trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity >98.0% (HPLC) Afatinib Dimaleate Intermediate

Tlhaloso e Khutšoanyane:

Trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Bohloeki: >98.0% (HPLC)

Ponahalo: Bosoeu ho isa ho Phofo e Batlileng e e Tsweu

Bohareng ba Afatinib Dimaleate (CAS: 850140-73-7)

Ikopanye le: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Lintlha tsa Sehlahisoa

Lihlahisoa tse Amanang

Li-tag tsa Sehlahisoa

Tlhaloso:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H)-e le 'ngoe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Lintho tsa Lik'hemik'hale:

Lebitso la Lik'hemik'hale	Trans-4-Dimethylaminocrotonic Acid Hydrochloride
Litlhaloso tse tšoanang	trans 4-Dimethylaminocrotonic Acid HCl;(E) -4-(Dimethylamino) -2-Butenoic Acid Hydrochloride;(E) -4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) empa-2-Enoic Acid Hydrochloride;Afatinib int-2
Nomoro ea CAS	848133-35-7
Boemo ba Setoko	Ho Stock, Commercial Scale
Foromo ea limolek'hule	C6H12ClNO2
Boima ba Molek'hule	165.62
Kutloisiso	Hygroscopic.E Mamela Mongobo
Melting Point	160.0 ho isa ho 164.0 ℃
Solubility	DMSO (Hanyenyane), Methanol (Hanyenyane), Metsi (Hanyenyane)
COA & MSDS	E fumaneha
Tšimoloho	Shanghai, China
Brand	Ruifu Chemical

Litlhaloso:

Ntho	Litlhaloso
Ponahalo	Phofo e Bosoeu ho isa ho e Batlileng e Tsweu
Mokhoa oa Bohloeki / Analysis	>98.0% (HPLC)
Mokhoa oa Bohloeki / Analysis	>98.0% (NMR)
Mongobo (KF)	<0.50%
Masalla a ho Ignition	<0.20%
Tšilafalo e le Mong	<0.50%
Heavy Metals (as Pb)	<20ppm
Infrared Spectrum	E Ikamahanya le Sebopeho
1 H NMR Spectrum	Proton NMR Spectrum
Tekanyetso ea Teko	Maemo a Khoebo
Tšebeliso	Bohareng ba Afatinib, Afatinib Dimaleate

Sephutheloana le Bobolokelo:

Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.

Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa leseli le mongobo.

Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.

Chromatographic Purity:

Sesebelisoa: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Kholomo: Agilent XDB-C18,250 * 4.6mm, 5μm
Mokhahlelo oa selefouno: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml metsi
C: acetonitrile
Tokisetso ea mokhahlelo o tsoakiloeng oa selefouno: nka tharollo ea 400ml B le 100ml acetonitrile, kopanya hantle le ka ho lekana, 'me u pompe mokelikeli ka mohato o le mong.
Sekhahla sa phallo: 0.5ml/min54bar
Mocheso oa kholomo: 25 ℃
Wavelength: 210nm
Tharollo ea mohlala: mohato oa selefouno o ne o sebelisoa e le solvent, sampole e tiileng: 0.0040g/2ml, boholo ba sampuli 2.0μl.

Melemo:

LBH:

Kopo:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) ke reagent e sebelisoang ha ho etsoa litokisetso tsa tyrosine kinase inhibiting antitumor agents.trans-4-Dimethylaminocrotonic Acid Hydrochloride e ka sebelisoa e le bohareng ba Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib ke sethethefatsi se amohetsoeng bakeng sa kalafo e seng e nyane ea cell lung carcinoma (NSCLC), e ntlafalitsoeng ke Boehringer Ingelheim.E sebetsa joalo ka angiokinase inhibitor.Joalo ka Lapatinib le Neratinib, Afatinib ke tyrosine kinase inhibitor (TKI) eo hape e thibelang motho epidermal growth factor receptor 2 (Her2) le epidermal growth factor receptor (EGFR) kinases.Afatinib ha e sebetse feela khahlanong le EGFRliphetoho tse lebisitsoeng ke moloko oa pele oa TKIs likeerlotinib kapa gefitinib, empa hape le khahlanong le tse sa tsotelleng liphekolo tsena tse tloaelehileng.Ka lebaka la ts'ebetso ea eona e eketsehileng khahlano le Her2, e ntse e batlisisoa bakeng sa mofetše oa matsoele hammoho le mefuta e meng ea mofets'e oa EGFR le Her2.Neratinib e entsoeng ke k'hamphani ea US Wyeth ke inhibitor e ke keng ea fetoloa ea epidermal growth factor receptor(EGFR).Ke ntlha e 'maloa e shebiloeng ea molek'hule e nyane ea tyrosine kinase inhibitors ho HER 2 le HER1 kamora Lapatinib, mme ke ErbB receptor tyrosine kinase inhibitor e sa fetoheng.Neratinib e ne e ka khetha ho thibela HER-1 le HER-2 ea lelapa la EGFR (IC50 e ne e le 92 nmol / L le 59 nmol / L, ka ho latellana).Patlisiso ea bongaka e bonts'itse hore Neratinib e na le phello e kholo ea kalafo ho mofets'e o seng o monyane oa sele ea matšoafo, mofets'e oa colon le mofets'e oa matsoele.Teko ea phaseⅡclinical e bontšitse hore Neratinib e bontšitse katleho e ntle le mamello ho bakuli ba nang le HER-2 ba nang le mofetše oa matsoele o tsoetseng pele ba neng ba amohetse kapa ba sa phekoloe ka Trastuzumab.Karolo ea Ⅲ teko ea bongaka ea mofetše oa matsoele e phethetsoe ka Loetse 2014.