Lesinurad (RDEA 594) CAS 878672-00-5 Bohloeki >99.5% (HPLC) Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Lesinurad (RDEA 594) (CAS: 878672-00-5) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Lesinurad le Intermediates,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Lesinurad |
| Litlhaloso tse tšoanang | 2- [[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2- [[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio] -Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 878672-00-5 |
| Foromo ea limolek'hule | C17H14BrN3O2S |
| Boima ba Molek'hule | 404.28 g/mol |
| Melting Point | >171℃(Dec.) |
| Botenya | 1.72±0.10 g/cm3 |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu | Phofo e Ntle-Tšweu |
| Boitsebiso | Nako ea ho boloka tlhōrō e kholo ea tharollo ea mohlala e lumellana le tekanyetso ea litšupiso | E lumellana |
| Metsi ka Karl Fischer | <0.50% | 0.14% |
| Masalla a ho Ignition | <0.10% | 0.03% |
| Litšepe tse boima (Pb) | ≤10ppm | <10ppm |
| Lintho tse Amanang (HPLC) | ||
| Tšilafalo e kholo ka ho Fetisisa a le Mong | <0.20% | 0.07% |
| Litšila ka Kakaretso | <1.00% | 0.24% |
| Mokhoa oa Bohloeki / Analysis | >99.5% (HPLC Area) | 99.76% |
| Tlhahlobo | 98.0~102.0% | 99.6% |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Sekhahla sa NMR | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Lesinurad (RDEA 594) (CAS: 878672-00-5) e ile ea amoheloa ke US Food and Drug Administration (FDA) ka December 22, 2015, 'me ea amoheloa ke European Medicines Agency (EMA) ka February 18, 2016. kompone e ile ea ntlafatsoa pejana ke Ardea.AstraZeneca e ile ea fumana k'hamphani ka 2012, eo le eona e ileng ea fumana sehlahisoa.Lebitso la khoebo la moriana ke Zurampic® United States le European Union.Lesinurad ke inhibitor ea pele ea lefats'e e amohelehang ea urate reuptake transporter (URAT1), e kopantsoeng le xanthine oxidase inhibitors ho phekola gout e amanang le hyperuricemia.
Lesinurad, lebitso la khoebo Zurampic.Lesinurad hammoho le xanthine oxidase inhibitor (XOI) bakeng sa hyperuricemic gout syndrome.Mokhoa oa eona oa ts'ebetso ke ho thusa liphio ho ntša uric acid, 'me e sebetsa ka ho thibela mosebetsi oa lipalangoang tse amehang ho khutlisetsa uric acid liphio.
Lesinurad e thibela ts'ebetso ea lipalangoang tsa uric acid (IC50 = 3.36 μM) ea hURAT1 (URAT1 ea motho), e leng makhetlo a fetang 20 phello ea ho thibela ho rURAT1 (rat URAT1) (IC50 = 74.84 μM).Lesinurad e thibela hURAT1 ka ho sebelisana ha masala a bohlokoa a amino acid Phe365.
