Ramelteon Intermediate 12 CAS 1053239-39-6 Bohloeki > 98.0% (HPLC)
Moetsi ea ka Sehloohong le Mofani, Li-Intermediates tsa Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride |
| Litlhaloso tse tšoanang | Ramelteon Mahareng a 12;Ramelteon Stage-2 Ho se hloeke;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride |
| Nomoro ea CAS | 1053239-39-6 |
| Nomoro ea KAtse | RF2887 |
| Boemo ba Setoko | Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane |
| Foromo ea limolek'hule | C13H18ClNO |
| Boima ba Molek'hule | 239.74 |
| Melting Point | 165.0 ~ 167.0 ℃ |
| Botenya | 1.058±0.06 g/cm3 |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo e tiileng e tiileng ho isa ho e tšoeu |
| Mokhoa oa Bohloeki / Analysis | >98.0% (HPLC) |
| Tahlehelo ka ho Omisa | <1.00% |
| Tšilafalo e le Mong | <1.00% |
| Litšila ka Kakaretso | <2.00% |
| 1 H NMR Spectrum | E Lumellanang le Sebopeho |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | Bohareng ba Ramelteon (CAS: 196597-26-9) |
Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) ke bohareng ba Ramelteon (CAS: 196597- 26-9).Ho fapana le liphekolo tse ngata tsa ho hlobaela tse lebisang ho GABA (g-aminobutyric acid) receptor complex, Ramelteon ke agonist ea melatonin receptor.Haholo-holo, e na le khetho e phahameng bakeng sa li-subtypes tsa MT1 le MT2, tse kentsoeng tlhokomelong ea li-circadian rhythms, holim'a receptor ea MT3 e ikarabellang bakeng sa mesebetsi e meng ea melatonin.Ho haella ha setsoalle ha se feela GABA receptor complex empa hape le neurotransmitter, dopaminerigic, opiate, le benzodiazepine receptors e fana ka maikutlo a ntlafatso ea ts'ireletso e se nang matla a tlhekefetso ea lithethefatsi tsa hypnotic tse lebisitseng li-receptor tsena.Ka hona, Ramelteon ha se lithethefatsi tse reriloeng.Metabolite ea mantlha e kenyelletsa hydroxylation le oxidation ho mefuta ea carbonyl e nang le metabolite ea bobeli e bakoang ke glucuronidation.Kaha CYP1A2 ke isozyme e kholo e amehang ho metabolism ea sebete ea Ramelteon, ha ea lokela ho nkoa hammoho le li-inhibitors tse matla tsa CYP1A2, tse kang fluvoxamine.Tšebelisano 'moho le ketoconazole (CYP3A4 inhibitor) kapa fluconazole (e matla CYP2C9 inhibitor) e ile ea fella ka keketseho e kholo ea AUC le Cmax, empa metabolism e pharalletseng le ho feto-fetoha ha maemo a phahameng a plasma ea Ramelteon li sitisitse tlhoko ea ho fetoloa ha lethal dose.Leha ho le joalo, sephutheloana sa sephutheloana se hlokomelisa bakuli ka ho sebelisana 'moho le li-inhibitors tse matla tsa CYP3A4 le CYP2C9.Ho ipapisitsoe le sephetho sa liteko tsa tleliniki, tekanyetso e khothaletsoang ea Ramelteon ke 8mg e nkuoeng nakong ea metsotso e 30 ho tloha ho robala.Ntle le tlhokomeliso ea ts'ebelisano-'moho le CYP inhibitors, ha ea lokela ho sebelisoa ho bakuli ba nang le bokooa bo matla ba sebete.Liketsahalo tse mpe, tse hlokometsoeng ho 5% ea bakuli lithutong tsa bongaka, e ne e le ho hlobaela, ho tsekela, ho nyekeloa ke pelo, mokhathala, hlooho le ho hlobaela.
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Ramelteon (TAK-375) CAS 196597-26-9 Bohloeki >99....
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