Levodopa (L-DOPA) CAS 59-92-7 99.0~100.5% USP BP EP Standard Anti-Parkinson's Disease High Purity
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea Levodopa (L-DOPA) (CAS: 59-92-7) e nang le boleng bo phahameng, Boloetse ba Anti-Parkinson.Joaloka e mong oa barekisi ba kholo ka ho fetisisa ba Levodopa Chaena, Ruifu Chemical e fana ka Levodopa e tšoanelehang ho fihlela litekanyetso tsa machaba, tse kang AJI, USP, EP, BP le IP standard.Bokhoni ba tlhahiso ea lithane tse 300 ka selemo.Re ka fana ka COA, phano ea lefats'e ka bophara, tse nyane le tse ngata tse fumanehang.Haeba u thahasella Levodopa,Please contact: alvin@ruifuchem.com
Lebitso la Lik'hemik'hale | Levodopa |
Litlhaloso tse tšoanang | L-DOPA;3-(3,4-Dihydroxyphenyl) -L-Alanine;L-3-(3,4-Dihydroxyphenyl)alanine;3,4-L-Dihydroxyphenylalanine;3-Hydroxy-L-Tyrosine;L-3-Hydroxytyrosine;H-Tyr(3-OH)-OH |
Nomoro ea CAS | 59-92-7 |
Nomoro ea KAtse | RF-API55 |
Boemo ba Setoko | Ka Setokong, Bokhoni ba Tlhahiso Lithane tse 300 ka Selemo |
Foromo ea limolek'hule | C9H11NO4 |
Boima ba Molek'hule | 197.19 |
Melting Point | 276.0~278.0℃(lit.) |
E hloahloa | E Mamela Khanya, E Mamela Moea |
Sollubility ka Metsing | Hanyane ka Metsing |
Solubility | Ha e qhibilihe ka har'a Chloroform, Ethanol, Benzene, Ether. |
Sollubility ho 1mol/L HCl | E qhibiliha ka Dilute Hydrochloric Acid.Hoo e ka bang Ponaletso |
Botsitso | E tsitsitseng.Ha e tsamaellane le li-Agent tse Matla tsa Oxidizing.Leseli le Moeeng ha Li Mamele |
Brand | Ruifu Chemical |
Ntho | Litlhaloso |
Ponahalo | Phofo ea Crystalline e tšoeu kapa ea Lebese |
Boitsebiso | Infrared Absorption Spectrum |
Optical Rotation [α]20/D | -1,27 ° ho -1,34 ° |
Ponahalo ea Tharollo | E Feta Teko |
Boholo ba Karolo | 100% Feta 80 |
Lintho Tse Amanang | |
L-Tyrosina | ≤0.10% |
Motsoako oa Levodopared | ≤0.10% |
3-Methoxytyrosine | ≤0.50% |
Litšila ka Kakaretso | ≤1.00% |
Litšila Tse sa Tsejoeng | ≤0.10% |
UV Spectrum MaxE1%1cm | 137~147 (280nm) |
Heavy Metals (as Pb) | ≤10ppm |
Tahlehelo ka ho Omisa | ≤1.00% (ho 105℃ bakeng sa Lihora tse 4) |
Residue on Ignition (Sulfated) | ≤0.10% |
Tlhahlobo | 99.0%~100.5% |
PH | 4.5~7.0 (0.10g ho 10ml ea H2O Ho sisinyeha ka Metsotso e 15) |
Tekanyetso ea Teko | AJI/USP/BP/EP/IP/JP Standard |
Tšebeliso | Motsoako o sebetsang oa Pharmaceutical (API);Lefu la Anti-Parkinson |
Optical Rotation [EP]
Qhala bongata bo lekanang le 0.200g ya ntho e dreied le 5g ya hexamethylenetetramine R ho 10ml ya 1mol/L hydrochloric acid mme o hlapolle ho 25.oml ka asiti e tshwanang.Lumella tharollo hore e eme e sirelelitsoe leseli bakeng sa 3h.Lehlakore la ho potoloha ha optical ke -1.27 ° ho -1.34 °
Ponahalo ea Tharollo
Tlosa 1.0g ho 1mol/L hydrochloric acid mme o hlapolle ho 25ml ka solvnet e tšoanang.Tharollo ha e na 'mala o matla ho feta tharollo ea BY6.
Lintho tse Amanang [EP]
Hlahloba ka chromatography ea lera le tšesaane, u sebelisa selulose bakeng sa chromatography R joalo ka ntho ea ho roala.
Tharollo ea teko-Hlakola 0.1g ea ntho e lokelang ho hlahlojoa ka 5ml ea anhydrous formic acid R le ho hlapolla ho 10ml ka methanol R. Lokisetsa hang-hang pele o sebelisoa.
