Paclitaxel (Taxol) CAS 33069-62-4 Assay (HPLC) 97.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Paclitaxel (Taxol) (CAS: 33069-62-4) ka boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Paclitaxel (Taxol),Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Paclitaxel |
| Litlhaloso tse tšoanang | Taxol;Abraxane;Genaxol;Genetaxyl;OncoGel;Pacliex;(-) -Paclitaxel |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 33069-62-4 |
| Foromo ea limolek'hule | C47H51NO14 |
| Boima ba Molek'hule | 853.92 g/mol |
| Melting Point | 211℃(Dec.) |
| Botenya | 0.200 |
| Ho qhibiliha ha Metsi | Ha e qhibilihe ka Metsing |
| Solubility | E qhibiliha ha bonolo ka Chloroform, Acetone le Litlhapi tse ling tsa Organic. |
| Botsitso | E tsitsitseng.Ha e tsamaellane le li-Agent tse Matla tsa Oxidizing.E tukang. |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | Phofo e Tšoeu ea Crystalline, e sa nkheng | E lumellana |
| Boitsebiso (A) | IR: E lumellana le RS | E lumellana |
| Boitsebiso (B) | HPLC: RT Concordant le RS | E lumellana |
| Phetoho e khethehileng | -49.0 ° ho -55.0 ° | -52.3° |
| Metsi ka Karl Fischer | ≤4.00% | 0.91% |
| Masalla a ho Ignition | ≤0.20% | 0.02% |
| Litšepe tse boima (Pb) | ≤20ppm | <20ppm |
| Metsoako e Amanang | ||
| Kakaretso | ≤2.00% | 0.11% |
| 10-Deacetylbaccatin III | ≤0.10% | Ha e fumanwe |
| Baccatin III | ≤0.20% | Ha e fumanwe |
| Fotodegradant | ≤0.10% | Ha e fumanwe |
| 10-Deacetylpaclitaxel | ≤0.50% | 0.04% |
| 2-Debenzoylpaclitaxel-2-Pentenoate | ≤0.70% | Ha e fumanwe |
| 7-Epipaclitaxel | ≤0.40% | 0.014% |
| 10,13-Bissidechainpaclitaxel | ≤0.50% | 0.022% |
| 7-Acetylpaclitaxel | ≤0.60% | Ha e fumanwe |
| 13-Tes-baccatin III | ≤0.10% | 0.004% |
| 7-Tes-Paclitaxel | ≤0.30% | Ha e fumanwe |
| Litšila tse ling tsa Motho ka Mong | ≤0.10% | E lumellana |
| 0ganic Litšila tse Fetohang | E lumellana | |
| Hexan | ≤290ppm | 31ppm |
| Aceton | ≤5000ppm | 1210ppm |
| Assay (HPLC) | 97.0 ~ 102.0% (e baloa ka mokhoa oa anhydrous, o se nang solvent) | 99.88% |
| Liteko tsa Moeli oa Likokoana-hloko | ||
| Kakaretso ea Aerobic Microbial Count | ≤100 cfu/g | <100 cfu/g |
| Staphylococcus Aureus | Ho ba sieo | Ho ba sieo |
| Salmonella | Ho ba sieo | Ho ba sieo |
| Escherichia Coli | Ho ba sieo | Ho ba sieo |
| Likokoana-hloko tsa Endotoxins | ≤0.4EU/mg | <0.4EU/mg |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le USP43 Paclitaxel | |
Sephutheloana:Botlolo ea Fluorinated, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Paclitaxel
C47H51NO14 853.91
Benzenepropanoic acid, -(benzoylamino) --hydroxy-, 6,12b-bis(acetyloxy) -12-(benzoyloxy) -2a,3,4,4a,5,6,9,10,11,12,12a,12b -dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2a,4,4a,6,9(R*,S*),11,12,12a,12b]]-.
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS) -1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6, 9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]-benz[1,2-b]oxet-5-one 6, 12b-diacetate, 12-benzoate, 9-ester e nang le (2R,3S) -N-benzoyl-3-phenylisoserine [33069-62-4].
