Rivastigmine Tartrate CAS 129101-54-8 Assay 98.0~102.0
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Rivastigmine Tartrate (CAS: 129101-54-8) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Rivastigmine Tartrate |
| Litlhaloso tse tšoanang | Exelon;ENA-713;Rivastigmine L-Tartrate;Rivastigmine Hydrogen Tartrate;CS-118;S-Rivastigmine Tartrate;3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-Methylcarbamate L-Tartrate;N-Ethyl-N-Methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Boemo ba Setoko | Ka Stock, Tlhahiso ea Khoebo |
| Nomoro ea CAS | 129101-54-8 |
| CAS e amanang le eona | 123441-03-2 |
| Foromo ea limolek'hule | C14H22N2O2·C4H6O6 |
| Boima ba Molek'hule | 400.43 g / mol |
| Melting Point | 124.0 ho isa ho 128.0 ℃ |
| Phetoho e khethehileng [a]20/D | +4.0° ho ea ho +7.0° (C=5, Methanol) |
| Solubility | E qhibiliha ka Methanol |
| COA & MSDS | E fumaneha |
| Tšimoloho | Shanghai, China |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu | E lumellana |
| Tlhahlobo | 98.0 ~ 102.0% (Motheong oa Anhydrous) | 99.8% |
| Metsi ka Karl Fischer | ≤0.50% | 0.15% |
| Masalla a ho Ignition | ≤0.10% | 0.07% |
| Litšepe tse boima (Pb) | ≤20ppm | <10ppm |
| Phenol Tšilafalo | ≤0.30% | <0.30% |
| DPTTA | ≤0.15% | <0.15% |
| Leha e le Ho se hloeke | ≤0.15% | <0.15% |
| Ho se hloeke ha Carbamate | ≤0.15% | <0.15% |
| Ho se hloeke ha Ether | ≤0.15% | <0.15% |
| Tšilafalo E 'ngoe | ≤0.10% | <0.10% |
| Litšila kaofela | ≤0.50% | <0.50% |
| R-Enantiomer | ≤0.30% | <0.30% |
| Infrared Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| 1H NMR Spectrum | E tsamaellanang le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le USP35 Standard | |
Sephutheloana:Botlolo ea Fluorinated, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho latela tlhoko ea moreki.
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Rivastigmine Tartrate
C14H22N2O2·C4H6O6 400.42
Ethylmethylcarbamic acid, 3-[(S) -1-(dimethylamino)ethyl]phenyl ester, (2R,3R) -2,3-dihydroxybutanedioate;
(S) -3- [1- (Dimethylamino) ethyl] phenyl ethylmethylcarbamate, tartrate ea hydrogen [129101-54-8].
Rivastigmine 250.34 [123441-03-2].
TLHALOSO
Rivastigmine Tartrate e na le NLT 98.0% le NMT 102.0% ea palo e ngotsoeng ea C14H22N2O2·C4H6O6, e baloang ho latela anhydrous.
TS'ELISO TS'OANE
• A. Infrared Absorption <197K>
• B. Nako ea ho boloka tlhōrō ea tlhōrō e kholo ea Sample tharollo e lumellana le ea Tharollo ea ho tšoaneleha ha Sisteme, joalokaha e fumanoe tekong ea Litšila tsa Organic, Mokhoa oa 2: Enantiomeric Purity.
TLHOKOMELO
• Tsamaiso
Buffer: 8.6 mg/mL ea monobasic ammonium phosphate.Fetola ka tharollo ea ammonia ho pH ea 7.0.
Mohato oa Mobile: Methanol, acetonitrile, le Buffer (15:15:70)
Tharollo ea ho tšoaneleha ha tsamaiso: 0.05 mg / mL e 'ngoe le e' ngoe ea USP Rivastigmine Related Compound A RS le USP Rivastigmine Related Compound B RS in Mobile phase
Tharollo e tloaelehileng: 0.2 mg / mL ea USP Rivastigmine Tartrate RS karolong ea Mobile
Tharollo ea mohlala: 0.2 mg / mL ea Rivastigmine Tartrate ka Mobile phase
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: LC
Sesebelisoa: UV 215 nm
Kholomo: 4.6-mm × 25-cm;5-µm e paka L7
Sekhahla sa phallo: 1.2 mL / min
Boholo ba ente: 20 µL
[Tlhokomeliso-Sekhahla sa phallo se ka fetoloa ho 1.5 mL / min, ha ho hlokahala, ho finyella nako e khothalletsoang ea ho boloka rivastigmine hoo e ka bang 10 min.]
