Roflumilast CAS 162401-32-3 Assay 99.0~101.0% API

Tlhaloso e Khutšoanyane:

Lebitso la lik'hemik'hale: Roflumilast

CAS: 162401-32-3

Tekanyetso: 99.0 ~ 101.0% (E baloa ka Motheo o Omisitsoeng)

Ponahalo: Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu

API PDE-4 Inhibitor COPD

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Roflumilast Intermediates:
Roflumilast CAS 162401-32-3
4-Amino-3,5-Dichloropyridine CAS 22889-78-7

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Roflumilast
Litlhaloso tse tšoanang	3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-yl)-4-(Ddifluoromethoxy)benzamide
Nomoro ea CAS	162401-32-3
Nomoro ea KAtse	RF-PI2075
Boemo ba Setoko	Ka Setokong, Sekhahla sa Tlhahiso Ho fihlela ho Lithane
Foromo ea limolek'hule	C17H14Cl2F2N2O3
Boima ba Molek'hule	403.21
Botenya	1.471±0.060 g/cm3
Kutloisiso	Mocheso o Mamela
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo ea Crystalline e tšoeu kapa e batlang e le tšoeu
Solubility	E qhibiliha ka har'a acetone, e qhibiliha hanyenyane ka har'a acetronitrile, e sa qhibilihe hanyenyane ka ethanol ea anhydrous, e batlang e sa qhibilihe metsing.
Melting Point	157.0 ~ 162.0℃
Tahlehelo ka ho Omisa	<0.50%
Masalla a ho Ignition	≤0.10%
Litšepe tse boima	≤10ppm
Chloride	≤0.01%
Boitsebiso ba A. UV	Bophahamo ba maqhubu a ho monya ho lokela ho ba ho 213 ~ 251nm
Boitsebiso B. IR	Sekhahla sa ho monya sa IR sa sampole se lumellana le sa referense
Boitsebiso C.	E bontša karabelo ea Fluoride
Lintho Tse Amanang
Tšilafalo e le Mong	≤0.10%
Litšila ka Kakaretso	<0.50%
Metsoako e setseng
Tert-Butanol	<0.10%
Tetrahydrofuran	<0.072%
Toluene	<0.089%
N, N-Dimethylformamide	<0.088%
Tlhahlobo	99.0 ~ 101.0% (E baloa ka Motheo o Omisitsoeng)
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	API;COPD

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo

Melemo:

LBH:

Kopo:

Roflumilast (CAS: 162401-32-3) ke khetho ea oral phosphodiesterase-4 (PDE-4) inhibitor le motsoako oa benzamide.E ntlafalitsoe ke k'hamphani ea Jeremane ea Altana ka 1993 'me ke eona feela inhibitor ea molomo ea PDE-4 e sebelisoang ho phekola mafu a phefumoloho a lumelletsoeng ho rekisoa.Roflumilast ke setlhare sa pele sa mofuta oa sona se lebisang lefung le matla le sa foleng le sa foleng la matšoafo (COPD), hape ke setlhare sa pele sa molomo se khahlanong le ho ruruha se etselitsoeng bakuli ba COPD.Thepa ea eona e ikhethang e ka thusa ho laola COPD: ha e sebelisoa hammoho le li-bronchodilator ho phekola bakuli ba matla haholo ba COPD, Roflumilast e ka ba le monyetla oa ho fokotsa matšoao le sekhahla sa ho senyeha, kahoo e etsa hore e be moriana oa pele o lebisitseng ho bakuli ba nang le phenotype-spAecific COPD e ntseng e senyeha khafetsa. le tšitiso e matla ea moea e amanang le ho khohlela ho sa foleng le phlegm e feteletseng.Ntle le ho ba kalafo ea COPD e matla, Roflumilast e ka boela ea sebelisoa ho thibela le ho alafa mafu a phefumoloho ea mehlape, sefuba se feteletseng sa bronchitis, bronchitis ea asthmatic, le bronchitis e matla le sacculitis ea moea e tsamaeang le secretion e sa tloaelehang ea phefumoloho.