Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Purity
Fana ka Losartan Potassium le Li-intermediate tse Amanang le Boleng bo Phahameng
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Lebitso la Lik'hemik'hale | Losartan potasiamo |
| Litlhaloso tse tšoanang | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Letsoai |
| Nomoro ea CAS | 124750-99-8 |
| Nomoro ea KAtse | RF-API98 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | Setšoantšo sa C22H22ClKN6O |
| Boima ba Molek'hule | 461.01 |
| Melting Point | 263.0~265.0℃ |
| Solubility | E qhibiliha ka Bolokolohi ka Metsing le ka Methanol, e Hanyenyane Hanyenyane ka Acetonitrile. |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu |
| Boitsebiso A | Ho Monya ha Infrared: Ho Lokela ho Tšoanang le Maemo a Reference |
| Boitsebiso B | Ho monya ha ultraviolet: Ho tlameha ho tšoana le Reference Standard |
| Teko bakeng sa Potassium | E tlameha ho ba Positive |
| Litaba tsa Metsi (KF) | ≤0.50% |
| Litšepe tse boima | ≤10ppm |
| Lintho tse Amanang (HPLC) | |
| Tšilafalo efe kapa efe ea Motho ka Mong | ≤0.20% |
| Litšila ka Kakaretso | ≤0.50% |
| Residual Solvents (GC) | |
| Cyclohexane | ≤0.10% |
| Joala ba Isopropyl | ≤0.20% |
| Mokhoa oa ho hlahloba / oa ho hlahloba | 98.5 ~ 101.0% (HPLC, e baloang ka anhydrous, motheo o se nang solvent) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Boholo ba Karolo | 90% Ka tlase ho 38 Microns |
| Shelf Life | Likhoeli tse 24 |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | API, Angiotensin II Receptor Antagonist Antihypertensive |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Losartan Potassium ke mohanyetsi oa pele ea matla le ea khethang ea se nang peptide angiotensin II receptor mofuta oa 1 (AT1) ea hlahisoang 'marakeng e le antihypertensive ea molomo hang ka letsatsi.Khatello e thibelang 50% ea ho tlama ha angiotensin II (IC50) ke 20 nM.Losartan (40 μM) e ama ISC empa e thibela phello ea ANGII ho ISC.Losartan e fokotsa haholo ho ata ha lisele tsa Ang II ka har'a lisele tsa mofetše oa endometrial.Motsoako oa losartan le anti-miR-155 o na le phello e matla haholo ea antiproliferative ha e bapisoa le moriana o mong le o mong feela.E entsoe ka metabolite ho hlahisa 5-carboxylic acid metabolite (EXP3174) mme ho tlalehoa hore e theola khatello ea mali.Hajoale e ntse e etsoa lipatlisiso e le pheko e ka bang teng bakeng sa COVID-19 bakeng sa bokhoni ba eona ba ho fokotsa kapa mohlomong ho fokotsa matšoao a COVID-19.
1. Bakeng sa ho phekola khatello ea kelello ea bohlokoa, e ka sebelisoa e le mong kapa e kopane le lithethefatsi tse ling tsa antihypertensive (tse kang diuretics).2. Bakeng sa phekolo ea ho hloleha ha pelo, e ka sebelisoa e le mong kapa hammoho le lithethefatsi tsa cardiotonic kapa diuretic Chemicalbook.3. Ho thibela ho otloa ke lefu ho bakuli ba nang le khatello ea mali le hypertrophy ea ventricular e letšehali.4. E sebelisoa ho liehisa tsoelo-pele ea nephropathy ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le amanang le nephropathy le khatello ea mali.
