Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Lopinavir

CAS: 192725-17-0

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Tekolo (HPLC): 98.0%~102.0%

Khetho ea Peptidomimetic HIV-1 Protease Inhibitor

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Phepelo ea Moetsi e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Lopinavir
CAS: 192725-17-0
E Matla Haholo, e Khethang Peptidomimetic HIV-1 Protease Inhibitor
Sehlahisoa sa Lipatlisiso se Amanang le COVID-19
API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Lopinavir
Litlhaloso tse tšoanang	LPV;ABT-378;Kaletra
Nomoro ea CAS	192725-17-0
Nomoro ea KAtse	RF-API73
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C37H48N4O5
Boima ba Molek'hule	628.81
Polokelo ea Nako e telele	Boloka Nako e telele ho 2-8 ℃
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e tšoeu
Solubility	E qhibiliha ka bolokolohi ho Methanol le Ethanol, E qhibiliha ka 2-Propanol
Boitsebiso ba IR	Sekhahla sa ho monya sa infrared sa sampole ea teko se lumellana le spectrum of reference standard.
Boitsebiso ba HPLC	Nako ea ho boloka sampole ea teko e tsamaisana le ea maemo a referense
Litaba tsa Metsi (ka KF)	≤4.0%
Specific Optical Rotation	-22.0 ° ho -26.0 °
Masalla a ho Ignition	≤0.20%
Litšepe tse boima	≤20ppm
Melting Point	124.0 ho isa ho 127.0 ℃
Molora oa Sulfate	≤0.20%
Residual Solvent (Ethanol)	≤0.50%
Lintho Tse Amanang	(HPLC, Area%)
Ho se hloeke 1
Tšilafalo B (RRT=0.07)	≤0.20%
Tšilafalo ea I (RRT=1.10)	≤0.20%
Tšilafalo E 'ngoe	≤0.10%
Ho se hloeke 2	Tšilafalo efe kapa efe ea Motho ka Botho ≤0.10%
Kakaretso ea Litšila ho Tsoa Mokhoa oa 1 le oa 2	≤0.70%
Litšila ka Kakaretso	≤1.0%
Assay (ka HPLC)	98.0%~102.0%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Selectionive Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Related Research Product

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Lopinavir (ABT-378) ke inhibitor e matla haholo, e khethang ea peptidomimetic ea HIV-1 protease, e nang le Kis ea 1.3 ho isa ho 3.6 pM bakeng sa mofuta oa hlaha le HIV protease e fetotsoeng.Lopinavir e sebetsa ka ho thibela kholo ea HIV-1 ka tsela eo e thibela ts'oaetso ea eona.Lopinavir hape ke SARS-CoV 3CLpro inhibitor e nang le IC50 ea 14.2 μM.Lopinavir ke antiretroviral ea sehlopha sa protease inhibitor.Thibelo ea HIV-1 protease e thibela ho petsoha ha viral polyprotein precursor mme e fella ka ho lokolloa ha li-virion tse sa pheleng, tse se nang tšoaetso.Ke karolo ea motsoako oa phekolo ea HIV/AIDS.Lopinavir, HIV protease inhibitor ea botšelela sehlopheng sa "navir", e thakhotsoe ka kopanelo le ritonavir, e 'ngoe ea HIV protease inhibitor e seng e rekisitsoe (Abbott, 1996);tlhahiso ena ea pele e ile ea hlahisoa e le Kaletra bakeng sa ho sebelisoa hammoho le nucleoside kapa non-nucleoside reverse transcriptase inhibitors bakeng sa phekolo ea AIDS ho batho ba baholo le bana.Lopinavir ke motsoako oa peptidomimetic o nang le motheo oa sebopeho o ts'oanang le oa ritonavir, moo lihlopha tsa ho qetela, haholo-holo valine e fetotsoeng, li ileng tsa hlahisoa ka mekhoa ea ho kopanya peptide.Lopinavir ke inhibitor e matla ea tlholisano ea HIV-I protease e bonts'ang bokhoni bo phahameng khahlano le liphetoho tse hananang le ritonavir.Mefuteng e mengata ea liphoofolo, lithuto tsa pharmacokinetic le mokhatlo oa lopinavirlritonavir li bonts'itse hore thepa e itekanetseng ea lopinavir e ntlafalitse haholo boteng ba ritonavir, ho latela Cmax le nako ea ketso.