(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Intermediate Purity >99.0% (GC)

Tlhaloso e Khutšoanyane:

Lebitso la Lik'hemik'hale: (S)-1-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Chiral Purity: >99.0% (GC)

Bohloeki ba Lik'hemik'hale: >99.0% (GC)

Ponahalo: Phofo e tšoeu kapa likristale

Bohareng ba Ibrutinib (CAS: 936563-96-1)

Boleng bo Phahameng, Tlhahiso ea Khoebo

E-Mail: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Likahare tse Amanang le Ibrutinib:
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxyphenylboronic Acid CAS 51067-38-0
Ibrutinib Intermediate N-2 CAS 330786-24-8
Ibrutinib Intermediate N-3 CAS 330792-70-6
Ibrutinib CAS 936563-96-1

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	(S) -1-Boc-3-Hydroxypiperidine
Litlhaloso tse tšoanang	(S) -1-(tert-Butoxycarbonyl) -3-Hydroxypiperidine;(S)-1-Boc-3-Piperidinol
Nomoro ea CAS	143900-44-1
Nomoro ea KAtse	RF-CC299
Boemo ba Setoko	Ka Setokong, Bokhoni ba Tlhahiso 20 Tons/Khoeli
Foromo ea limolek'hule	C10H19NO3
Boima ba Molek'hule	201.27
Melting Point	52.0 ~ 56.0℃
Solubility	E qhibiliha ka Methanol
Phetoho e khethehileng [a]20/D	+9.0°~+11.0° (C=1 ka Chloroform)
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e tšoeu kapa Likristale
Chiral Purity	>99.5% (GC)
Bohloeki ba Lik'hemik'hale	>99.5% (GC)
Metsi (KF)	≤0.50%
Methanol (GC)	≤50ppm
Ethanol (GC)	≤50ppm
DCM (GC)	≤500ppm
3-Hydroxypiperidine	≤0.10%
3-Hydroxypyridine	≤0.20%
1-Boc-3-Piperidone	≤0.10%
1-Boc-4-Hydroxypiperidine	≤0.10%
1.96 RRT	≤0.20%
Tšilafalo efe kapa efe e sa Boleloeng	≤0.10%
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Li-Intermediates tsa Meriana;Metsoako ea Chiral

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo.

Melemo:

LBH:

Kopo:

(S) -1-Boc-3-Hydroxypiperidine (CAS: 143900-44-1) ke setsi sa bohlokoa sa chiral bakeng sa motsoako oa Ibrutinib (CAS: 936563-96-1).Ibrutinib ke mofuta oa Bruton tyrosine kinase (BTK) inhibitor, e ka sebelisoa bakeng sa kalafo ea chronic lymphocytic leukemia (CLL) le mantle cell lymphoma (MCL).MCL le CLL ke tsa B-cell non-Hodgkin's lymphoma, eo ho leng thata ho e phekola le ho ipheta habonolo.Lik'hemik'hale tse tloaelehileng tsa immunotherapy ha li na sepheo, hangata li hlaha 3 kapa 4 karabelo e mpe.Li-lymphocyte tsa Ibrutinib le B li ne li ka shebana le BTK e hlokahalang bakeng sa ho thehoa, ho arola, le ho fetisa boitsebiso, ho thibela mosebetsi oa BTK ka mokhoa o sa fetoheng, le ho thibela ho ata ha lisele tsa hlahala le ho phela ka katleho.Ibrutinib e ka kenngoa ka potlako ka mor'a ho tsamaisoa ka molomo, nakong ea 1 ~ 2h e fihla ho bongata ba mali maling, karabelo e mpe ke ea motho a le mong kapa tse peli, ka hona, Ibrutinib e tla fetoha khetho e ncha ea kalafo ea CLL le MCL.