Pregabalin CAS 148553-50-8 Purity >99.0% (HPLC) Antiepileptic API
Moetsi ea nang le Bohloeki bo Phahameng le Tlhahiso ea Khoebo
Lebitso la lik'hemik'hale: PregabalinCAS: 148553-50-8
Pregabalin ke moriana oa antiepileptic oa moloko oa bobeli (AED)
Lebitso la Lik'hemik'hale | Pregabalin |
Litlhaloso tse tšoanang | (S) -3-(Aminomethyl) -5-Methylhexanoic Acid;PD-144723;PD144723;CI 1008;CI-1008;Lyrica |
Nomoro ea CAS | 148553-50-8 |
Nomoro ea KAtse | RF-API57 |
Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
Foromo ea limolek'hule | C8H17NO2 |
Boima ba Molek'hule | 159.23 |
Melting Point | 194.0 ~ 196.0 ℃ |
Sollubility ka Metsing | Ha e Monyehe ka Metsing |
Solubility | Ha Hanyane Hanyenyane ka Ethanol |
Boemo ba ho Romela | Tlas'a Mocheso oa Ambient |
Brand | Ruifu Chemical |
Ntho | Litlhaloso |
Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu |
Boitsebiso | IR: E Tšoanang le Tšebeliso ea Lintho |
Phetoho e khethehileng | +10.0°~+13.0° (C=1, Metsi) |
Tahlehelo ka ho Omisa | <0.50% |
Molora oa Sulfate | <0.10% |
Lintho Tse Amanang | Tšilafalo A <0.15% |
Litšila tse sa Boleloeng tse Hlahang Pele ho Pregabalin (teko ea A) <0.10% | |
Litšila tse sa Boleloeng tse Eluting Ka mor'a Pregabalin (teko ea B) <0.10% | |
Kakaretso ea teko A le B <0.50% | |
Bohloeki Ka HPLC R-Isomer | <0.15% |
Heavy Metals (as Pb) | <10ppm |
Chlorides (Cl) | <0.05% |
Metsoako e setseng | |
Joala ba Isopropyl | <5000ppm |
Ethyl Acetate | <5000ppm |
Tetrahydrofuran | <250ppm |
Ether ea isopropyl | <500ppm |
Ethanol | <1000ppm |
Mokhoa oa Bohloeki / Analysis | > 99.0% (HPLC ka motheo o omisitsoeng) |
Tekanyetso ea Teko | Maemo a Khoebo |
Tšebeliso | Antiepileptic Drug API |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo
![1](https://a395.goodao.net/uploads/15.jpg)
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Pregabalin ke moloko oa bobeli oa lithethefatsi tsa antiepileptic (AED) tse tsejoang ka lebitso la lebitso la Lyrica (Pfizer, Tadworth) UK le USA, e nang le sebopeho sa γ-amino butyric acid sebopeho sa eona sa molek'hule, se nang le litlamorao tsa anticonvulsant. e atlehile ho ntlafatsoa ke k'hamphani ea Pfizer bakeng sa kalafo ea bohloko ba peripheral neuropathic, kapa kalafo ea adjuvant ea ho ts'oaroa ha karolo e itseng.Pregabalin ke sethethefatsi sa Anticonvulsant le antiepileptic se sebelisetsoang ho phekola lefu la sethoathoa, bohloko ba neuropathic, fibromyalgia, le lefu la ho tšoenyeha ka kakaretso.Tšebeliso ea eona bakeng sa lefu la sethoathoa ke phekolo ea tlatsetso bakeng sa ho tsietsana ka mokhoa o sa fellang kapa ntle le kakaretso ea bobeli ho batho ba baholo.Ka December 2008, US Food and Drug Administration (FDA) e ile ea amohela pregabalin (lebitso la khoebo "Lyrica") bakeng sa phekolo ea lefu la tsoekere la peripheral neuropathic pain (DPN) le postherpetic neuralgia (PHN) e leng Bobeli bohloko bo tloaelehileng ba neuropathic.Pregabalin e na le sesupo se lumelletsoeng mme e sebelisoa haholo bakeng sa kalafo ea lefu la ho tšoenyeha le akaretsang.Liteko tse 'maloa tse sa sebetseng, tse foufetseng habeli, tse laoloang ke placebo li fumane hore pregabalin ke phekolo e sebetsang bakeng sa bakuli ba nang le bothata ba ho tšoenyeha ka kakaretso le lefu la ho tšoenyeha ha sechaba.Lethal dose ea titration Phekolo ea lefu la sethoathoa: 25 mg bd ka matsatsi a 7, e eketsoe ka 50 mg ka matsatsi a 7;tlhokomelo e tloaelehileng 300 mg letsatsi le letsatsi, e arotsoe ka litekanyetso tse 2 kapa tse 3 (max. 600 mg ka letsatsi, e arotsoe ka litekanyetso tse 2 kapa tse 3).Matšoenyeho a tloaelehileng a ho tšoenyeha: 150 mg letsatsi le leng le le leng, e arotsoe ka litekanyetso tsa 2 kapa 3, bakeng sa matsatsi a 7, ho eketsoa ka 150 mg ka matsatsi a 7 (max. 600 mg letsatsi le letsatsi, e arotsoe ka litekanyetso tsa 2 kapa 3).Haeba u emisa pregabalin, ho kgothaletswa ho theola bonyane beke e le 'ngoe ho qoba ho tsoa ka tšohanyetso.Tlhokomeliso Bakuli ba nang le maemo a ka bakang lefu la encephalopathy.Bakuli ba nang le ts'ebetso e matla ea pelo ea congestive.
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