Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Setšoantšo sa Boleng bo Phahameng se Hlahisitsoeng

Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Boleng bo Phahameng

Tlhaloso e Khutšoanyane:

Lebitso la Lik'hemik'hale: Remdesivir (GS-5734)

CAS: 1809249-37-3

Ponahalo: Phofo e tiileng e tiileng ho isa ho e tšoeu

Tekanyo: 98.0% ~ 102.0%

Remdesivir bakeng sa kalafo ea COVID-19

API Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Remdesivir ea Phepelo ea Khoebo le Litšehare tse Amanang le Boleng bo Phahameng
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 ea Hare CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Remdesivir
Litlhaloso tse tšoanang	GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Nomoro ea CAS	1809249-37-3
Nomoro ea KAtse	RF-API96
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	Setšoantšo sa C27H35N6O8P
Boima ba Molek'hule	602.58
Botenya	1.47±0.1 g/cm3
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tiileng e tiileng ho isa ho e tšoeu
Boitsebiso A	IR: Maqhubu a ho monya ha infrared a sehlahisoa a lokela ho lumellana le a ntho ea litšupiso.
Boitsebiso B	HPLC Nako ea ho boloka e tšoana le ntho ea litšupiso
Phetoho e khethehileng	-19.0° ~ -22.0°
Solubility	Solunle ka Methanol, ha e Haholoane ka Ethanol, E Hanyenyane Hanyenyane ka Acetonitrile, Ha e khone ho qhibiliha ka Metsing
Lintho Tse Amanang
Tšilafalo efe kapa efe ea Motho ka Mong	≤0.10%
Litšila ka Kakaretso	≤1.0%
RD-3.1	≤0.10%
RD-C	≤0.10%
RD-D	≤0.10%
RD-E	≤0.10%
RP-Isomer	≤0.10%
Nitrophenol	≤0.10%
Metsoako e setseng
Methanol Dichloride	≤6000ppm
Acetone	≤5000ppm
Joala ba Isopropyl	≤5000ppm
Acetonitrile	≤410ppm
Dichloromethane	≤600ppm
Methyl tert Butyl Ether	≤5000ppm
Ethyl Acetate	≤5000ppm
Tetrahydrofuran	≤720ppm
n-Heptane	≤5000ppm
Tlhahlobo	98.0% ~ 102.0% (E baloa ka mokhoa o omisitsoeng)
Kakaretso ea Lipalo tsa Aerobic
Baktheria ea Aerobic	≤100cfu/g
Tomoso le hlobo	≤10cfu/g
E. Koele	E mpe
Endotoxin ea baktheria	≤1.0EU
Litšepe tse boima	≤20ppm
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API, COVID-19

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Remdesivir (CAS 1809249-37-3), e rekisoang ka lebitso la Veklury, ke moriana o thibelang likokoana-hloko o pharalletseng o entsoeng ke k'hamphani ea biopharmaceutical Gilead Sciences.E tsamaisoa ka ente ka har'a mothapo.Nakong ea seoa sa COVID-19, remdesivir e ile ea amoheloa kapa ea lumelloa bakeng sa tšebeliso ea tšohanyetso ho phekola COVID-19 linaheng tse ka bang 50.Litaelo tse ntlafalitsoeng ho tsoa ho Mokhatlo oa Lefatše oa Bophelo ka Pulungoana 2020 li kenyelletsa khothaletso e nang le maemo khahlano le ts'ebeliso ea Remdesivir bakeng sa kalafo ea COVID-19.Remdesivir qalong e ne e etselitsoe ho phekola lefu la hepatitis C, 'me hamorao e ile ea fuputsoa bakeng sa lefu la vaerase ea Ebola le tšoaetso ea vaerase ea Marburg pele e ithutoa joalo ka kalafo ea kamora ts'oaetso bakeng sa COVID-19.Litlamorao tse atileng haholo ho baithaopi ba phetseng hantle ke maemo a phahamisitsoeng a mali a li-enzyme tsa sebete (letšoao la mathata a sebete).Litlamorao tse atileng haholo ho batho ba nang le COVID-19 ke ho nyekeloa ke pelo.Litla-morao li ka kenyelletsa ho ruruha ha sebete le karabelo e amanang le infusion ka ho nyekeloa ke pelo, khatello e tlase ea mali le ho fufuleloa.Remdesivir ke prodrug e reretsoeng ho lumella ho tsamaisoa ha intracellular ea GS-441524 monophosphate le biotransformation e latelang ho GS-441524 triphosphate, ribonucleotide analogue inhibitor ea viral RNA polymerase.