Lenvatinib Mesylate Intermediate CAS 15568-85-1 Bohloeki >97.0% (HPLC) Factory

Tlhaloso e Khutšoanyane:

5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione

CAS: 15568-85-1

Bohloeki: >97.0% (HPLC)

Ponahalo: Phofo e Sehla

Bohareng ba Lenvatinib Mesylate CAS 857890-39-2

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Lenvatinib Mesylate Intermediates Ka Bohloeki bo Phahameng
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione
Litlhaloso tse tšoanang	5-(Methoxymethylene) Meldrum's Acid;Tšilafalo ea Cabozantinib 56;Tšilafalo ea Lenvatinib 79
Nomoro ea CAS	15568-85-1
Nomoro ea KAtse	RF-PI1967
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C8H10O5
Boima ba Molek'hule	186.16
Melting Point	132.0~134.0℃
Botenya	1.297±0.06 g/cm3
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Sehla
1 H NMR Spectrum	E Lumellanang le Sebopeho
Mokhoa oa Bohloeki / Analysis	>97.0% (HPLC)
Litšila ka Kakaretso	<3.00%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Lenvatinib Mesylate (CAS: 857890-39-2)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

5-(Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione (CAS: 15568-85-1) ke bohareng ba Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib ke lithethefatsi tsa kankere ea qoqotho tse entsoeng ke Eisai Corporation ea Japane (Code: E7080), e leng ea inhibitor ea oral multi-receptor tyrosine kinase (RTK) 'me e ka thibela mosebetsi oa kinase oa vascular endothelial growth factor (VEGF) Receptors VEGFR1 ( FLT1), VEGFR2 (KDR), le VEGFR3 (FLT4).Lenvatinib e ka boela ea thibela ho kenya letsoho ha li-RTK tse ling ho pathological angiogenesis, ho hōla ha hlahala, le tsoelo-pele ea kankere ntle le mesebetsi ea bona e tloaelehileng ea lisele tse kenyeletsang fibroblast growth factor (FGF) receptors FGFR1, 2, 3, le 4;platelet-derived growth factor receptor (PDGFR [alpha]), KIT, le RET.[Lipontšo]: Lenvatinib e loketse ho phekola bakuli ba mofetše oa qoqotho oa ho ipheta-pheta kapa mofuta oa metastasis, mofuta oa tsoelo-pele le mofuta o fapaneng oa iodine-refractory.Ka la 13 Hlakola, 2015, US FDA e amohetse sethethefatsi sa anticancer Lenvatinib bakeng sa kalafo ea mofets'e oa qoqotho.Lenvatinib ke inhibitor ea enzyme e nang le lipheo tse ngata, e khonang ho thibela VEGFR2 le VEGFR3 (vascular endothelial growth factor receptor).Lebitso la khoebo la Lenvatinib ke Lenvima.Ka May 20, 2015, European Medicines Agency (EMA) e amohetse Lenvatinib bakeng sa phekolo ea kankere ea qoqotho e hlaselang, e tsoetseng pele kapa ea metastatic (papillary, follicular, Hurthle type) kankere ea qoqotho (DTC).Tekong, nako ea ho phela ha bakuli ba DTC ea radioactive iodine-refractory DTC ba phekoloang ka Lenvatinib e ne e le likhoeli tse 18 ha boleng ba bakuli ba nkang placebo e le likhoeli tse 3 feela.