Paclitaxel ha e na karolo e ka tlase ho karolo ea 97.0 mme e seng ho feta karolo ea 102.0 lekholong ea C47H51NO14, e baloang ka mokhoa oa anhydrous, o se nang solvent.
[Tlhokomeliso-Paclitaxel ke cytotoxic.Tlhokomelo e kholo e lokela ho nkoa ho thibela ho hema likaroloana tsa Paclitaxel le ho pepesa letlalo ho eona.]
Packaging le ho boloka-Ho boloka lijaneng tse thata, tse sa keneleng khanya, 'me u boloke mocheso o laoloang oa kamore.
Labeling-The labeling e bonts'a mofuta oa ts'ebetso e sebelisoang ho hlahisa thepa le tlhahlobo ea metsoako e Amanang eo thepa e lumellanang le eona.
USP Reference standards <11>-
USP Endotoxin RS
USP Paclitaxel RS Tobetsa ho Sheba Sebopeho
USP Paclitaxel Related Compound A RS
Cephalomannine.
USP Paclitaxel Related Compound B RS
10-Deacetyl-7-Epipaclitaxel.
USP Paclitaxel Impurity Mixture RS
Motsoako oa Paclitaxel le metsoako e latelang e amanang le eona: propyl analog, cephalomannine, sec-butyl analog, n-butyl analog, benzyl analog, baccatin VI, pentyl analog, le 7-epipaclitaxel.
Boitsebiso-
A: Infrared Absorption <197K>.
B: Nako ea ho boloka tlhoro e kholo ea chromatogram ea boitokisetso ba Assay e lumellana le e ho chromatogram ea Tokisetso e Tloaelehileng, joalo ka ha e fumanoe ho Assay.
Potoloho e khethehileng 781S: pakeng tsa 49.0 le 55.0 ho 20, e baloang ka anhydrous, motheo o se nang solvent.
Tharollo ea teko: 10 mg ka mL, ka methanol.
Liteko tsa palo ea likokoana-hloko <61> le Liteko bakeng sa likokoana-hloko tse boletsoeng <62>-Palo eohle ea palo ea likokoana-hloko tsa aerobic ha e fete 100 cfu ka g.E finyella litlhoko tsa liteko tsa ho ba sieo ha Staphylococcus aureus, Pseudomonas aeruginosa, mefuta ea Salmonella, le Escherichia coli.
Li-endotoxins tsa baktheria 85-Ha e na ho feta 0.4 USP Endotoxin Unit ka mg ea paclitaxel.
Metsi, Method Ic <921>: eseng ho feta 4.0%.
Masala a ho khantša <281>: eseng ho feta 0.2%.
Litšepe tse boima, Mokhoa oa II <231>: 0,002%.
Metsoako e Amanang-
teko 1 (bakeng sa thepa e ngotsoeng e le e arohaneng le mehloli ea tlhaho) -Haeba thepa e lumellana le teko ena, ho ngoloa ho bontša hore e kopana le Test 1 ea metsoako e amanang le USP.
Diluent-Lokisetsa joalokaha ho laetsoe ho Assay.
Tharollo A-Lokisetsa acetonitrile e tlhotliloeng le e senyehileng.
Tharollo B-Lokisetsa metsi a tlhotliloeng le a khaotsoeng.
Mobile phase-Sebelisa metsoako e feto-fetohang ea Tharollo A le Tharollo B joalokaha e laetsoe bakeng sa tsamaiso ea Chromatographic.Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Tharollo ea ho tšoaneleha ha Sisteme-Hlakola litekanyo tse lekantsoeng ka nepo tsa USP Paclitaxel Related Compound A RS le USP Paclitaxel Related Compound B RS ka methanol ho fumana tharollo e nang le likhakanyo tse ka bang 10 µg tsa e 'ngoe le e 'ngoe ea mL.Fetisetsa 5.0 mL ea tharollo ena ho botlolo ea volumetric ea 50-mL, hlapolla ka Diluent ho ea holimo, 'me u kopanye.
