N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Boleng bo Phahameng
Fana ka Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la Lik'hemik'hale: N (4) -Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
Metabolite e sebetsang ea Molnupiravir, e ts'episang COVID-19 inhibitor
| Lebitso la Lik'hemik'hale | N(4) -Hydroxycytidine |
| Litlhaloso tse tšoanang | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Nomoro ea CAS | 3258-02-4 |
| Nomoro ea KAtse | RF-PI309 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lik'hilograma |
| Foromo ea limolek'hule | C9H13N3O6 |
| Boima ba Molek'hule | 259.22 |
| Melting Point | 169.0 ~ 172.0 ℃ |
| Solubility | E qhibiliha ho 100 mM ho DMSO le ho 50 mm ka Metsing |
| Botenya | 1.93±0.1 g/cm3 |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| NMR | E tsamaellanang le Sebopeho |
| Mokhoa oa Bohloeki / Analysis | >98% (HPLC) |
| Tahlehelo ka ho Omisa | ≤1.0% |
| Tšilafalo e le Mong | ≤0.50% |
| Litšepe tse boima | ≤20ppm |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Metabolite e sebetsang ea Molnupiravir (EIDD-2801), e thibelang COVID-19. |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
N.EIDD-1931 (NHC) e na le ts'ebetso e pharalletseng ea antiviral khahlano le li-coronavirus tse ngata, ho kenyeletsoa SARS-CoV-2, MERS-CoV, SARS-CoV, le sehlopha se amanang le zoonotic 2b kapa 2c Bat-CoVs ka karolelano ea IC50 ea 0.15 μM, hammoho le e eketsehile potency khahlano le coronavirus e nang le liphetoho tsa khanyetso ho nucleoside analog inhibitor remdesivir.Ho litoeba tse tšoaelitsoeng ke SARS-CoV kapa MERS-CoV, tsamaiso ea prophylactic le ea phekolo ea Molnupiravir (EIDD-2801), NHC-prodrug e fumanehang ka molomo (β-D-N4-hydroxycytidine-5'-isopropyl ester), e ntlafetseng ea mosebetsi oa matšoafo. , le ho fokotsa titer ea kokoana-hloko le tahlehelo ea boima ba 'mele.Ho fokotseha ha lihlahisoa tsa MERS-CoV in vitro le in vivo li ne li amahanngoa le ho eketseha ha phetoho ea phetoho ea phetoho ho kokoana-hloko empa e se cell cell RNA, e tšehetsang mokhoa oa ho bolaea mutagenesis ho CoV.Matla a NHC/EIDD-2801 khahlano le li-coronavirus tse ngata le bioavailability ea molomo e totobatsa ts'ebeliso ea eona e ka bang teng e le antiviral e sebetsang khahlano le SARS-CoV-2 le li-zoonotic coronavirus tse ling tse tlang.
