Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV High Quality

Tlhaloso e Khutšoanyane:

Lebitso: Tenofovir Alafenamide Hemifumarate (TAF)

CAS: 1392275-56-7

Bosweu ho isa ho bosweu bo ka bang Tjhweu kapa Phofo ya Crystalline

Tekanyo: 98.0% ~ 102.0%

Sehlahisoa sa Tenofovir, se sebelisoang kalafong e kopaneng bakeng sa kalafo ea Tšoaetso ea HIV-1

Boleng bo Phahameng, Tlhahiso ea Khoebo

Inquiry: alvin@ruifuchem.com

Re romelle lengolo-tsoibila

Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Mekhatlo e Amanang ea Phepelo ea Tenofovir:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl Isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Tenofovir Alafenamide Hemifumarate
Litlhaloso tse tšoanang	TAF;GS-7340 Hemifumarate
Nomoro ea CAS	1392275-56-7
Nomoro ea KAtse	RF-API91
Boemo ba Setoko	Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma
Foromo ea limolek'hule	Setšoantšo sa C25H33N6O9P
Boima ba Molek'hule	592.55
Mocheso oa polokelo	E tiisitsoe ka Mocheso o omileng, oa Kamore
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Bosweu ho isa ho bosweu bo ka bang Tjhweu kapa Phofo ya Crystalline
Solubility	E qhibiliha ka Dimethylformamide, le Methanol;Haholo qhibilihang ka Metsing le THF;Ha e qhibilihe ka har'a Acetonitrile 'me ha e khone ho qhibiliha ho Dichloromethane le Toluene.
Boitsebiso A	Pono ea ho monya ea IR e lokela ho lumellana le referense
Boitsebiso B	Nako ea ho boloka tlhoro e kholo ea tharollo ea sampole ho chromatogram ea boikemisetso e lumellana le ea tharollo ea litšupiso.
Boitsebiso C	Nako ea ho boloka Fumaric Acid ea tlhoro e kholo ho chromatogram ea boikemisetso ba litaba e lumellana le tlhoro ea litšupiso.
Litaba tsa Metsi (ka KF)	≤1.0%
Ho Hlakola ha Tharollo	Ha e le hantle ha ho na likaroloana tse bonahalang ho 2% (w / v) ea tlhaloso ea Tharollo ea Methanol
Residual Solvent
Acetonitrile	≤410ppm
Ethanol	≤5000ppm
Dichloromethane	≤600ppm
Toluene	≤890ppm
Masalla a ho Ignition	≤0.10%
Litšepe tse boima	≤20ppm
Lintho Tse Amanang
PMPA	≤1.0%
Anhydride ea PMPA	≤0.75%
Phenyl PMPA e le 'ngoe	≤1.0%
Tšilafalo efe kapa efe e sa Boleloeng	≤0.15%
Litšila ka Kakaretso	≤2.0%
Isomer	≤1.0%
Litaba tsa Fumaric Acid	9.0% ~ 13.0% (motheong oa anhydrous)
Meeli ea Likokoana-hloko
Kakaretso ea Aerobic Microbial Count	≤1000CFU/g
Kakaretso ea Litomoso le hlobo li baloa	≤100CFU/g
Escherichia Coli	Absent
Tlhahlobo	98.0% ~ 102.0% (motheong oa anhydrous le o se nang solvent)
Tekanyetso ea Teko	Maemo a Khoebo

Sephutheloana le Bobolokelo:

Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.

Melemo:

LBH:

Kopo:

Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, ke nucleotide reverse transcriptase inhibitor (NRTIs) le prodrug e ncha ea Tenofovir (TFV).Ka ho thibela reverse transcriptase, TAF e thibela HIV ho ikatisa 'me e ka fokotsa bongata ba HIV' meleng.Tenofovir alafenamide ke moriana, ho bolelang hore ke sethethefatsi se sa sebetseng.'Meleng, tenofovir alafenamide e fetoleloa ho Tenofovir diphosphate (TFV-DP).Tenofovir Alafenamide Fumarate e ananetswe ka Pudungwana 2015 bakeng sa kalafo ya HIV-1.