Ho nepahala ha sistimi
Mehlala: Tharollo ea ho tšoaneleha ha Sisteme le tharollo e Tloaelehileng
Litlhoko tsa ho tšoaneleha
Qeto: NLT 1.5 pakeng tsa motsoako o amanang le rivastigmine A le motsoako o amanang le rivastigmine B, tharollo ea ho tšoaneleha ha Sisteme
Katleho ea kholomo: lipoleiti tsa theoretical tsa NLT 5000, Tharollo e tloaelehileng
Ntlha ea bohlokoa: NMT 3.0, Tharollo e tloaelehileng
Phapang e amanang le maemo: NMT 2.0%, Tharollo e tloaelehileng
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala liperesente tsa C14H22N2O2·C4H6O6 karolong ea Rivastigmine Tartrate e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × 100
rU = karabelo e phahameng ho tsoa ho Sample solution
rS = karabelo ea tlhōrō ho tsoa ho tharollo e tloaelehileng
CS = mahloriso a tharollo e tloaelehileng (mg/mL)
CU = mahloriso a tharollo ea Mohlala (mg/mL)
Mekhoa ea ho amohela: 98.0% -102.0% motheong oa anhydrous
LITŠILA
Tšilafalo ea Inorganic
• Masalla a ho Ignition <281>: NMT 0.1%
• Heavy Metals, Mokhoa oa II <231>: NMT 20 ppm
Litšila tsa Organic
• Mokhoa oa 1
Mohato oa selefouno le tharollo ea ho tšoaneleha ha Sisteme: Tsoela pele joalo ka ha ho laetsoe ho Assay.
Tharollo e tloaelehileng: 1.0 µg/mL ea USP Rivastigmine Tartrate RS in Mobile phase
Tharollo ea mohlala: 1.0 mg / mL ea Rivastigmine Tartrate ka Mobile phase
Sistimi ea Chromatographic: Tsoela pele joalo ka ha ho laetsoe ho Assay.
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Ho nepahala ha sistimi
Mehlala: Tharollo ea ho tšoaneleha ha Sisteme le tharollo e Tloaelehileng
Litlhoko tsa ho tšoaneleha
Qeto: NLT 1.5 pakeng tsa motsoako o amanang le rivastigmine A le motsoako o amanang le rivastigmine B, tharollo ea ho tšoaneleha ha Sisteme
Phapang e amanang le maemo: NMT 10%, Tharollo e tloaelehileng
Tlhahlobo [Tlhokomeliso-Nako ea ho matha ke makhetlo a 8 nako ea ho boloka tlhōrō ea rivastigmine.]
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala liperesente tsa ho se hloeke ha motho ka mong karolong ea Rivastigmine Tartrate e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × (1/F) × 100
rU = karabelo ea tlhoro bakeng sa ho se hloeke ka 'ngoe ho tsoa ho Sample solution
rS = karabelo ea tlhōrō ho tsoa ho tharollo e tloaelehileng
CS = mahloriso a USP Rivastigmine Tartrate RS ka har'a tharollo e tloaelehileng (mg/mL)
CU = mahloriso a Rivastigmine Tartrate ka Sample solution (mg/mL)
F = ntho e amanang le karabo (sheba Letlapa la 1 la Tšilafalo)
Mekhoa ea ho amohela
Litšila tsa motho ka mong: Sheba Lethathamo la 1 la Tšilafalo.
