(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem le Darifenacin hydrobromide Intermediate
Phepelo ea Moetsi;Bohloeki bo Phahameng le Theko ea Tlholisano
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S) -3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Bohareng ba Panipenem (CAS 87726-17-8) le Darifenacin hydrobromide (CAS 133099-07-7)
| Lebitso la Lik'hemik'hale | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Litlhaloso tse tšoanang | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Nomoro ea CAS | 104706-47-0 |
| Nomoro ea KAtse | RF-CC102 |
| Mokhoa oa Bohloeki / Analysis | ≥98.0% (GC) |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C4H10ClNO |
| Boima ba Molek'hule | 123.58 |
| Melting Point | 107.0 ~ 111.0 °C |
| Sollubility ka Metsing | Hoo e ka bang Ponaletso |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Off-White ho Pale Brown Crystalline Powder |
| Mokhoa oa Bohloeki / Analysis | ≥99.7% (GC) |
| Chiral Purity | ≥99.7% ee |
| Masalla a ho Ignition | ≤0.50% |
| Potoloho e Khethehileng [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Tšilafalo efe kapa efe ea Motho ka Mong | ≤0.20% |
| Litšila kaofela | ≤0.30% |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Li-Intermediates tsa Meriana;Metsoako ea Chiral |
Mokhoa oa ho hlahloba
Thepa: Sesebelisoa sa GC (Shimadzu GC-2010)
Kholomo: DB-17 Agilent 30mX0.53mmX1.0μm
Mocheso oa pele oa ontong: 80 ℃
Nako ea pele 2.0min
Reiti 15℃/min
Mocheso oa ho qetela oa ontong: 250 ℃
Nako ea ho qetela 20min
Khase e tsamaisang Nitrogen
Mokhoa oa ho phalla kamehla
Phallo 5.0mL/min
Arohane karo-karolelano ea 10: 1
Mocheso oa ente: 250 ℃
Mocheso oa detector: 300 ℃
Bophahamo ba ente 1.0μL
Mehato e lokelang ho nkuoa pele ho tlhahlobo:
1. Kholomo ea boemo ho 240℃ bakeng sa bonyane metsotso e 30.
2. Hlatsoa syringe 'me u hloekise liner ea ente hantle ho tlosa litšila tsa tlhahlobo ea pejana.
3. Hlatsoa, o omise, 'me u tlatse metsi ka har'a linkho tsa ho hlatsoa seringe.
Boitokisetso ba diluent:
Lokisetsa tharollo ea 2% w / v sodium hydroxide ka metsing.
Tokisetso e tloaelehileng:
Beha boima ba hoo e ka bang 100mg ya (R) -3-hydroxyprrolidine hydrochloride standard ho ba vial, eketsa 1mL ya diluent mme o qhale.
Tokisetso ea liteko:
Beha boima ba 100mg ea sampole ea tlhahlobo ka har'a vial, eketsa 1mL ea diluent mme o qhale.Lokisetsa ka koporo.
Mokhoa:
Ente e se nang letho (diluent), boitokiso bo tloaelehileng le boitokisetso ba liteko u sebelisa maemo a kaholimo ho GC.Hlokomoloha litlhōrō ka lebaka la ho hloka letho.Nako ea ho boloka tlhōrō ka lebaka la (R) -3-hydroxyprrolidine e ka bang 5.0min.
Hlokomela:
Tlaleha sephetho joalo ka karolelano
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong le mofani oa thepa (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) e nang le boleng bo phahameng, e sebelisoang haholo ho organic synthesis, synthesis of intermediates ea meriana. le motsoako oa Active Pharmaceutical Ingredient (API).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ke ea bohareng ka tloaelo ho synthesis ea Panipenem (CAS 87726-17-8) le Darifenacin hydrobromide (CAS 133099-07-7).
(R) - (-) -3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ke chiral hydroxy derivative ea pyrrlodine e sebelisoang ho lokisoa ha metsoako ea chiral niologically active e kang bahanyetsi ba muscarinic receptor le li-antimicrobial agents.
Tsela ea Synthesis ea (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile e ile ea etsoa ka trimethyl chlorosilane ka har'a motsoako oa dichloromethane ho fumana (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine ka nako eo e ne e hydrogenated ka Pd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine e ile ea fumanoa ka ho koala lesale la sodium hydroxide.Qetellong, (R) -3-hydroxypyrrolidine hydrochloride sehlahisoa se ile sa fumanoa ka phekolo ea concentrated hydrochloric acid 'me sehlopha sa tšireletso sa trimethylsilyl se ile sa tlosoa.
