LCZ696 Intermediate CAS 1426129-50-1 Bohloeki ≥98.0% (HPLC) ee ≥99.0% Factory High Purity
Phano ea Khoebo LCZ696 (CAS: 936623-90-4) Basehare ba Amanang:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E) -5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S) -ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium letsoai) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Motsoako oa Sacubitril le Valsartan CAS: 936623-90-4
| Lebitso la Lik'hemik'hale | (R)-tert-Butyl (1-([1,1-biphenyl] -4-yl)-3-hydroxypropan-2-yl)carbamate |
| Litlhaloso tse tšoanang | LCZ696 ea mahareng |
| Nomoro ea CAS | 1426129-50-1 |
| Nomoro ea KAtse | RF-PI169 |
| Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
| Foromo ea limolek'hule | C20H25NO3 |
| Boima ba Molek'hule | 327.42 |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| Mokhoa oa Bohloeki / Analysis | ≥98.0% (HPLC) |
| Enantiomeric Feta | hoo: ≥99.0% |
| Mongobo (KF) | ≤1.0% |
| Lintho tse amanang A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl] -4-yl)-2-aminopropan-1-ol |
| Lintho Tse Amanang le B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Lintho Tse Ling | ≤1.0% |
| Litšila ka Kakaretso | ≤2.0% |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Bohareng ba LCZ696 (CAS: 936623-90-4) kalafo ea HFrEF |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Moetsi ea nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Phano ea Khoebo LCZ696 (CAS: 936623-90-4) Basehare ba Amanang:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E) -5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S) -ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium letsoai) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Motsoako oa Sacubitril le Valsartan CAS: 936623-90-4
LCZ696 ke lithethefatsi tsa liteko tse entsoeng ke Novartis Pharmaceutical ea United States bakeng sa phekolo ea bakuli ba nang le Pelo ea ho Faila ka ho fokotsa Ejection Fraction (HFrEF).Ho hloleha ha pelo ke lefu le behang bophelo kotsing.Pelo ea mokuli ha e khone ho pompa mali a lekaneng ho fana ka 'mele,' me a hlaha matšoao a dyspnea, mokhathala le ho boloka metsi butle-butle, ebe butle-butle a eketseha, a ama haholo boleng ba bophelo.LCZ696 e ka ntlafatsa tšireletso ea tlhaho ea 'mele khahlanong le ho hloleha ha pelo, hammoho le ho eketsa boemo ba li-peptide tsa natriuretic le li-peptide tse ling tsa endogenous vasoactive, le ho thibela tsamaiso ea renin-angiotensin-aldosterone (RAAS).LCZ696 e kopantsoe le Novartis's Hypertension Medication (Diovan, lebitso le tloaelehileng: valsartan) le lithethefatsi tsa liteko AHU-377.AHU377 e thibela mochine oa li-peptide tse peli tse ikarabellang ho theola khatello ea mali.Diovan e ntlafatsa vasodilatation le ho susumelletsa 'mele ho ntša sodium le metsi.