Kakaretso ea litšila: NMT 0.5%
Lethathamo la 1 la Tšilafalo
| Lebitso | Nako ea ho Boloka Nako | Ntho e Batlang Karabelo | Mekhoa ea Kamohelo NMT % |
| Tartrate | 0.18 | - | Hlokomoloha |
| Phenol purity | 0.28 | 1.6 | 0.3 |
| DPTTAb | 0.46 | 0.83 | 0.15 |
| Leha e le ho se hloeke | 0.57 | 1.2 | 0.15 |
| Rivastigmine | 1.0 | 1.0 | - |
| Carbamate e sa hloekang | 4.1 | 1.3 | 0.15 |
| Ether e sa hloekang | 6.5 | 1.4 | 0.15 |
| Tšilafalo efe kapa efe | - | 1.0 | 0.1 |
a (S) -3-[1-(Dimethylamino)ethyl]phenol.
b (+) -Di-(p-toluoyl) -d-tartaric acid (rivastigmine e amanang le motsoako A).
c (S) -3- [1- (Dimethylamino) ethyl] phenyl dimethylcarbamate (rivastigmine e amanang le motsoako oa B).
d 3-Nitrophenyl ethyl(methyl)carbamate.
e (S)-N,N-Dimethyl-1-[3-(4-nitrophenoxy)phenyl]ethanamine.
• Mokhoa oa 2: Bohloeki ba Enantiomeric
Buffer: Fetisetsa 1.78 g ea dibasic sodium phosphate dihydrate le 1.38 g ea monobasic sodium phosphate ka har'a flask ea volumetric ea 1000-mL.Qhibiliha 'me u hlapolle ka metsi ho ea bophahamong.Fetola ka asiti ya phosphoric ho pH ya 6.0.
Mohato oa mobile: Fetisetsa 20 mL ea acetonitrile le 205 µL ea N,N-dimethyloctylamine ho 1000-mL volumetric flask, 'me u hlapolle ka Buffer ho ea holimo.
Tharollo e tloaelehileng: 0.1 µg/mL ea USP Rivastigmine Tartrate R-Isomer RS in Mobile phase
Tharollo ea kutlo: 0.05 µg/mL ea USP Rivastigmine Tartrate R-Isomer RS in Mobile phase, Standard solution
Tharollo ea ho tšoaneleha ha Sisteme: 100 µg/mL ea USP Rivastigmine Tartrate RS le 0.1 µg/mL ea USP Rivastigmine Tartrate R-Isomer RS in Mobile phase
Tharollo ea mohlala: 100 µg/mL ea Rivastigmine Tartrate in Mobile phase
Sistimi ea chromatographic
(Sheba Chromatography <621>, Ho Hlokahala Sistimi.)
Mokhoa: LC
Sesebelisoa: UV 200 nm
Kholomo: 4.0-mm × 10-cm;ho paka L41
Sekhahla sa phallo: 0.5 mL / min
Boholo ba ente: 20 µL
Ho nepahala ha sistimi
Mehlala: Tharollo e tloaelehileng, tharollo ea Sensitivity, le tharollo ea ho tšoaneleha ha Sisteme
Litlhoko tsa ho tšoaneleha
Qeto: NLT 0.8 pakeng tsa litlhōrō tsa enantiomer, Tharollo ea ho tšoaneleha ha Sisteme
[Tlhokomeliso-Taelo ea elution ke R-enantiomer, e lateloa ke tlhoro ea rivastigmine, e leng S-enantiomer.]
Karo-karolelano ea pontšo-ho-lerata: NLT 10, tharollo ea kutlo
Phapang e amanang le maemo: NMT 10%, Tharollo e tloaelehileng
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala liperesente tsa R-enantiomer karolong ea Rivastigmine Tartrate e nkiloeng:
Sephetho = (rU/rS) × (CS/CU) × 100
rU = karabelo e phahameng ea R-enantiomer ho tsoa ho Sample solution
rS = karabelo e phahameng ea R-enantiomer ho tsoa tharollong ea Maemo
CS = khatello ea R-enantiomer ka har'a tharollo e tloaelehileng (µg/mL)
CU = mahloriso a Rivastigmine Tartrate ka Sample solution (µg/mL)
Mokhoa oa ho amohela: NMT 0.3% ea R-enantiomer
LITEKO TSEKO
• Boikemisetso ba Metsi, Mokhoa oa Ia <921>: NMT 0.5%
KEKELETSO LIHLOKO
• Sephutheloana le Ho Boloka: Li boloke ka har’a lijalo tse thata, ’me u li boloke mochesong oa kamore.
• USP Reference Standards <11>
USP Rivastigmine Tartrate RS
USP Rivastigmine Related Compound A RS
Di-p-toluoyl-d-(+)-tartaric acid monohydrate.