Tlhōlo e tloaelehileng-Hlakola, ka thuso ea sonication, tekanyo e lekantsoeng ka nepo ea USP Paclitaxel RS ho Diluent, 'me u hlapolle ka bongata, le ka mokhoa oa mohato ha ho hlokahala, ka Diluent ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 5 µg ka mL.
Tharollo ea teko-Sebelisa ho lokisetsa Assay.
Chromatographic system (bona Chromatography <621>) -Mokelikeli oa chromatograph o na le mochine oa 227-nm le kholomo ea 4.6-mm × 25-cm e nang le 5-µm packing L43.Sekhahla sa phallo ke hoo e ka bang 2.6 mL ka motsotso.Mocheso oa kholomo o bolokiloe ho 30. Chromatograph e hlophisitsoe ka tsela e latelang.
Nako (metsotso) Tharollo A (%) Tharollo B (%) Elution
0–35 35 65 ea boikemelo
35–60 35®80 65®20 lekhalo la mola
60–70 80®35 20®65 mothapo o lekanang
70–80 35 65 isocraticChromatograph the System suitability solution, le ho tlaleha likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: linako tse lekanyelitsoeng tsa ho boloka li ka bang 0.78 bakeng sa motsoako o amanang le paclitaxel A le 0.86 bakeng sa motsoako o amanang le paclitaxel B (e amanang le nako ea ho boloka paclitaxel e fumanoeng ho tsoa tharollo ea Tlhahlobo);'me qeto, R, pakeng tsa motsoako o amanang le paclitaxel A le motsoako oa B o amanang le paclitaxel ha o ka tlase ho 1.0.Chromatograph the Standard solution, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: kheloha e lekanyelitsoeng bakeng sa liente tse kopitsoang ha e fete 2.0%.
Ts'ebetso-Enta molumo (hoo e ka bang 15 µL) ea tharollo ea Teko ka har'a chromatograph, rekota chromatogram, 'me u lekanye libaka tsa litlhoro tse kholo.Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Paclitaxel e nkiloeng ke foromo:
100(Labohlano / rU)
moo F e leng karolo ea karabo e amanang le tlhoro e 'ngoe le e 'ngoe ea litšila (sheba Lethathamo la 1 bakeng sa litekanyetso);ri ke sebaka se phahameng sa ho se hloeke ha motho ka mong;'me rU ke sebaka se phahameng sa paclitaxel.
Lethathamo la 1
Nako e Batlang ea ho Boloka Nako e Lelaneng ea Karabo (F) Moeli oa Lebitso (%)
0.24 1.29 Baccatin III 0.2
0.53 1.00 10-Deacetylpaclitaxel 0.5
0.57 1.00 7-Xylosylpaclitaxel 0.2
0.78 1.26 Cephalomannine (Paclitaxel e amanang le motsoako A) a11
0.78 1.26 2'',3''-Dihydrocephalomanine a21
0.86 1.00 10-Deacetyl-7-epipaclitaxel (Motsoako o amanang le Paclitaxel B) 0.5
1.10 1.00 Benzyl analoge3 b12
1.10 1.00 3'',4''-Dehydropaclitaxel C b22
1.40 1.00 7-Epicephalomanine 0.3
1.85 1.00 7-Epipaclitaxel 0.5
1 Qeto e ka 'na ea se ke ea phethahala bakeng sa litlhōrō tsena, ho itšetlehile ka lichelete tse lekanyelitsoeng tse teng;kakaretso ea a1 le a2 ha e fete 0.5%.
2 Qeto e ka 'na ea se ke ea phethahala bakeng sa litlhōrō tsena, ho itšetlehile ka lichelete tse lekanyelitsoeng tse teng;kakaretso ea b1 le b2 ha e fete 0.5%.
3 Lebitso le latelang la lik'hemik'hale le abeloa motsoako o amanang, benzyl analog:Baccatin III 13-ester e nang le (2R,3S) -2-hydroxy-3-phenyl-3- (2-phenylacetylamino) propanoic acid.