Tharollo ea litšupiso (a) - Hlakola 0.5ml ea tharollo ea teko ho 100ml ka methanol R.
Reference solution (b) - Hlakola 30mg ea tyrosine R ka 1ml ea anhydrous formic acid R 'me u hlapolle ho 100ml ka methanol R. Kopanya 1ml ea tharollo ena le 1ml ea tharollo ea teko.
Etsa kopo ka thoko ho poleiti e le lihlopha tse bolelele ba 20mm, 1oμl ea tharollo ea teko, 10μl ea tharollo ea litšupiso (a) le 20μl ea tharollo ea litšupiso (b).Omella moyeng.Hlahisa ka tsela ea 15cm ho sebelisa motsoako oa 50 volume butanol R, 25 volumes ea glacial acetic acid R le 25 volume ea metsi.Omisa poleiti moeeng o futhumetseng 'me u fafatse ka motsoako o sa tsoa lokisoa oa tekanyo e lekanang ea 10 lekholong m / v tharollo ea ferric chloride R le 5% m / v tharollo ea postassium ferricyanide R. Hlahloba li-chromatoframs hang-hang.Sebaka sefe kapa sefe sa chromatogram se fumanoeng ka tharollo ea tlhahlobo, ntle le sebaka sa mantlha, ha se matla ho feta sebaka se ho chromatogram se fumanoeng ka tharollo ea (a) e bonts'ang.Teko ha e sebetse ntle le haeba chromatogram e fumanoeng ka tharollo ea litšupiso (b) e bonts'a, ka holim'a sebaka se seholo, sebaka se ikhethang se matla ho feta sebaka se ho chromatogram se fumanoeng ka tharollo ea litšupiso (a).
UV Spectrum [EP]
Disslove 30.0mg ho 0.1mol/L hydrochloric acid mme o hlapolle ho 100.oml ka asiti e tšoanang.Hlakola 10.0ml ea tharollo ena ho 100.0ml ka 0.1mol/L hydrochloric acid.Ha e hlahlojoa pakeng tsa 230nm le 350nm, tharollo e bontša tekanyo e le 'ngoe ea ho monya ho 280nm.Monyetla o khethehileng ka bongata bona ke 137 ho isa ho 147, e baloang ho ipapisitsoe le ntho e omisitsoeng.
Tahlehelo ka ho Omisa
Nka sehlahisoa sena, se omeletseng ho boima bo sa feleng ho 105 ° C, ho lahleheloa ke boima ha hoa lokela ho feta 1.0% (Molao o akaretsang 0831).
Residue on Ignition (Sulfated)
Nka l.0g ea Levodopa 'me u e hlahlobe ho ea ka molao (Molao o akaretsang 0841).Se setseng se setseng ha sea lokela ho feta 0.1%.
Litšepe tse boima
Masala a setseng tlas'a ntho ea ho nka mesaletsa ea ho khantša e ke ke ea e-ba le likarolo tse fetang 10 ho milione ea tšepe e boima ha e hlahlojoa ke molao (Melao-motheo e Akaretsang 0821, Molao oa II).
Tlhahlobo ea pH
0.10g ho 10ml ea H2O e sisinyeha ka metsotso e 15.
Boikemisetso ba litaba
Nka sehlahisoa sena ka 0.lg, boima bo nepahetseng, eketsa anhydrous formic acid 2ml ho qhibiliha, eketsa glacial acetic acid 20ml, sisinya, eketsa crystal violet indicator marotholi a 2, ka perchloric acid titration solution (0.1 mol / L) titration ho tharollo ke botala, mme sephetho sa titration se lokisoa ka tlhahlobo e se nang letho.E 'ngoe le e' ngoe ea 1 ml ea perchloric acid titration solution (0.1 mol / L) e lumellana le 19.72mg ea C9H11N04.
JP17 Mokhoa oa Teko
Levodopa, ha e omisitsoe, ha e na ka tlase ho 98.5% ea Levodopa (C9H11NO4).
Tlhaloso Levodopa e hlaha e le tšoeu kapa e bohlooho bo bosoeu hanyenyane, likristale kapa phofo ea kristale.Ha e na monko.E qhibiliha ka bolokolohi ka formic acid, e qhibiliha hanyane ka metsing, 'me e batla e sa qhibilihe ka har'a ethanol (95).E qhibiliha ka ho hlapolla hydrochloric acid.PH ea tharollo e tletseng ea Levodopa e pakeng tsa 5.0 le 6.5.Sebaka se qhibilihang: hoo e ka bang 275 ℃ (ka ho bola).
Boitsebiso
(1) Ho 5 ml ea tharollo ea Levodopa (1 ho 1000) eketsa 1mL ea ninhydrin TS, 'me u chese metsotso e 3 ka bateng ea metsi: 'mala o pherese oa hlaha.