C20H20O9 404.37
USP Rivastigmine Related Compound B RS
N,N-Dimethylcarbamic acid-3--[1-(dimethylamino)ethyl]phenyl ester.
C13H20N2O2 236.32
USP Rivastigmine Tartrate R-Isomer RS
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
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Li-ID tsa UN UN 2811 6.1 / PGII
WGK Jeremane 3
RTECS FA9550000
HS Code 29242990
Sehlopha sa Likotsi 6.1
Sehlopha sa ho paka III
Rivastigmine Tartrate (CAS: 129101-54-8) ke tartrate ea rivastigmine, lithethefatsi bakeng sa phekolo ea lefu la Alzheimer's.Rivastigmine ke motsoako oa physostigmine, o ileng oa ntlafatsoa ka katleho lekhetlo la pele ke Novartis, Switzerland.Lebitso la khoebo ke exelon, 'me molek'hule e na le sebopeho sa benzyl carbamate, ke carbamate brain-selective cholinesterase inhibitor, e ka thibelang acetylcholinesterase le butyrylcholinesterase ka nako e le' ngoe, 'me e khothalletsa ts'ebetso ea methapo ea cholinergic ka ho lieha ho senyeha ha acetylcholine e lokolloa ke cholinergic. methapo ea kutlo.E ka ntlafatsa ts'ebetso ea ts'ebetso ea kelello e kenelletseng ke cholinergic, ka hona e ntlafatsa phello ea kelello ea bakuli ba nang le lefu la Alzheimer's.Matla a tlamang protheine ea plasma ea rivastigmine a fokola, ho bonolo ho feta mokoallong oa mali-boko, 'me o na le tekanyo e phahameng ea khetho ea boko.E ke ke ea khetha feela libakeng tse tlokotsing haholo tsa cerebral cortex le hippocampus, empa hape e thibela ka mokhoa o ikhethileng li-subtypes tse kholo tsa AChE bokong, tse ka fokotsang litlamorao tsa peripheral cholinergic ha li ntse li hlahisa litlamorao tsa kalafo.Halofo ea bophelo ba rivastigmine tartrate 'meleng e khutšoanyane' me nako ea ketso e telele.Ho fapana le tacrine, sehlahisoa sena se na le phello e matla ea thibelo ho enzyme ea G1 ho hippocampus le cortex.E sebelisoa ho ea ka bongaka ho phekola 'dementia' e bobebe ho isa ho e itekanetseng, e belaelloang ka lefu la Alzheimer kapa lefu la Alzheimer's.
1. Joaloka acetylcholinesterase inhibitor, rivastigmine bicartrate e ka ntlafatsa phello ea mesifa ea succinylcholine e phomolang.Ka hona, ho lokela ho ba le nako e loketseng ea ho emisa ho nka sehlahisoa sena pele ho anesthesia.Sehlahisoa sena se lokela ho kopanngoa le litokisetso tse ling tsa cholinergic kapa anticholinergic, 'me tlhokomelo e lokela ho nkoa (sheba [Tšebelisano ea Lithethefatsi]).
2. Ka lebaka la liphello tsa bona tsa meriana, li-inhibitors tsa cholinesterase li ka 'na tsa e-ba le liphello tsa khatello ea methapo ea vagus ka lebelo la pelo.Joalo ka litlhare tse ling tsa cholinergic, tlhokomeliso e lokela ho sebelisoa ha e fuoa bakuli ba nang le lefu la sinus syndrome kapa lefu le leng la pelo (sheba Likarabo tse mpe).
3. Thabo ea methapo ea cholinergic e ka baka ho eketseha ha asiti ea gastric.Leha ho se na bopaki ba ho senyeha ho hoholo ha matšoao a tšoanang nakong ea teko ea bongaka, bakuli ba nang le kotsi e kholo ea ho ba le seso sa ka mpeng, joalo ka ba nang le nalane ea lefu la seso kapa ba fumanang kalafo ka nako e tšoanang le lithethefatsi tse seng khahlanong le ho ruruha, e lokela ho sebelisoa ka hloko.
4. Joaloka li-inhibitors tse ling tsa cholinesterase, bakuli ba nang le histori ea asthma kapa mafu a mang a thibelang matšoafo ba lokela ho sebelisoa ka hloko.
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