Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa ea Polymyxin B Sulfate (CAS: 1405-20-5) e nang le boleng bo phahameng.Re ka fana ka COA, phano ea lefats'e ka bophara, tse nyane le tse ngata tse fumanehang.Haeba u thahasella Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Polymyxin B Sulfate |
| Litlhaloso tse tšoanang | Polymyxin B Sulfate Letsoai;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Boemo ba Setoko | Ka Setokong, Bokhoni ba Tlhahiso Lithane tse 10 ka Selemo |
| Nomoro ea CAS | 1405-20-5 |
| Foromo ea limolek'hule | C55H96N16O13·2H2SO4 |
| Boima ba Molek'hule | 1301.56 |
| Melting Point | 217.0~220.0℃(Dec.) |
| E hloahloa | Hygroscopic.E Mamela Leseli le Mocheso |
| Ho qhibiliha ha Metsi | E qhibiliha ka Metsing, 50 mg/mL.E qhibiliha hanyenyane ka Ethanol |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Brand | Ruifu Chemical |
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | E tšoeu kapa e batla e na le Crystalline Powder | E lumellana |
| Boitsebiso A. Linako tsa ho bolokoa ha litlhōrō tse kholo tse tsoang ho sampuli ea tharollo li lumellana le tsa tharollo e tloaelehileng, joalokaha e fumanoe tekong ea ho hlophisoa ha Polymyxins. | E lumellana | |
| PH (2%) | 5.0~7.0 | 5.7 |
| PH (0.5%) | 5.0~7.5 | 5.5 |
| Molora oa Sulfate | ≤0.75% |
|
| Potoloho e Khethehileng [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd. ka Anh. Substance) | -85.0° |
| Sulfate | 15.5 ~ 17.5% | 16.65% |
| Tahlehelo ka ho Omisa | ≤6.00% | 3.0% |
| Masalla a ho Ignition | ≤0.10% | 0.02% |
| Litšepe tse boima | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0~12.0% | 9.8% |
| Kakaretso ea Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Lintho tse Amanang, HPLC |
|
|
| Tšilafalo ea Motho ka Mong | ≤3.0% | 2.723% |
| Litšila ka Kakaretso | ≤17.0% | 16.223% |
| Assay HPLC (ODB) | Kakaretso ea Polymyxins B1,B2,B3 le B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Assay, Microbiological (joalokaha e le joalo) | ≥6500lU/mg | 8255IU/mg |
| Boholo ba Karolo | ≥99.0% ≤30um ka molumo | E lumellana |
| ≥90.0% ≤25um ka vol | ||
| ≥75.0%≤20um ka molumo | ||
| ≥35.0%≤10um ka molumo | ||
| Qetello | Sehlahisoa se lumellana le USP42 |
|
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Khanya e utloang bohloko.Boloka setshelo se kwetswe ka thata mme o se boloke sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.Ha e lumellane le lisebelisoa tse matla tsa oxidizing.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Matshwao a Kotsi Xn - A Kotsi
Likhoutu tsa Kotsi 22 - E kotsi ha e koetsoe
Tlhaloso ea Tšireletseho S22 - U se ke ua hema lerōle.
S24/25 - Qoba ho kopana le letlalo le mahlo.
Li-ID tsa UN 3249
WGK Jeremane 3
RTECS TR1150000
FLUKA BRAND F CODES 3-8-10
HS Code 2941909099
Sehlopha sa Likotsi 6.1(b)
Sehlopha sa ho paka III
Polymyxin ke sehlopha sa lithibela-mafu tsa polypeptide tse hlahisoang ke Bacillus polymyxa (bacilluspolymyxa).Polymyxin B le E li sebelisetsoa merero ea meriana, 'me li-sulfate tsa tsona li sebelisoa hangata.Sehlahisoa sa antibacterial le tšebeliso ea bongaka ea Polymyxin B Sulfate e tšoana le ea polymyxin E. E na le liphello tse thibelang kapa tsa bactericidal ho bacilli ea gram-negative, e kang Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis le Shigella.
Polymyxin Sulfate B e tšoana le polymyxin e, 'me e na le litlamorao tsa inhibitory kapa bactericidal ho bacilli ea gram-negative, joalo ka e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis le bacilli ea lets'ollo.E sebelisoa haholo-holo ka leqeba, pampiri ea ho ntša metsi, leihlo, tsebe, trachea le likarolo tse ling tsa tšoaetso e bakoang ke Pseudomonas aeruginosa le Pseudomonas tse ling.E ka boela ea sebelisoa bakeng sa sepsis le peritonitis.Le tšoaetso e matla e bakoang ke aminoglycosides, libaktheria tse hanyetsanang le cephalosporin tsa moloko oa boraro, Pseudomonas aeruginosa kapa libaktheria tse ling tse nang le kutloelo-bohloko, tse kang bacteremia, endocarditis, pneumonia, tšoaetso ea ka mor'a ho chesa, joalo-joalo.
