Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity
Phepelo ea Moetsi e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Lopinavir
CAS: 192725-17-0
E Matla Haholo, e Khethang Peptidomimetic HIV-1 Protease Inhibitor
Sehlahisoa sa Lipatlisiso se Amanang le COVID-19
API Boleng bo Phahameng, Tlhahiso ea Khoebo
Lebitso la Lik'hemik'hale | Lopinavir |
Litlhaloso tse tšoanang | LPV;ABT-378;Kaletra |
Nomoro ea CAS | 192725-17-0 |
Nomoro ea KAtse | RF-API73 |
Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
Foromo ea limolek'hule | C37H48N4O5 |
Boima ba Molek'hule | 628.81 |
Polokelo ea Nako e telele | Boloka Nako e telele ho 2-8 ℃ |
Brand | Ruifu Chemical |
Ntho | Litlhaloso |
Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
Solubility | E qhibiliha ka bolokolohi ho Methanol le Ethanol, E qhibiliha ka 2-Propanol |
Boitsebiso ba IR | Sekhahla sa ho monya sa infrared sa sampole ea teko se lumellana le spectrum of reference standard. |
Boitsebiso ba HPLC | Nako ea ho boloka sampole ea teko e tsamaisana le ea maemo a referense |
Litaba tsa Metsi (ka KF) | ≤4.0% |
Specific Optical Rotation | -22.0 ° ho -26.0 ° |
Masalla a ho Ignition | ≤0.20% |
Litšepe tse boima | ≤20ppm |
Melting Point | 124.0 ho isa ho 127.0 ℃ |
Molora oa Sulfate | ≤0.20% |
Residual Solvent (Ethanol) | ≤0.50% |
Lintho Tse Amanang | (HPLC, Area%) |
Ho se hloeke 1 | |
Tšilafalo B (RRT=0.07) | ≤0.20% |
Tšilafalo ea I (RRT=1.10) | ≤0.20% |
Tšilafalo E 'ngoe | ≤0.10% |
Ho se hloeke 2 | Tšilafalo efe kapa efe ea Motho ka Botho ≤0.10% |
Kakaretso ea Litšila ho Tsoa Mokhoa oa 1 le oa 2 | ≤0.70% |
Litšila ka Kakaretso | ≤1.0% |
Assay (ka HPLC) | 98.0%~102.0% |
Tekanyetso ea Teko | Maemo a Khoebo |
Tšebeliso | Selectionive Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Related Research Product |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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Lopinavir (ABT-378) ke inhibitor e matla haholo, e khethang ea peptidomimetic ea HIV-1 protease, e nang le Kis ea 1.3 ho isa ho 3.6 pM bakeng sa mofuta oa hlaha le HIV protease e fetotsoeng.Lopinavir e sebetsa ka ho thibela kholo ea HIV-1 ka tsela eo e thibela ts'oaetso ea eona.Lopinavir hape ke SARS-CoV 3CLpro inhibitor e nang le IC50 ea 14.2 μM.Lopinavir ke antiretroviral ea sehlopha sa protease inhibitor.Thibelo ea HIV-1 protease e thibela ho petsoha ha viral polyprotein precursor mme e fella ka ho lokolloa ha li-virion tse sa pheleng, tse se nang tšoaetso.Ke karolo ea motsoako oa phekolo ea HIV/AIDS.Lopinavir, HIV protease inhibitor ea botšelela sehlopheng sa "navir", e thakhotsoe ka kopanelo le ritonavir, e 'ngoe ea HIV protease inhibitor e seng e rekisitsoe (Abbott, 1996);tlhahiso ena ea pele e ile ea hlahisoa e le Kaletra bakeng sa ho sebelisoa hammoho le nucleoside kapa non-nucleoside reverse transcriptase inhibitors bakeng sa phekolo ea AIDS ho batho ba baholo le bana.Lopinavir ke motsoako oa peptidomimetic o nang le motheo oa sebopeho o ts'oanang le oa ritonavir, moo lihlopha tsa ho qetela, haholo-holo valine e fetotsoeng, li ileng tsa hlahisoa ka mekhoa ea ho kopanya peptide.Lopinavir ke inhibitor e matla ea tlholisano ea HIV-I protease e bonts'ang bokhoni bo phahameng khahlano le liphetoho tse hananang le ritonavir.Mefuteng e mengata ea liphoofolo, lithuto tsa pharmacokinetic le mokhatlo oa lopinavirlritonavir li bonts'itse hore thepa e itekanetseng ea lopinavir e ntlafalitse haholo boteng ba ritonavir, ho latela Cmax le nako ea ketso.
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