Ntle le ho se fetele meeli ea litšila tse amanang le paclitaxel ho Lethathamo la 1, ha ho na ho feta 0.1% ea litšila tse ling tse fumanoang;mme ha se fete 2.0% ya ditshila kaofela tse fumanwang.
teko 2 (bakeng sa lintho tse ngotsoeng e le tse hlahisoang ke mokhoa oa semisynthetic)— Haeba boitsebiso bo lumellana le tlhahlobo ena, ho ngoloa ho bontša hore ho kopana le Test 2 ea metsoako e amanang le USP.
Diluent - Sebelisa acetonitrile.
Tharollo A-Sebelisa motsoako o sefiloeng le o khaotsoeng oa metsi le acetonitrile (3:2).
Tharollo B-Sebelisa acetonitrile e tlhotliloeng le e senyehileng.
Mobile phase-Sebelisa metsoako e feto-fetohang ea Tharollo A le Tharollo B joalokaha e laetsoe bakeng sa tsamaiso ea Chromatographic.Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Sisteme suitability solution-Hlakola ka nepo boima bekha bo bongata ba USP Paclitaxel RS le USP Paclitaxel Related Compound B RS in Diluent, shaking and sonicating ha ho hlokahala, ho fumana tharollo e nang le li-concentrations tse tsejoang tse ka bang 0.96 mg le 0.008 mg ka mL, ka ho latellana.
Tharollo ea teko-Fetisetsa hoo e ka bang 10 mg ea Paclitaxel, e lekantsoeng ka nepo, ho botlolo ea volumetric ea 10-mL, qhibiliha le ho hlapolla ka Diluent ho volume, ho sisinyeha le sonicating ha ho hlokahala, 'me u kopanye.
Chromatographic system (sheba Chromatography 621)— Mokelikeli oa chromatograph o na le mochine oa 227-nm le kholomo ea 4.6-mm × 15-cm e nang le 3-µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1.2 mL ka motsotso.Mocheso oa kholomo o bolokiloe ho 35. Chromatograph e hlophisitsoeng ka tsela e latelang.
Nako (metsotso) Tharollo A (%) Tharollo B (%) Elution
0-20 100 0 isocratic
20-60 100®10 0®90 mothapo o lekanang
60-62 10®100 90®0 lekhalo la mola
62-70 100 0 isocraticChromatograph tharollo ea ts'ebetso ea Sistimi, 'me u tlalehe likarabo tsa tlhōrō joalokaha li laetsoe bakeng sa Tsamaiso: linako tse lekanyelitsoeng tsa ho boloka li ka bang 0.94 bakeng sa motsoako o amanang le paclitaxel B le 1.0 bakeng sa paclitaxel;qeto, R, pakeng tsa motsoako o amanang le paclitaxel B le paclitaxel ha o ka tlase ho 1.2;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 2.0%.
Ts'ebetso-Ka karohano kenya li-volume tse lekanang (hoo e ka bang 15 µL) ea Diluent le Tharollo ea Teko ka har'a chromatograph, rekota li-chromatogram, 'me u lekanye libaka tsa litlhoro tsohle.Hlokomoloha litlhoro life kapa life ka lebaka la Diluent.Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Paclitaxel e nkiloeng ke foromo:
100(Labohlano / rs)
moo F e leng lebaka la karabelo le lekanyelitsoeng bakeng sa ho se hloeke ka leng (sheba Lethathamo la 2 bakeng sa litekanyetso);ri ke sebaka se phahameng sa ho se hloeke ka 'ngoe se fumanoang ho tsoa Tharollong ea Tlhahlobo;'me rs ke kakaretso ea libaka tsa litlhōrō tsohle tse fumanoang ho tsoa Tharollong ea Tlhahlobo.
