Sorafenib Tosylate CAS 475207-59-1 Purity ≥99.0% (HPLC) API Factory High Quality
Phepelo ea Khoebo Sorafenib Tosylate le Li-Intermediate tse Amanang:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Lebitso la Lik'hemik'hale | Sorafenib Tosylate |
| Litlhaloso tse tšoanang | Nexavar;4-[4-[3-[4-Chloro-3-(Trifluoromethyl)phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Nomoro ea CAS | 475207-59-1 |
| Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
| Foromo ea limolek'hule | C21H16ClF3N4O3.C7H8O3S |
| Boima ba Molek'hule | 637.03 |
| Melting Point | 225.0 ho isa ho 230.0 ℃ |
| E hloahloa | Ha e Mamelle Moeeng, Ha e Mamele Mocheso |
| Solubility | Soluble ka Metsing (<1 mg/ml) ho 25℃, DMSO (127 mg/ml) ho 25℃, le Ethanol (<1 mg/ml) ho 25℃ |
| Maemo a ho Romela | Sebaka se Pholile & se Omileng (2~8℃), Sireletsa Leseling |
| COA & MSDS | E fumaneha |
| Shelf Life | Lilemo tse 2 haeba li bolokiloe hantle |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso | Liphetho |
| Ponahalo | Phofo e Bosehla kapa Bosweu bo Kganyang | E lumellana |
| Mokhoa oa Bohloeki / Analysis | ≥99.0% (HPLC) | 99.8% |
| Melting Point | 225.0~230.0℃ | E lumellana |
| Litšepe tse boima | ≤10ppm | <10ppm |
| Tahlehelo ka ho Omisa | ≤0.50% | 0.12% |
| Masalla a ho Ignition | ≤0.20% | 0.10% |
| Tšilafalo efe kapa efe e le 'Ngoe | ≤0.50% | E lumellana |
| Litšila ka Kakaretso | ≤0.50% | E lumellana |
| Sekhahla sa NMR | E Ikamahanya le Sebopeho | E lumellana |
| Tekanyetso ea Teko | Maemo a Khoebo | E lumellana |
| Tšebeliso | Sorafenib Tosylate (CAS: 475207-59-1) kalafo ea RCC & HCC | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka setshelo se koetsoeng ka thata.Boloka sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
Likhoutu tsa Kotsi 36/37/38 - Ho hlohlona mahlong, tsamaiso ea ho hema le letlalo.
Tlhaloso ea Tšireletseho S28 - Ka mor'a ho kopana le letlalo, hlatsoa hang-hang ka sesepa e ngata ea sesepa.
S26 - Ha u kopana le mahlo, hlatsoa hang-hang ka metsi a mangata 'me u batle keletso ea bongaka.
Sorafenib Tosylate (CAS: 475207-59-1) ke mofuta o mocha oa lithethefatsi tse thibelang likokoana-hloko tse ngata, tse entsoeng ke Jeremane Bayer Pharmaceuticals, 'me li bonts'a ts'ebetso e matla ea antitumor litekong tsa pele tsa liphoofolo.Sorafenib e fumaneha ka matlapa a 200-mg bakeng sa tsamaiso ea molomo 'me e sebelisoa ho phekola RCC le HCC.Sorafenib Tosylate e ka ama ka nako e le 'ngoe lisele tsa tumor le methapo ea mali ea tumor.E na le phello e 'meli ea antitumor: e ka thibela litsela tsa phetisetso ea lisele tse kentsoeng ke RAF / MEK / ERK ho thibela ka ho toba ho hōla ha lisele tsa tumor, ha e ntse e thibela VEGF le platelet derived growth factor (PDGF) ho thibela ho thehoa ha mali a macha. lijana, kahoo ka tsela e sa tobang thibela ho hōla ha lisele tsa hlahala.
Sorafenib Tosylate, lebitso la khoebo Nexavar, e qalile ho hlahisoa ke Bayer Pharmaceuticals Jeremane.Sorafenib Tosylate ke multikinase inhibitor e ka sebelisoang ho phekola mafu a kang mofetše.Ka Tšitoe 2005, e ile ea amoheloa ke US FDA e le moriana oa pele bakeng sa kalafo ea mofetše o tsoetseng pele oa renal.Ka Phato 2009, e ile ea ngolisoa ka molao Chaena ka tumello ea Tsamaiso ea Naha ea Lijo le Lithethefatsi.
Sorafenib Tosylate ke tyrosine kinases (VEGFR le PDGFR) le RAF/MEK/ERK cascade inhibitors, e sebetsang ka nako e le ’ngoe ho Raf-1,wtBRAF le V599EBRAF, le IC50 ea 6 nM, 22 nM le 38 nM, ka ho latellana.
Sorafenib Tosylate ka nako e le 'ngoe e ka thibela mefuta e fapaneng ea li-kinase tse teng seleng le holim'a sele, ho kenyelletsa le RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet. -derived growth factor receptor-β (PDGFR-β), KIT le FLT-3.Hoa hlokomeleha hore sorafenib toluenesulfonate e na le litlamorao tse peli tsa anti-tumor.Ka lehlakoreng le leng, e ka thibela ka ho toba ho hōla ha hlahala ka ho thibela tsela ea pontšo ea RAF / MEK / ERK;ka lehlakoreng le leng, e ka thibela VEGFR le PDGFR.Le ho thibela sebopeho sa tumor neovascularization, ka tsela e sa tobang thibela kholo ea lisele tsa hlahala.Sorafenib Tosylate ke setlhare se sebetsang ka ho fetesisa bakeng sa kalafo ea mofetše oa sebete o ntseng o tsoela pele ka tsamaiso ea tsamaiso, 'me mohlomong e tla fetoha setlhare se secha se tloaelehileng bakeng sa kalafo ea lefu lena.
Sorafenib Tosylate hanngoe ka letsatsi tsamaiso ea molomo ea mefuta ea phetisetso ea lihlahala tsa motho e bontšitse mesebetsi e mengata e khahlanong le hlahala, ho kenyeletsoa mofetše oa colon, kankere ea matsoele e seng e nyane, mofetše oa matsoele, melanoma, mofets'e oa pancreatic, leukemia le mofets'e oa mahe a bomme le mouse renal cell carcinoma. mohlala, mohlala oa RENCA.
