(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst CAS 112022-83-0 Optical Purity ≥98.0%

Phepelo ea Moetsi;Boleng bo Phahameng le Theko ea Tlholisano

Li-Catalysts tsa CBS
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (hoo e ka bang 1mol/L ka Toluene);CAS: 112022-81-8
(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R) -Me-CBS Catalyst (hoo e ka bang 1mol / L ka Toluene);CAS: 112022-83-0

CBS Catalyst
The CBS catalyst kapa Corey-Bakshi-Shibata catalyst ke asymmetric catalyst e nkiloeng ho proline.E fumana litšebeliso tse ngata ho karabelo ea manyolo joalo ka phokotso ea CBS, karabelo ea Diels-Alder le (3+2) cycloadditions.Proline, motsoako oa chiral oa tlhaho, o fumaneha habonolo ebile o theko e tlaase.E fetisetsa stereocenter ea eona ho catalyst eo le eona e khonang ho khanna karabelo ea manyolo ka khetho ho e 'ngoe ea li-enantiomers tse peli tse ka khonehang.Khetho ena e bakoa ke khatello e matla nakong ea phetoho e hlahang bakeng sa enantiomer e le 'ngoe empa eseng bakeng sa e' ngoe.

CBS Catalysts bakeng sa Phokotso ea Asymmetric le Asymmetric Synthesis
CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst e sebelisitsoe ho fokotsa asymmetric ea prochiral ketones.Lisebelisoa tse ling li kenyelletsa motsoako oa enantioselective oa α-hydroxy acid, α-amino acid, C2-symmetrical ferrocenyl diols, le propargyl alcohols.

(R) - (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol / L ka Toluene) CAS: 112022-83-0 e ka sebelisoa e le sesosa sa phokotso ea asymmetric borane ea perfluoroalkyl ketone.Lisebelisoa tse ling li kenyelletsa motsoako oa enantioselective oa α-hydroxy acid, α-amino acid, C2 symmetrical ferrocenyl diols, le propargyl alcohols.E boetse e sebelisoa ka phokotso ea desymmetrizing e lebisang ho (S) -4-hydroxycyclohexenone.E na le thuso tlhahisong ea li-stereospecific motifs tse kang α-hydroxy acids, α-amino acid, symmetrical ferrocenyl diols le propargyl alcohols.

(R) - (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol / L ka Toluene) CAS: 112022-83-0 ke motsoako oa organoboron o sebelisoang ho manyolo a tlhaho.Sehlahisoa sena, se entsoeng ke Itsuno le Elias James Corey, se hlahisoa ke ho futhumatsa (R) - (+) -2- (diphenylhydroxymethyl) pyrrolidine hammoho le trimethylboroxine kapa methylboronic acid.Ke sesebelisoa se setle sa ho kopanya joala ka tekanyo e phahameng ea enantiomeric.Ka kakaretso, 2-10 mol% ea catalyst ena e sebelisoa hammoho le borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N, N-diethylaniline, kapa diborane e le mohloli oa borane.Ho fokotseha ha Enantioselective ho sebelisa li-catalysts tsa chiral oxazaborolidine ho 'nile ha sebelisoa ha ho etsoa lithethefatsi tsa khoebo tse kang ezetimibe le aprepitant.