Lethathamo la 2
Nako e Batlang ea ho Boloka Nako e Lelaneng ea Karabo (F) Moeli oa Lebitso (%)
0.11 1.24 10-Deacetylbaccatin III 0.1
0.20 1.29 Baccatin III 0.2
0.42 1.39 Photodegradant2 0.1
0.47 1.00 10-Deacetylpaclitaxel 0.5
0.80 1.00 2-Debenzoylpaclitaxel-2-pentenoate 0.7
0.921 1.00 reng ea Oxetane e ile ea buloa, acetyl le benzoyl tsa falla2 x1
0.921 1.00 10-Acetoacetylpaclitaxel x2
0.941 1.00 10-Deacetyl-7-epipaclitaxel (Motsoako o amanang le Paclitaxel B) x3
1.37 1.00 7-Epipaclitaxel 0.4
1.45 1.00 10,13-Bissidechainpaclitaxel2 0.5
1.54 1.00 7-Acetylpaclitaxel 0.6
1.80 1.75 13-Tes-baccatin III 0.1
2.14 1.00 7-Tes-paclitaxel 0.3
1 Qeto e ka 'na ea se ke ea phethahala bakeng sa litlhōrō tsena, ho itšetlehile ka lichelete tse lekanyelitsoeng tse teng;kakaretso ea x1, x2, le x3 ha e fete 0.4%.
2 Mabitso a latelang a lik'hemik'hale a abetsoe metsoako e amanang le Photodegradant;reng ea Oxetane ea buloa, acetyl le benzoyl tsa falla;le 10,13-Bissidechainpaclitaxel:
Fotodegradant
(1R,2R,4S,5S,7R,10S,11R,12S,13S,15S,16S)-2,10-diacetyloxy-5,13-dihydroxy-4,16,17,17-tetramethyl-8-oxa- 3-oxo-12-phenylcarbonyloxypentacyclo[11.3.1.01,11.04,11.07,10]heptadec-15-yl
(2R,3S) -2-hydroxy-3-phenyl-3-(phenylcarbonylamino)propanoate
Lesale la Oxetane le ile la buloa, acetyl le benzoyl tsa falla
(1S,2S,3R,4S,5S,7S,8S,10R,13S)-5,10-diacetyloxy-1,2,4,7-tetrahydroxy-8,12,15,15-tetramethyl-9-oxo- 4-(phenylcarbonyloxymethyl)tricyclo[9.3.1.03,8]pentadec-11-en-13-yl
(2R,3S) -2-hydroxy-3-phenyl-3-(phenylcarbonylamino)propanoate
10,13-Bissidechainpaclitaxel
Baccatin III 13-ester with (2R,3S) -2-hydroxy-3-phenyl-3-(phenylcarbonylamino)propanoic acid, 10-ester with (2S,3S) -2-hydroxy-3-phenyl-3-(phenylcarbonylamino "Propanoic acid".
Ntle le ho se fetele meeli ea litšila tse amanang le paclitaxel ho Lethathamo la 2, ha ho na ho feta 0.1% ea litšila tse ling tse fumanoang;mme ha se fete 2.0% ya ditshila kaofela tse fumanwang.
teko 3 (bakeng sa lintho tse ngotsoeng e le tse hlahisoang ke mokhoa oa ho belisoa ha sele ea semela)— Haeba thepa e lumellana le teko ena, ho ngoloa ho bontša hore e kopana le Test 3 ea metsoako e amanang le USP.
Tharollo A-Lokisetsa motsoako o sefiloeng le o sentsoeng oa metsi le acetonitrile (3: 2).
Tharollo B-Lokisetsa acetonitrile e tlhotliloeng le e senyehileng.
Mobile phase-Sebelisa metsoako e feto-fetohang ea Tharollo A le Tharollo B joalokaha e laetsoe bakeng sa tsamaiso ea Chromatographic.Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Sistimi e loketseng tharollo-Hlakola USP Paclitaxel Impurity Mixture RS ka acetonitrile, sonicating ha ho hlokahala, ho fumana tharollo e nang le mahloriso a tsebahalang a ka bang 1 mg ka mL.
Tharollo e tloaelehileng-Hlakola palo e lekantsoeng ka nepo ea USP Paclitaxel RS ka acetonitrile, ho etsa sonicating ha ho hlokahala, ho fumana tharollo e nang le mahloriso a tsebahalang a ka bang 1 mg ka mL.
Tharollo ea teko-Fetisetsa hoo e ka bang 10 mg ea Paclitaxel, e lekantsoeng ka nepo, ho botlolo ea volumetric ea 10-mL.Qhala ka hare le ho hlapolla ka acetonitrile ho bophahamo ba modumo, sonicating ha ho hlokahala, 'me kopanya.