1. Ho rotha ka methapo: batho ba baholo le bana ba nang le ts'ebetso e tloaelehileng ea renal 1.5 ~ 2.5mg ka kilogram ea boima ba 'mele (ka kakaretso e seng ho feta 2.5mg ka kilogram ea boima ba' mele) bakeng sa letsatsi la 1, e arotsoe ka makhetlo a 2, rotha hang ka mor'a lihora tsa 12.50mg e 'ngoe le e' ngoe ea sehlahisoa sena e hlapolloa ka 500ml ea 5% ea tharollo ea tsoekere ebe e rotha.Bana ba nang le ts'ebetso e tloaelehileng ea renal ba ka mamella 4mg ka kilogram ea boima ba 'mele bakeng sa letsatsi le le leng.2. Ente ea intramuscular: batho ba baholo le bana: 2.5 ~ 3mg ka kilogram ea boima ba 'mele ka 1st, e fanoeng ka lihlopha, hang ka mor'a lihora tsa 4 ~ 6.Masea a ka fihla ho 4mg ka kilogram ea boima ba 'mele ka letsatsi le masea a sa tsoa tsoaloa a ka fihla ho 4.5mg ka kilogram ea boima ba' mele.3. Intrathecal ente (bakeng sa Pseudomonas aeruginosa meningitis): 5mg ka millilithara ea moriana oa metsi o lokiselitsoeng ka ente ea sodium chloride.Batho ba baholo le bana ba ka holimo ho lilemo tse 2, 5mg letsatsi le leng le le leng, ka mor'a matsatsi a 3-4 a kopo, ba fetoha hang ka letsatsi le leng le le leng, bonyane libeke tse 2, ho fihlela setso sa cerebrospinal fluid e le mpe, 'me tsoekere e tloaelehile.Bakeng sa bana ba ka tlase ho lilemo tse 2, sebelisa 2mg hang ka letsatsi bakeng sa matsatsi a 3-4 a latellanang (kapa 2.5mg hang ka letsatsi le leng le le leng), ebe o sebelisa 2.5mg hang ka letsatsi le leng le le leng ho fihlela tlhahlobo e tloaelehile.4. Lebelo la marotholi a mahlo ke 1 ~ 2.5mg ka ml.
Qoba ho kopana le lithethefatsi tse senyang liphio, li-relaxation tsa mesifa ea skeletal, lithibela-mafu tsa aminoglycoside, li-anesthetics tse nang le liphello tse hlakileng tsa ho phomola ha mesifa (e kang enflurane), joalo-joalo, le quinine, magnesium, joalo-joalo, e ke ke ea sebelisoa ka methapo ka nako e le 'ngoe.Polymyxin B sulfate e kopantsoe le sulfonamides, rifampicin, semi-synthetic penicillin, joalo-joalo, bakeng sa phekolo ea mafu a matla a baktheria a gram-negative a hanyetsanang le lithethefatsi, 'me phello e molemo ho feta ea ts'ebeliso e le' ngoe.
1, Basali ba bakhachane le ba anyesang, bana le bakuli ba nang le bothata bo matla ba renal ba atile haholo.2. Sehlahisoa sena se chefo haholo 'me se na le phello e mpe ea phekolo ho tšoaetso ea lisele tse tebileng.Ha se khetho ea pele bakeng sa tšoaetso efe kapa efe.3. Ho entoa ka methapo ho ka baka khatello ea maikutlo, eo hangata e sa sebelisoeng.Bonyane halofo ea lethal dose ea letsatsi le letsatsi e hloka ho rotha ka methapo, eseng bolus e potlakileng hang-hang, e le ho qoba thibelo e kholo ea neuromuscular.4. Ha ea lokela ho kopanngoa le lithethefatsi tse ling tse nang le nephrotoxicity kapa neuromuscular blockade ho qoba likotsi.
Patlisiso ea biochemical.Polymyxin B ke anti-gram-negative bacilli polypeptide antibiotic, e ka fetolang sebopeho sa lera ho dutla limolek'hule tse nyane le ho thibela kholo ea baktheria ea gram-negative.E na le phello ea bactericidal ho Escherichia coli.Lipid A likaroloana tse hokahaneng le lipopolysaccharides tsa baktheria.Li-pores tse nyane li kenngoa ka har'a lera le ka ntle la lisele tsa letlalo.Mokhoa oa ketso: e tlama le ho kena-kenana le ho kenella ha lera la cytoplasmic.Antibacterial spectrum: Libaktheria tsa gram-negative.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate ke letsoai la sulfate la mofuta oa polymyxin, ntho e hlahisoang ke ho hōla ha Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), kapa motsoako oa matsoai a joalo a mabeli kapa ho feta.E na le matla a seng ka tlase ho 6000 Polymyxin B Units ka mg, e baloang ka motheo o omisitsoeng.
Ho paka le ho boloka-Ho boloka ka har'a lijana tse thata, tse sa keneleng khanya.