(2) Ho 2 mL ea tharollo ea Levodopa (1 ho 5000) eketsa 10 mL ea 4-aminoantipyrine TS, 'me u sisinyehe: 'mala o mofubelu o hlaha.
(3) Hlakola 3 mg ea Levodopa ka 0.001 mol / L hydrochloric acid TS ho etsa 100 mL.Etsa qeto ea hore na tharollo ea tharollo e laoloa joang tlas'a Ultravioletvisible Spectrophotometry <2.24>, 'me u bapise sepakapaka le Reference Spectrum: ka bobeli li bonts'a matla a tšoanang a ho monya ka nako e tšoanang.
Absorbance <2.24> E 1%1cm (280 nm): 136-146 (kamora ho omisa, 30 mg, 0.001 mol/L hydrochloric acid TS, 1000 mL).
Optical Rotation <2.49> [a]20D:-11.5° ~-13.0°(kamora ho omisa, 2.5 g, 1 mol/L hydrochloric acid TS, 50 mL, 100 mm).
Bohloeki
(1) Ho hlaka le 'mala oa tharollo-Hlakola 1.0 g ea Levodopa ka 20 mL ea 1 mol / L hydrochloric acid TS: tharollo e hlakile ebile ha e na mebala.
(2) Chloride <1.03>-Hlakola 0.5 g ya Levodopa ka 6 mLof hlapolla nitric acid, mme o kenye metsi ho etsa 50 mL.Etsa tlhahlobo ka ho sebelisa tharollo ena e le tharollo ea teko.Lokisetsa tharollo ea taolo ka 0.30 mL ea 0.01 mol/L hydrochloricacid VS (e seng ho feta 0.021%).
(3) Sulfate <1.14>-Hlakola 0.40 g ya Levodopa ka 1 mL ya dilute hydrochloric acid le 30 ml ya metsi, mme o kenye metsi ho etsa 50 mL.Etsa tlhahlobo ka ho sebelisa tharollo ena e le tharollo ea teko.Lokisetsa tharollo ea taolo ka 0.25 mL ea 0.005 mol/L sulfuric acid VS (e seng ho feta 0.030%).
(4) Heavy Metals <1.07>-Tsoela pele ka 1.0 g ea Levodopa ho ea ka Method 2, 'me u etse tlhahlobo.Lokisetsa tharollo ea taolo ka 2.0 mL ea Standard Lead Solution (eseng ho feta 20 ppm).
(5) Arsenic <1.11> - Hlakola 1.0 g ea Levodopa ka 5 mLof hlapolla hydrochloric acid, 'me u etse tlhahlobo ka tharollo ena e le tharollo ea teko (eseng ho feta 2 ppm).
(6) Lintho tse amanang le tsona-Hlakola 0.10 g ea Levodopa ka 10 mL ea sodium disulfite TS, 'me u sebelise tharollo ena e le mohlala oa tharollo.Pipet 1 mL ea tharollo ea sampole, eketsa sodium disulfite TS ho etsa 25 mL hantle.Pipet 1 mL ea tharollo ena, eketsa sodium disulfite TS ho etsa 20 mL hantle, 'me u sebelise tharollo ena e le tharollo e tloaelehileng.Etsa tlhahlobo ka litharollo tsena joalo ka ha ho laetsoe tlasa Thin-layer Chro-matography<2.03>.Spot 5mL e 'ngoe le e 'ngoe ea tharollo ea sampole le tharollo e tloaelehileng poleiting ea selulose bakeng sa mokhoa o mosesane oa ho roka.Theha poleiti ka motsoako oa 1-butanol, metsi, acetic acid (100) le methanol (10:5:5:1) sebaka se ka bang 10 cm, 'me u omise poleiti ka moea.Motsoako oa "ninhydrin" ka har'a acetone (1 ho 50) ka poleiti le mocheso ka 90 ℃ metsotso e 10: matheba ntle le sebaka se ka sehloohong sa tharollo ea sampole ha a matla ho feta sebaka se tsoang tharollong e tloaelehileng.
Tahlehelo ha o Omisa <2.41> Ha e fete 0.30%(1 g, 105℃,3 lihora).
Masalla a ho Ignition <2.44> Ha a fete 0.1% (1 g).
Assay Beha boima bo nepahetseng ka 0.3 g ea Levodopa, e neng e omisitsoe pele, qhala ka 3 ml ea formic acid, eketsa 80 ml ea acetic acid (100), le titrate <2.50> ka 0.1 mol/L perchloric acid VS ho fihlela 'mala oa tharollo o fetoha. ho tloha ho pherese ho isa ho botala bo boputsoa ho isa ho botala (pontšo: marotholi a 3 a crystalviolet TS).Etsa qeto e se nang letho, 'me u etse tokiso e hlokahalang.
