Palonosetron Hydrochloride CAS 135729-62-3 Purity >99.0% (HPLC) (T) API Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Palonosetron Hydrochloride

CAS: 135729-62-3

Ponahalo: Phofo ea Crystalline e tšoeu kapa e sa Tšoeu

Bohloeki: >99.0% (HPLC) (T)

Palonosetron Hydrochloride ke mohanyetsi ea matla haholo, ea khethang le ea sebetsang ka molomo oa 5-HT3 receptor antagonist e sebelisoang ho thibela le ho phekola ho nyekeloa ke pelo le ho hlatsa ho bakoang ke chemotherapy (CINV).Antiemetic.

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Phepelo ea Khoebo Palonosetron Hydrochloride le Li-intermediate tse Amanang:
(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R) -1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S) -3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Palonosetron Hydrochloride
Litlhaloso tse tšoanang	Palonosetron HCl;(S,S)-Palonosetron Hydrochloride;RS-25259;RS25259 197;(S) -2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-Hexahydro-1H-Benzo[de]isoquinolin-1-one Hydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-Hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride ;Aloxi;Onicit
Nomoro ea CAS	135729-62-3
Nomoro ea KAtse	RF-API03
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C19H24N2O·HCl
Boima ba Molek'hule	332.87
Boemo bo Lokelang ho Qoba	Mocheso o Mamela
Melting Point	307℃ (Dec.)
Sollubility ka Metsing	E qhibiliha ka ho Feletseng ka Metsing
Solubility	Ha Hanyane Hanyenyane ka Ethanol
Mocheso oa ho Romela	Ambient Mocheso
COA & MSDS	E fumaneha
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu kapa e sa Tšoeu
Palonosetron Hydrochloride	>99.0% (HPLC) (T)
Potoloho e Khethehileng [α]20/D	-98.0°～-104.0°
Boitsebiso	Eketsa BiI7K4, Hlahisa Pula ea Orange Yellow
Boitsebiso	TLC e Tsamaellana le Ntho ea Reference
Boitsebiso	IR e tsamaellana le Standard IR
Boitsebiso	Ho khetholla e le Chloride
Solubility	E qhibiliha ka bolokolohi metsing, ha e qhibilihe hanyenyane ka Methanol, e qhibiliha hanyenyane haholo ka har'a ethanol, e sa qhibiliheng ka har'a acetone.
Ho hlaka le Mmala oa Tharollo	Max.Yellow No. 2 E Tloaelehileng ea Mmala Tharollo
Boemo ba pH	4.5~6.5 (10mg/ml)
Lintho Tse Amanang
Related Compound A (NO)	<0.10%
Related Compound B (Ene-NO)	<0.10%
Motsoako o amanang le C (S,R)	<0.10%
Motsoako o amanang le D (R,S)	<0.50%
Palonosetron Enantiomer	<0.10%
Related Compound E (3-Ene)	<0.50%
Tšilafalo e le 'Ngoe e sa Boleloeng	<0.10%
Metsoako e setseng
Ethanol	<3000ppm
Tetrahydrofuran	<5000ppm
DMF	<880ppm
Hexane e tloaelehileng	<290ppm
Joala ba Methyl	<3000ppm
Isopropanol	<5000ppm
Methylbenzene	<890ppm
Metsi	<0.30%
Masalla a ho Ignition	<0.20%
Tahlehelo ka ho Omisa	<1.00%
Litšepe tse boima	<10ppm
Tekanyetso ea Teko	United States Pharmacopoeia (USP);Pharmacopoeia ea Europe (EP)
Tšebeliso	Palonosetron Hydrochloride API;5-HT3 Mohanyetsi;CINV

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Moqomo oa Cardboard, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Palonosetron Hydrochloride (CAS: 135729-62-3) ke lithethefatsi tse thibelang ho nyekeloa ke pelo le ho hlatsa, e leng mofuta o mocha o khethang haholo, o nang le kamano e phahameng ea 5-HT3 receptor mohanyetsi o ka thibelang ho hlatsa reflex center peripheral neurons presynaptic 5-HT.Thabo ea moamoheli e ama ka kotloloho tsamaiso ea methapo e bohareng ho 5-HT.Thabo ea receptor ea impulse e hlahisoang ke karolo ea vagal afferent nerve ka mor'a sebaka, ho thibela lipheletsong tsa methapo ea vagus ka maleng, ho thibela lipontšo ho 5-HT.Receptor trigger zone e ka fokotsa sekhahla sa ho nyekeloa ke pelo le ho hlatsa.Bohareng ba bongaka bakeng sa kalafo ea chemotherapy e matla haholo ea emetogenic e bakileng ho nyekeloa ke pelo le ho hlatsa ho lieha.Ka lebaka la phello ea eona e phahameng ea ho folisa, phello e fokolang ea lehlakore, nako e telele ea halofo ea bophelo (hoo e ka bang 40 h), tekanyo e nyane, joalo-joalo, e hohetse tlhokomelo e ngata.

Ka 1,2,3,4-Tetrahydro-1-Naphthoic Acid e le thepa ea ho qala, ho arohana, ho fokotsa, ho fokotsa, cyclization, letsoai la palonosetron hydrochloride granisetron.Liphuputso tsa bongaka li bontšitse hore palonosetron e ka sebelisoa ka mokhoa o sireletsehileng ka corticosteroids, analgesics, antiemetics, antispasmodics le anticholinergic lithethefatsi joaloka lisebelisoa tsa ho qala, ho arohana, ho fokotsa, ho fokotsa, cyclization, letsoai la palonosetron hydrochloride granisetron.