Labeling-Moo e phuthetsoeng bakeng sa ho kopanya lengolo la ngaka, lengolo le bolela palo ea Li-Units tsa Polymyxin B ka har'a setshelo le milligram, hore ha e reretsoe ho sebelisoa ho etsa tlhahiso, hore ha e hloeke, le hore matla a eona a ke ke a tiisetsoa nako e telele ho feta 60. matsatsi kamora ho buloa.Moo e reretsoeng ho sebelisoa ha ho etsoa liforomo tsa litekanyetso tse entoang kapa tse hloekisitsoeng, leibole e bolela hore ha e na kotsi kapa e tlameha ho tsoela pele ho sebetsoa nakong ea ho lokisoa ha liforomo tse nang le ente kapa tse ling tse nyopa.
USP Reference standards <11>-
USP Polymyxin B Sulfate RS
Boitsebiso-
A: Teko ea Boitsebiso ba Liquid Chromatographic-
Mobile phase-Lokisetsa motsoako oa 0.1 M tribasic sodium phosphate le acetonitrile (77:23), 'me u lokise le phosphoric acid ho pH ea 3.0.Etsa litokiso ha ho hlokahala (sheba Ho Ikemela ha Sistimi tlas'a Chromatography <621>.
Tharollo e tloaelehileng-Lokisetsa tharollo ea USP Polymyxin B Sulfate RS in Mobile phase e nang le mahloriso a ka bang 3.5 mg ka mL.Sireletsa tharollo ena khanyeng.
Tharollo ea liteko-Lokisetsa tharollo ea Polymyxin B Sulfate in Mobile phase e nang le mahloriso a ka bang 3.5 mg ka mL.Sireletsa tharollo ena khanyeng.
Chromatographic system (sheba Chromatography <621>)-Mokelikeli oa chromatograph o na le mochine oa 212-nm le kholomo ea 4.6-mm × 25-cm e nang le 5-µm packing L1.Sekhahla sa phallo ke hoo e ka bang 1 mL ka motsotso.
Ts'ebetso-Ka karohano kenya meqolo e lekanang (hoo e ka bang 10 µL) ea tharollo e Tloaelehileng le Tharollo ea Teko ka har'a chromatograph, 'me u tlalehe li-chromatogram.Chromatogram e fumanoeng ho tsoa Tharollong ea Teko e lumellana ka boleng le e fumanoeng ho tsoa ho Tharollo e Tloaelehileng, e bontšang tlhōrō e kholo e tsamaellanang le polymyxin B1 le litlhōrō ka nako ea ho boloka nako e ka bang 0.5 (polymyxin B2) le 0.6 (polymyxin B3).
B: Qhala 2 mg ho 5 mL ea metsi, eketsa 5 ml ea 2.5 N sodium hydroxide, kopanya, 'me u kenye marotholi a 5 a cupric sulfate solution (1 ho 100), ho sisinyeha ka mor'a ho eketsoa ha lerotholi le leng le le leng: ho hlahisoa 'mala o mofubelu oa violet. .
C: Tharollo (1 ho 20) e finyella litlhoko tsa liteko tsa Sulfate <191>.
pH <791>: pakeng tsa 5.0 le 7.5, ka tharollo e nang le 5 mg ka mL.
Tahlehelo ha o omisa <731> -Omisa hoo e ka bang 100 mg, e lekantsoeng hantle, ka botlolong ea capillary-stoppered ka vacuum ho 60 ℃ bakeng sa lihora tse 3: ha e lahleheloe ke ho feta 7.0% ea boima ba eona.
Likahare tsa phenylalanine-Fetisetsa hoo e ka bang 0.375 g ea Polymyxin B Sulfate, e lekantsoeng hantle, ho ea ho 100-mL ea volumetric flask, qhibiliha le ho hlapolla ka 0.1 N hydrochloric acid ho bophahamo ba modumo, le ho kopanya.Lekanya mokelikeli oa tharollo ena ka boholo ba hoo e ka bang 264 nm (A264), 258 nm (A258), le 252 nm (A252), le ho kenngoa ha 280 nm (A280) le 300 nm (A300).Bala peresente ea phenylalanine karolong ea Polymyxin B Sulfate e nkiloeng ka foromo:
(9.4787/W) (A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
eo ho eona W e boima, ka g, ea Polymyxin B Sulfate e nkiloeng: e na le pakeng tsa 9% le 12% ea phenylalanine, e baloang ka motheo o omisitsoeng.
Litlhoko tse ling- Haeba bakeng sa ho kopanngoa ha lengolo la ngaka, ho kopana le litlhoko tsa Masalla ha ho chesoa tlas'a Polymyxin B bakeng sa Ente.Moo leibole e bolelang hore Polymyxin B Sulfate ha e hloekile, e kopana le litlhokahalo bakeng sa Liteko tsa Sterility <71> 'me, moo e reretsoeng mefuta ea litekanyetso tse ka entoang, bakeng sa Pyrogen tlas'a Polymyxin B bakeng sa Ente.Moo leibole le bolelang hore Polymyxin B Sulfate e tlameha ho sebetsoa hape nakong ea ho lokisoa ha liforomo tsa litekanyetso tse entoang, e fihlela litlhoko tsa Pyrogen tlasa Polymyxin B bakeng sa Ente.
Assay-Tsoela pele ka Polymyxin B Sulfate joalokaha e laetsoe tlas'a Litlhahlobo tsa Antibiotics-Microbial <81>.