Chromatographic system (sheba Chromatography 621)— Mokelikeli oa chromatograph o na le mochine oa 227-nm le kholomo ea 4.6-mm × 15-cm e nang le 3-µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1.2 mL ka motsotso.Chromatograph e hlophisitsoe ka tsela e latelang.
Nako (metsotso) Tharollo A (%) Tharollo B (%) Elution
0-28 100 0 isocratic
28-33 100®98 0®2 lekhalo la mola
33–58 98®10 2®90 mothapo o mothalo
58-60 10 90 isocratic
60-63 10®100 90®0 mothapo o lekanang
63-70 100 0 isocraticChromatograph Tharollo ea ho tšoaneleha ha Sisteme, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: qeto, R, lipakeng tsa paclitaxel le analoge ea benzyl ha e tlase ho 1.8.Chromatograph the Standard solution, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: kheloha e lekanyelitsoeng bakeng sa liente tse kopitsoang ha e fete 2.0%.[temoso-Bakeng sa ho tsebahatsa sehlohlolong, nako e lekantsoeng ea ho bolokoa e fanoe ho Lethathamo la 3. Linako tse lekanyelitsoeng tsa ho boloka li lekantsoe le Paclitaxel.]
Lethathamo la 3
Relative Retention Time Limit (%)
Analog ea Propyl1 0.54 0.2
Cephalomannine (Paclitaxel e amanang le motsoako A) 0.76 0.5
sec-Butyl analog2 0.81 0.2
n-Butyl analoge3 0.89 0.1
Benzyl analoge 1.10 0.4
Baccatin VI 1.23 0.2
Analog ea pentyl4 1.31 0.2
7-Epipaclitaxel 1.51 0.4
1 Lebitso le latelang la lik'hemik'hale le abeloa motsoako o amanang le propyl analog:Baccatin III 13-ester e nang le (2R,3S) -3-butanoylamino-2-hydroxy-3-phenylpropanoic acid.
2 Lebitso le latelang la lik'hemik'hale le abeloa motsoako o amanang le sec-Butyl analog:Baccatin III 13-ester le (2R,3S) -2-hydroxy-3- (2-methylbutanoylamino) -3-phenylpropanoic acid.
3 Lebitso le latelang la lik'hemik'hale le abeloa motsoako o amanang le n-Butyl analoge:Baccatin III 13-ester le (2S,3S) -2-hydroxy-3-(pentanoylamino) -3-phenylpropanoic acid.
4 Lebitso le latelang la lik'hemik'hale le abeloa motsoako o amanang le Pentyl analog:Baccatin III 13-ester le (2R,3S) -3-(hexanoylamino) -2-hydroxy-3-phenylpropanoic acid.
Ts'ebetso-Enta molumo (hoo e ka bang 12 µL) ea tharollo ea Teko ka har'a chromatograph, rekota chromatogram, 'me u lekanye libaka tsa litlhoro tsohle.Bala liperesente tsa ho se hloeke ka 'ngoe karolong ea Paclitaxel e nkiloeng ke foromo:
100(ri / rU)
moo ri leng karabelo ea ho se hloeke ha motho ka mong;'me rU ke kakaretso ea libaka tsa litlhōrō tsohle tse fumanoang ho tsoa Tharollong ea Tlhahlobo.Ntle le ho se fetele meeli ea litšila tse amanang le paclitaxel ho Lethathamo la 3, ha ho na ho feta 0.1% ea litšila tse ling tse fumanoang;mme ha se fete 2.0% ya ditshila kaofela tse fumanwang.
Tlhahlobo-
Diluent-Lokisetsa motsoako oa methanol le acetic acid (200:1).
Mobile phase-Lokisetsa motsoako o tlhotliloeng le o senyehileng oa metsi le acetonitrile (11:9).Etsa litokiso ha ho hlokahala (sheba Tšebeliso ea Sistimi tlas'a Chromatography 621).
