Paxlovid Boceprevir Intermediate CAS 565456-77-1 Assay ≥99.0%

Tlhaloso e Khutšoanyane:

Lebitso: (1R,2S,5S) -6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride

CAS: 565456-77-1

Ponahalo: Phofo e tšoeu ho isa ho e tšoeu

Tekanyo: ≥99.0%

Bohareng ba PF-07321332 Paxlovid (CAS 2628280-40-8) le Boceprevir (CAS 394730-60-0)

Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Commercial Supply PF-07321332 Paxlovid Li-Intermediate tse Amanang le Boleng bo Phahameng
L-tert-Leucine (H-Tle-OH) CAS 20859-02-3
Caronic Anhydride CAS 67911-21-1
(1R,2S,5S) -6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	(1R,2S,5S) -6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride
Litlhaloso tse tšoanang	Methyl (1R,2S,5S) -6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate Hydrochloride
Nomoro ea CAS	565456-77-1
Nomoro ea KAtse	RF-PI318
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C9H15NO2.ClH
Boima ba Molek'hule	205.683
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu ho isa ho e tšoeu
Boitsebiso A	IR: E Tšoanang le Tšebeliso ea Lintho
Boitsebiso B	Nako ea ho Boloka: E Ts'oana le Ntho ea Tšebeliso
Enantiomer	≤0.15%
Related Impurity (ka HPLC)
Tšilafalo e sa Tsejoeng	≤0.20%
Litšila ka Kakaretso	≤1.0%
Metsi	≤0.50%
Masalla a ho Ignition	≤0.10%
Litšepe tse boima	≤20ppm
Tlhahlobo	≥99.0%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba PF-07321332 Paxlovid (CAS 2628280-40-8) le Boceprevir (CAS 394730-60-0)

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

(1R,2S,5S) -6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride (CAS 565456-77-1) ke motsoako oa azabicyclohexane o sebelisoang ha ho lokisoa lefu la sebete la C. kokoana-hloko (HCV) NS3 serine protease inhibitor.Ke lipakeng tsa PF-07321332 Paxlovid (CAS 2628280-40-8) le Boceprevir (CAS 394730-60-0).PF-07321332 ke inhibitor e matla le e sebetsang ka molomo ea SARS-CoV 3C-like protease (3CLPRO) .PF-07321332 e shebane le vaerase ea SARS-CoV-2 mme e ka sebelisoa bakeng sa lipatlisiso tsa COVID-19.Boceprevir (INN, trade name Victrelis) ke protease inhibitor e sebelisoang e le phekolo ea hepatitis C genotype 1. E tlama sebakeng se sebetsang sa HCV nonstructural 3 NS3 (HCV).E ne e ntse e ntlafatsoa ke Schering-Plough, empa hona joale e ntse e ntlafatsoa ke Merck ho tloha ha Schering e fumanoa ka 2009. E ile ea amoheloa ke FDA ka May 13, 2011.