Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Methyl (S) -2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

CAS: 328086-60-8

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Bohareng ba PF-07321332 Paxlovid (CAS 2628280-40-8) le Boceprevir (CAS 394730-60-0)

Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Commercial Supply PF-07321332 Paxlovid Li-Intermediate tse Amanang le Boleng bo Phahameng
L-tert-Leucine (H-Tle-OH) CAS 20859-02-3
Caronic Anhydride CAS 67911-21-1
(1R,2S,5S) -6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Methyl (S) -2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Litlhaloso tse tšoanang	Methyl (S) -2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS,3S) -α--[(tert-Butyloxycarbonyl)aMino] -2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate
Nomoro ea CAS	328086-60-8
Nomoro ea KAtse	RF-PI317
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C13H22N2O5
Boima ba Molek'hule	286.33
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e tšoeu
Boitsebiso A	IR: E Tšoanang le Tšebeliso ea Lintho
Boitsebiso B	Nako ea ho Boloka: E Ts'oana le Ntho ea Tšebeliso
Tahlehelo ka ho Omisa	≤1.0%
Masalla a ho Ignition	≤0.20%
Tšilafalo e le Mong	≤0.50%
Litšila ka Kakaretso	≤2.0%
Litšepe tse boima (Pb)	≤20ppm
Bohloeki	≥98.0%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba PF-07321332 Paxlovid (CAS 2628280-40-8) le Boceprevir (CAS 394730-60-0)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) ke bohareng ba PF-07321332 Paxlovid (CAS 2628280-40 -8) le Boceprevir (CAS 394730-60-0).PF-07321332, karolo ea bohlokoa ea Paxlovid (PF-07321332 le Ritonavir) eo e leng mokhethoa oa antiviral oa COVID-19, ke inhibitor e fumanehang ka molomo ea 3C-like protease (3CLPRO) e nang le litlamorao tse matla tsa antiviral khahlano le vaerase ea SARS-CoV-2. le COVID-19.Ka la 6 Nove 2021, Pfizer o phatlalalitse hore Paxlovid o fokolitse ho kena sepetlele le lefu haholo, ho ipapisitsoe le tlhahlobo ea nakoana ea Phase 2/3 EPIC-HR (Avaluation of Protease Inhibition for COVID-19 in High-Risk Patients) thuto e sa boneng habeli. ea bakuli ba seng ba kena sepetlele ba nang le COVID-19, ba kotsing e kholo ea ho fetela ho bokuli bo matla.Boceprevir (EBP-520) ke HCV protease inhibitor (Ki=14 nM) bakeng sa phekolo ea tšoaetso ea kokoana-hloko ea hepatitis C.Boceprevir e nang le pegylated interferon le ribavirin (PegIFN/RBV) e nolofalelitse ntlafatso ea litekanyetso tse tsitsitseng tsa karabelo ea virological ea bakuli ba nang le genotype 1 HCV.Boceprevir e sebelisana le immunosuppressive therapy (IT) ka ho thibela cytochrome P450 3A enzyme.