Tloaelo ea ho itokisa-Hlakola, ho sebelisa sonication ha ho hlokahala, tekanyo e nepahetseng e lekantsoeng ea USP Paclitaxel RS ka Diluent, 'me u hlapolle ka bongata,' me u hatelle ha ho hlokahala, ka Diluent ho fumana tharollo e nang le motsoako o tsejoang oa hoo e ka bang 1 mg ka mL.
Boitokisetso ba tlhahlobo-Fetisetsa hoo e ka bang 10 mg ea Paclitaxel, e lekantsoeng hantle, ho botlolo ea volumetric ea 10-mL.Qhala ka Diluent, u sebelisa sonication ha ho hlokahala, hlapolla ka Diluent ho bophahamo ba modumo, 'me u kopanye.
Chromatographic system (bona Chromatography <621>) -Mokelikeli oa chromatograph o na le mochine oa 227-nm le kholomo ea 4.6-mm × 25-cm e nang le 5-µm packing L43.Sekhahla sa phallo ke hoo e ka bang 1.5 mL ka motsotso.Chromatograph ea Boitokisetso ba Maemo, 'me u tlalehe likarabelo tse phahameng joalo ka ha li laetsoe bakeng sa Tsamaiso: ntlha ea mohatla e pakeng tsa 0.7 le 1.3;'me kheloha e lekanyelitsoeng bakeng sa liente tse ikatisang ha e fete 1.5%.
Ts'ebetso-Ka karohano kenya li-volume tse lekanang (tse ka bang 10 µL) tsa Tokisetso e Tloaelehileng le boitokisetso ba Assay ho chromatograph, rekota li-chromatogram, 'me u lekanye libaka tsa litlhoro tse kholo.Bala palo, ka mg, ea C47H51NO14 karolong ea Paclitaxel e nkiloeng ka foromo:
10C(rU / rS)
moo C e leng mahloriso, ka mg ka mL, ea USP Paclitaxel RS ka ho lokisetsa Standard;'me rU le rS ke likarabelo tse phahameng ka ho fetisisa bakeng sa paclitaxel tse fumanoeng ho tloha boitokisetsong ba Assay le ho lokisetsa Standard, ka ho latellana.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Matshwao a Kotsi Xn - A Kotsi
Likhoutu tsa Kotsi R37/38 - Ho halefisa tsamaiso ea ho hema le letlalo.
R41 - Kotsi ya tshenyo e kgolo mahlong
R42/43 - E ka baka maikutlo ka ho hema le ho ama letlalo.
R62 - Kotsi e ka bang teng ya thari e senyehileng
R68 - Kotsi e ka bang teng ea litlamorao tse ke keng tsa etsolloa
R40 - Bopaki bo fokolang ba phello ea carcinogenic
R48 - Kotsi ya tshenyo e kgolo bophelong bo botle ka ho pepesehela nako e telele
R20/21/22 - E kotsi ka ho hema, ho kopana le letlalo le haeba e koetsoe.
R68/20/21/22 -
Tlhaloso ea Tšireletseho S22 - U se ke ua hema lerōle.
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
S36/37/39 - Apara liaparo tse loketseng tse sireletsang, liatlana le tšireletso ea mahlo / sefahleho.
S45 - Ha ho ka etsahala kotsi kapa ha o ikutlwa o sa phele hantle, batla keletso ho ngaka hanghang (bontsha leibole neng kapa neng ha ho kgoneha.)
