N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Bohloeki: >99.0% (HPLC)

Ponahalo: Phofo e Bosehla bo Khanyang ho isa ho bosehla

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Litlhaloso tse tšoanang	N-(3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Nomoro ea CAS	162012-67-1
Nomoro ea KAtse	RF-PI2026
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C14H7ClF2N4O2
Boima ba Molek'hule	336.68
Kutloisiso	Ha e Mamelle Moeeng, Ha e Mamele Mocheso
Melting Point	242.0~244.0℃
Ntlha e belang	489℃
Botenya	1.616
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Bosehla bo Khanyang ho isa ho Phofo e Sehla
Mokhoa oa Bohloeki / Analysis	>99.0% (HPLC)
Tahlehelo ka ho Omisa	<0.50%
Masalla a ho Ignition	<0.20%
Lintho Tse Amanang
Tšilafalo ea Motho ka Mong	<0.50%
Litšila ka Kakaretso	<1.00%
Litšepe tse boima	≤20ppm
Infrared Spectrum	E Ikamahanya le Sebopeho
Proton NMR Spectrum	E Ikamahanya le Sebopeho
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) ke karolo e bohareng ea motsoako oa Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate ke mofuta oa letsoai oa Afatinib.Afatinib ke moloko oa bobeli, o tsamaisoang ka molomo, inhibitor e ke keng ea fetoloa ea lelapa la ErbB la tyrosine kinases.Mechanism of ActionAfatinib e theola pontšo ea ErbB ka ho tlama ka mokhoa o ts'oanelang ho lihlopha tsa kinase tsa epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 le HER4, e leng se etsang hore ho be le thibelo e ke keng ea qojoa ea tyrosine kinase autophosphorylation;e boetse e thibela transphosphorylation ea HER3.Afatinib e amoheloa e le monotherapy bakeng sa phekolo ea EGFR tyrosine kinase inhibitor (TKI) - batho ba baholo ba sa tsebeng letho ba nang le sebaka se tsoetseng pele kapa DefinitionChEBI: Letsoai la maleate le fumanoang ka ho kopanya afatinib le likarolo tse peli tsa molar tsa maleic acid.E sebelisoa bakeng sa kalafo ea pele ea bakuli ba nang le mofetše oa matšoafo oa metastatic o seng o monyane.