeng tharollo ea Standard le tharollo ea teko.
pH <791>: pakeng tsa 5.7 le 6.7, ka tharollo (1 ho 100).
Tahlehelo ha o omisa <731> -E omise ka vacuum ka 60 ° bakeng sa lihora tse 3: ha e lahlehe ho feta 0.5% ea boima ba eona.
Masala a ho khantša <281>: eseng ho feta 0.1%.
Litšepe tse boima, Mokhoa oa II <231>: 0,002%.
Bohloeki ba Chromatographic-
Mohato oa selefouno, motsoako oa Solvent, tokisetso e tloaelehileng, tharollo ea Resolution, le tsamaiso ea Chromatographic-Tsoela pele joalokaha ho laetsoe ho Assay.
Tharollo ea teko-Sebelisa ho lokisetsa Assay.
Procedure-Chromatograph Tharollo ea Teko joalo ka ha e laetsoe Ts'ebetso ho Assay, e lumellang chromatography hore e fetele makhetlo a mararo ho feta nako ea ho boloka ketorolac.Lekanya likarabo tsa litlhōrō tsohle.Bala liperesente tsa ho se hloeke ha motho ka mong karolong ea Ketorolac Tromethamine e nkiloeng ka foromo:
100rfi (ri / rs)
moo rfi e leng lebaka la karabelo ea tlhoro e 'ngoe le e' ngoe ea litšila tse amanang le ketorolac;ri ke tlhōrō ea karabelo bakeng sa litšila ka 'ngoe;'me rs ke kakaretso ea likarabelo tsohle tsa tlhoro ea litlhoro tsa ho se hloeke le tlhoro e kholo ea ketorolac.Litekanyetso tsa rfi ke 0.52 bakeng sa analogue ea ketorolac 1-keto, 0.67 bakeng sa analog ea ketorolac 1-hydroxy, 2.2 bakeng sa tlhoro ea litšila e nang le nako ea ho bolokoa ea 0.54 ha e bapisoa le ea ketorolac, le 0.91 bakeng sa tlhoro ea ho se hloeke ka nako e itseng. ea 0.66.Ha e fumanehe ho feta 0.1% ea analogue ea ketorolac 1-keto kapa ea analogue ea ketorolac 1-hydroxy;ha ho fete 0.5% ea litšila tse ling tse fumanoang;mme kakaretso ya ditshila tsohle ha e fete 1.0%.
Tlhahlobo-
Mobile phase-Hlakola 5.75 g ya monobasic ammonium phosphate ka 1000 mL ea metsi, 'me u ikamahanye le phosphoric acid ho pH ea 3.0.Lokisetsa motsoako o tlhotliloeng le o senyehileng oa tharollo ena ea buffer le tetrahydrofuran (70:30).Etsa litokiso ha ho hlokahala (sheba Sistimi Suitability tlas'a Chromatography <621>) ho fihlela nako ea ho boloka ketorolac ea metsotso e ka bang 8 ho isa ho e 12.
Motsoako oa Solvent-Lokisetsa motsoako oa metsi le tetrahydrofuran (70:30).
Tlhophiso e tloaelehileng-Qhololla ka mokhoa o nepahetseng tekanyo e lekantsoeng ea USP Ketorolac Tromethamine RS ka motsoako oa Solvent ho fumana tharollo e nang le mahloriso a tsebahalang a ka bang 0.4 mg ka mL.[HLOKOMELA-Sireletsa tharollo ena khanyeng.]
Assay preparation-Fetisetsa hoo e ka bang 20 mg ea Ketorolac Tromethamine, e lekantsoeng ka nepo, ho botlolo ea volumetric ea 50-mL, hlapolla ka motsoako oa Solvent ho ea bophahamong, 'me u kopanye.[HLOKOMELA-Sireletsa tharollo ena khanyeng.]
Tharollo ea tharollo-Motsoakong oa karohano ea 250-mL 100 mL ea metsi, 100 mL ea dichloromethane, 30 mg ea USP Ketorolac Tromethamine RS, le 1 mL ea 1 N hydrochloric acid.Kenya setopo, sisinya, 'me u lumelle hore lihlopha li arohane.Fetisetsa lera le ka tlaase la dichloromethane ho botlolo ea khalase ea borosilicate e emisitsoeng, 'me u lahle karolo e ka holimo.Hlahisa tharollo ea dichloromethane ho lebisa khanya ea letsatsi metsotso e 10 ho isa ho e 15.Fetisetsa 1.0 mL ea tharollo ka har'a vial, e fetoha mouoane moeeng oa moea kapa ka har'a molatsoana oa naetrojene ho omella, eketsa 1.0 mL ea motsoako oa Solvent, 'me u tsubelle ho qhibiliha.[HLOKOMELA-Tharollo ena e ka bolokoa tlas'a sehatsetsi 'me ea sebelisoa hafeela chromatogram e fumanoeng joalokaha e laetsoe bakeng sa Tsamaiso e loketse ho khetholla litlhōrō ka lebaka la ketorolac 1-keto analog le ketorolac 1-hydroxy analog, le bakeng sa tekanyo ea qeto. pakeng tsa ketorolac 1-keto analog le ketorolac.]
Chromatographic system (sheba Chromatography <621>)—Mokelikeli oa chromatograph o na le detector ea 313-nm le kholomo ea 4.6-mm × 25-cm e nang le 5-µm packing L7 'me e bolokiloe mocheso o sa khaotseng oa hoo e ka bang 40°.Sekhahla sa phallo ke hoo e ka bang 1.5 mL ka motsotso.Chromatograph tharollo ea Qeto, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe Mokhoa: nako ea ho boloka e lekanyelitsoeng e ka ba 0.63 bakeng sa analoge ea ketoroac 1-hydroxy, 0.89 bakeng sa analoge ea ketorolac 1-keto, le 1.0 bakeng sa ketorolac;'me qeto, R, pakeng tsa analoge ea ketorolac 1-keto le ketorolac ha e ka tlaase ho 1.5.Chromatograph ea Boitokisetso ba Maemo, le ho tlaleha likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: katleho ea kholomo ha e ka tlase ho lipoleiti tsa theory tsa 5500;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 1.5%.
Ts'ebetso-Ka karohano kenya li-volume tse lekanang (tse ka bang 10 µL) tsa tokisetso e tloaelehileng le boitokisetso ba Assay ho chromatograph, rekota li-chromatogram, 'me u lekanye likarabo tsa litlhoro tse kholo.Bala palo, ka mg, ea C15H13NO3·C4H11NO3 karolong ea Ketorolac Tromethamine e nkiloeng ka foromo:
50C(rU / rS)
eo ho eona C e leng mahloriso, ka mg ka mL, ea USP Ketorolac Tromethamine RS ka ho lokisetsa Standard;'me rU le rS ke likarabelo tsa tlhoro ea ketorolac tse fumanoeng ho tsoa ho tokiso ea Assay le ho hlophisoa ha Standard, ka ho latellana.