Li-ID tsa UN 1544
WGK Jeremane 3
RTECS DA8340700
FLUKA BRAND F DIKHOUTU 10-21
HS Code 2932999021
Sehlopha sa Likotsi 6.1(b)
Sehlopha sa ho paka III
Chefo LD50 intraperitoneal toeba: 128mg/kg
Paclitaxel (Taxol) (CAS: 33069-62-4), sehlahisoa sa tlhaho se arohaneng le makhapetla a Pacific yew, se sebetsa hantle ho phekola kankere ea mahe a bomme ea refractory.Ho fapana le lisebelisoa tse ling tsa antineoplastic, paclitaxel e bonahala e na le mekhoa e 'maloa ea ts'ebetso, ho kenyelletsa le ketso ea antimicrotubule ka ho khothaletsa polymerization ea tubulin le ho tsitsisa ha li-microtubules, ka hona, ho emisa mitosis le ho khothalletsa lefu la lisele.Phepelo ea paclitaxel e lekantsoe ke bongata ba eona bo tlase ba tlhaho 'me hajoale e ntse e etsoa ka tsela ea semi-synthetic ho tloha deacetylbaccatin Ⅲ e arohaneng le linale tsa sefate sa yew.Ho phetheloa ha morao tjena ha li-syntheses tse peli tsa taxol ho hlotse ho rarahana ha sebopeho sa motsoako oa sehlooho mme ho ka ba molemo ho fumana li-analogue tse amanang haufi-ufi, tseo tse ling tsa tsona li fumanoeng li na le tšebetso ea antitumor.Paclitaxel e na le ts'ebeliso e ka bang teng kalafong ea mofetše oa matsoele oa metastatic, mofets'e oa matšoafo, mofetše oa hlooho le molala, le melanoma e mpe.
Metsoako e chefo e makaleng le makhasi a Taxus chinensis e ile ea aroloa ka 1856 'me ea bitsoa "taxine," e ileng ea tsejoa e le mofuta oa motsoako oa alkaloid e tšoeu.Hajoale, har'a lithethefatsi tsohle tsa antitumor, thekiso ea paclitaxel e fetoha ea pele lefats'eng e le sethethefatsi se tsebahalang sa mofets'e se nang le ts'ebetso e matla e pharalletseng.Ka October 1995, Chaena e ile ea e-ba naha ea bobeli e nang le tlhahiso ea molao ea paclitaxel le ente ea eona lefatšeng.Katleho e ile ea fumanoa tlas'a boiteko bo sa khaotseng ba bafuputsi Setsing sa Materia Medica, Sekolo sa Machaena sa Bongaka sa Bongaka.
Paclitaxel (CAS: 33069-62-4) ke antineoplastic e neng e sebelisoa ho phekola bakuli ba nang le kankere ea matšoafo, mahe a bomme, kankere ea matsoele, hlooho le molala, le mefuta e tsoetseng pele ea Kaposi's sarcoma.Paclitaxel ke mitotic inhibitor e sebelisoang ho chemotherapy ea mofetše.E boetse e sebelisoa thutong ea sebopeho le ts'ebetso ea li-microtuble ho tubulin.
Paclitaxel e na le phello e ntle ho mofetše oa mahe a bomme le mofets'e oa matsoele o hanyetsanang le lithethefatsi joalo ka mofets'e oa mahe a bomme le platinum, le tebello e ntle ea kalafo ea mofets'e oa tšoelesa ea senya, mofets'e oa hlooho le molala, mofets'e oa 'metso, hlahala ea kokoana-hloko, mofets'e oa endometrial, lymphoma, kankere ea senya, kankere ea karolo e ka holimo ea tšilo ea lijo, lisele tse nyenyane le kankere ea matšoafo ea sele e seng nyenyane.
Paclitaxel (Taxol) (CAS: 33069-62-4) ke motsoako o rarahaneng haholo, o arohaneng le makhapetla a sefate sa yew sa Pacific.E tlama li-tubulin dimers le microtubulin filaments, e khothalletsang kopano ea likhoele le ho thibela ho senyeha ha tsona.Keketseho ena ea botsitso ba li-microfilaments e fella ka ho sitisoa ha mitosis le cytotoxicity le ho senya mesebetsi e meng e tloaelehileng ea microtubular, joalo ka lipalangoang tsa axonal meleng ea methapo.Mokhoa o ka sehloohong oa ho hanyetsa o fumanoeng bakeng sa paclitaxel ke ho tsamaisoa ka ntle ho lisele tsa tumor, e leng se lebisang ho fokotseng ho bokellana ha lithethefatsi ka hare ho lisele.Mofuta ona oa ho hanyetsa o kopane le P-glycoprotein e tsamaisang lithethefatsi tse ngata.
E ka ba le kutloelo-bohloko ha nako e telele e le maemong a mongobo.
