Pazopanib Hydrochloride CAS 635702-64-6 Purity >99.0% (HPLC) API Factory

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Pazopanib Hydrochloride

CAS: 635702-64-6

Ponahalo: Phofo e tšoeu ho isa ho e mosehla hanyenyane

Bohloeki: >99.0% (HPLC)

Tyrosine kinase receptor inhibitor bakeng sa kalafo e tsoetseng pele ea renal cell carcinoma kapa sarcoma e tsoetseng pele ea lisele tse bonolo.

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

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Tlhaloso:

Phepelo ea Moetsi e nang le Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Pazopanib Hydrochloride
CAS: 635702-64-6
Tyrosine kinase receptor inhibitor bakeng sa kalafo e tsoetseng pele ea renal cell carcinoma kapa sarcoma ea lisele tse bonolo tse fumaneng chemotherapy pele.
API Boleng bo Phahameng, Tlhahiso ea Khoebo

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Pazopanib Hydrochloride
Litlhaloso tse tšoanang	Pazopanib HCl;GW786034 HCl;Votrient;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride
Nomoro ea CAS	635702-64-6
Nomoro ea KAtse	RF-API93
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	C21H23N7O2S.ClH
Boima ba Molek'hule	473.987
Solubility	DMSO
Melting Point	300.0~304.0℃
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e mosehla hanyenyane
Boitsebiso	Sekhahla sa ho monya ha infraed sa sampole ea teko se lumellana le se tloaelehileng
Masalla a ho Ignition	≤0.50%
Tšilafalo efe kapa efe ea Motho ka Mong	≤0.30%
Litšila ka Kakaretso	≤1.50%
Litšepe tse boima	≤10ppm
Mokhoa oa Bohloeki / Analysis	≥99.0% (HPLC)
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API, Tyrosine kinase receptor inhibitor

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Pazopanib Hydrochloride (CAS 635702-64-6) ke multi-tyrosine kinase inhibitor ea vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR) -α le - β, fibroblast growth factor receptor (FGFR) -1 le -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), lymphocyte-specific protein tyrosine kinase (Lck), le transmembrane glycoprotein receptor tyrosine kinase (cFms).In vitro, pazopanib e ile ea thibela ligand-induced autophosphorylation ea VEGFR-2, Kit, le PDGFR-beta receptors.Ka vivo, pazopanib e ile ea thibela phosphorylation ea VEGF-induced VEGFR-2 matšoafong a mouse, angiogenesis ka mohlala oa mouse, le kholo ea batho ba bang ba hlahala xenografts ho litoeba.E amohetsoe bakeng sa renal cell carcinoma ke Tsamaiso ea Lijo le Lithethefatsi ea US ka 2009 mme e rekisoa tlasa lebitso la khoebo Votrient ke moetsi oa moriana, GlaxoSmithKline.Votrient ke kinase inhibitor e bontšitsoeng bakeng sa phekolo ea bakuli ba nang le: 1) e tsoetseng pele ea renal cell carcinoma.2) sarcoma ea lisele tse bonolo tse tsoetseng pele tse fumaneng chemotherapy ea pele.