ML ka 'ngoe ea 0.1 mol/L perchloric acid VS=19.72 mg ea C9H11NO4
Lijana le polokelo Lijana-Tight lijana.
Storage-Hang khanya.
Likhoutu tsa Kotsi | Xn | RTECS | AY5600000 |
Lipolelo tsa Kotsi | 22-36/37/38-20/21/22 | F | 10-23 |
Lipolelo tsa Tšireletseho | 26-36-24/25 | TSCA | Ee |
WGK Jeremane | 3 | Khoutu ea HS | 2922509099 |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Khanya le moea. Boloka ka lijaneng tse tiisitsoeng sebakeng sa polokelo se pholileng, se omeletseng le se nang le moea o pholileng hole le lintho tse sa lumellaneng.Sireletsa khanya, moea le mongobo.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
![](https://www.ruifuchemical.com/uploads/23.jpg)
Levodopa (L-DOPA) (CAS 59-92-7) e sebelisoa ho phekola lefu la Parkinson.Levodopa (L-DOPA), sethethefatsi se ka tšeptjoang ka ho fetisisa se sebelisoang ho phekola parkinsonism, se ka nkoa e le mofuta oa phekolo e ncha.Levodopa e sebelisoa haholo bakeng sa phekolo ea mefuta eohle ea parkinsonism ntle le e amanang le phekolo ea lithethefatsi ea antipsychotic.Levodopa ke selelekela sa biochemical sa dopamine.E sebelisetsoa ho phahamisa maemo a dopamine ho neostriatum ea bakuli ba parkinsonian.Dopamine ka boeona ha e tšele mokoallo oa mali-bokong mme ka hona ha e na litlamorao tsa CNS.Leha ho le joalo, Levodopa, e le amino acid, e isoa bokong ka litsamaiso tsa lipalangoang tsa amino acid, moo e fetoloang ho dopamine ka enzyme L-aromatic amino acid decarboxylase.Haeba Levodopa e sebelisoa e le mong, e sebelisoa haholo ke L-aromatic amino acid decarboxylase sebeteng, liphio le pampitšana ea mala.Ho thibela metabolism ena ea peripheral, Levodopa e tsamaisoa hammoho le Carbidopa (Sinemet), e leng peripheral decarboxylase inhibitor.Motsoako oa Levodopa le Carbidopa o theola tekanyetso e hlokahalang ea Levodopa mme o fokotsa litlamorao tse amanang le tsamaiso ea eona.Levodopa e sebelisoa haholo bakeng sa phekolo ea mefuta eohle ea parkinsonism ntle le e amanang le phekolo ea lithethefatsi ea antipsychotic.Leha ho le joalo, ha parkinsonism e ntse e tsoela pele, nako ea melemo e tsoang ho tekanyo e 'ngoe le e' ngoe ea Levodopa e ka khutsufatsa (phello ea ho senya).Bakuli ba ka boela ba e-ba le liphetoho tsa tšohanyetso, tse sa lebelloang pakeng tsa ho tsamaea le ho se sisinyehe (on-off effect).Ka metsotso e seng mekae feela, mokuli ea thabelang ho tsamaea ka tsela e tloaelehileng kapa hoo e batlang e le ka tsela e tloaelehileng a ka ’na a tšoaroa ke lefu la parkinsonism ka tšohanyetso.Matšoao ana a kanna a bakoa ke tsoelo-pele ea lefu lena le tahlehelo ea li-terminals tsa striatal dopamine nerve.
-
Levodopa (L-DOPA) CAS 59-92-7 99.0~100.5% USP B...
-
Cefotiam Hydrochloride CAS 66309-69-1 API USP S...
-
Doxorubicin Hydrochloride CAS 25316-40-9 API US...
-
Enalapril Maleate CAS 76095-16-4 Assay 98.0~102...
-
Guanfacine Hydrochloride Guanfacine HCl CAS 291...
-
Naltrexone Hydrochloride CAS 16676-29-2 API USP...
-
Levetiracetam LEV CAS 102767-28-2 API Feme ea U...
-
Palonosetron Hydrochloride CAS 135729-62-3 Puri...
-
Noscapine Hydrochloride Hydrate CAS 912-60-7 AP...
-
Irinotecan Hydrochloride CAS 100286-90-6 Bohloeki...
-
Ropivacaine Hydrochloride Monohydrate CAS 13211...
-
Tetracaine Hydrochloride CAS 136-47-0 API USP S...
-
Sorafenib Tosylate CAS 475207-59-1 Bohloeki ≥99.0...
-
CAS 274901-16-5 Purity ≥99.0% (HPLC) API
-
Bortezomib CAS 179324-69-7 Bohloeki ≥99.0% (HPLC)...
-
Esmolol Hydrochloride CAS 81161-17-3 Bohloeki ≥99...