Vithamine E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd. ke moetsi ea ka sehloohong oa Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) e nang le boleng bo phahameng.Ruifu Chemical e ka fana ka lits'ebeletso tsa lefats'e ka bophara, theko ea tlholisano, litšebeletso tse ntle haholo, tse nyane le tse ngata tse fumanehang.Reka Vithamine E-TPGS,Please contact: alvin@ruifuchem.com
| Lebitso la Lik'hemik'hale | Vithamine E Polyethylene Glycol Succinate |
| Litlhaloso tse tšoanang | Vithamine E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Boemo ba Setoko | Ho Stock, Commercial Scale |
| Nomoro ea CAS | 9002-96-4 |
| Foromo ea limolek'hule | C33H54O5.(C2H4O)n |
| Melting Point | 34.0 ~ 38.0℃ |
| Botenya | 1.01g/cm3 |
| E hloahloa | Ha e na Moeeng, Ha e Mamelle Leseli, Ha e na Mongobo |
| WGK Jeremane | 2 |
| Mocheso oa polokelo. | Sebaka se pholileng le se omileng (2~8℃) |
| COA & MSDS | E fumaneha |
| Mohlala | E fumaneha |
| Lelapa la Lik'hemik'hale | Tlhahiso ea vithamine E |
| Brand | Ruifu Chemical |
| Lintho | Maemo a Tlhahlobo | Liphetho |
| Ponahalo | Bosoeu ho isa ho Bosehla bo Bosehla Waxy Tiileng | E lumellana |
| Boitsebiso (GC) | Nako ea ho boloka tlhōrō e kholo ea tharollo ea mohlala e lumellana le ea Tharollo e Tloaelehileng | E lumellana |
| Melting Point | 34.0 ~ 38.0℃ | 36.0 ~ 36.6 ℃ |
| Tlhahlobo ea D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol ea mahala | ≤1.5% | E lumellana |
| Phetoho e khethehileng | ≥+24.0° | +24,5 ° |
| Sollubility ka Metsing | 20g ea sampuli e ka qhibiliha ka metsi a belang a 80ml | Hlakola Nakong ea 3 h |
| Boleng ba Asiti | ≤0.27ml (0.10 N Sodium Hydrooxide) | 0.22ml |
| Litšepe tse boima (Pb) | ≤10ppm | <10ppm |
| Arsenic (As) | ≤1ppm | <1ppm |
| Ketapele | ≤3ppm | <3ppm |
| Mercury (Hg) | ≤0.1ppm | <0.010ppm |
| Metsoako e setseng | ||
| Ethyl Acetate | ≤50ppm | Ha e fumanwe |
| Ethanol | ≤50ppm | 23ppm |
| Kakaretso ea Plate Count | ≤1000CFU/g | <10CFU/g |
| Litomoso le hlobo | ≤100CFU/g | <10CFU/g |
| Salmonella | E mpe | E mpe |
| Escherichia Coli | E mpe | E mpe |
| Psendomonas Aeruginosa | E mpe | E mpe |
| Staphylococcus Aureus | E mpe | E mpe |
| Infrared Spectrum | E Ikamahanya le Sebopeho | E lumellana |
| Qetello | Sehlahisoa se lekoa 'me se lumellana le litlhaloso tse fanoeng | |
Sephutheloana:Botlolo, Aluminium foil bag, 25kg/Cardboard Drum, kapa ho ea ka tlhokahalo ea moreki.
Boemo ba polokelo:Boloka ka setshelo se koetsoeng ka thata.Boloka sebakeng se phodileng, se omeletseng (2~8℃) le se nang le moya o hlwekileng hole le dintho tse sa dumellaneng.Sireletsa leseli le mongobo.
Ho tsamaisa ka sekepe:Tsamaisa lefatšeng ka bophara ka sefofane, ka FedEx / DHL Express.Fana ka thomello e potlakileng le e tšepahalang.
TLHALOSO
Vithamine E Polyethylene Glycol Succinate ke motsoako o entsoeng ke esterification ea d-alpha tocopheryl acid succinate le polyethylene glycol.Motsoako oa ester o na le haholo-holo mono-esterified polyethylene glycol le palo e nyenyane ea di-esterified polyethylene glycol.E na le NLT 25.0% ea d-alpha tocopherol (C29H50O2).
TS'ELISO TS'OANE
• Teko ea Boitsebiso ea Khase ea Chromatographic
Tlhahlobo: Tsoela pele joalo ka ha ho laetsoe tlhahlobo ea Likahare tsa Alpha Tocopherol.
Mokhoa oa ho amohela: Nako ea ho boloka tlhoro e kholo ea tharollo ea Mohlala e lumellana le ea Tharollo ea Maemo.
MOTSAMAI
• Likahare tsa Alpha Tocopherol
Solvent: 0.25 mL ea phenolphthalein TS ho 1 L ea joala
Tharollo e tloaelehileng ea ka hare: 12 mg/mL ea ethyl arachidate ka isooctane
Tharollo e tloaelehileng: Fetisetsa 32.5 mg ea USP Alpha Tocopherol RS ho botlolo e loketseng ea ho arabela.Kenya 2 mL ea pyridine le 0.5 mL ea N, O-bis(trimethylsilyl) trifluoroacetamide ka 1% trimethylchlorosilane, 'me u chese flask ka 100 bakeng sa 10 min.Folisa botlolo, eketsa 5.0 mL ea tharollo e tloaelehileng ea ka hare e lateloang ke 20 mL ea isooctane, 'me u sisinyehe.
Mohlala oa tharollo: Fetisetsa bongata bo lekanang le 0.100–0.160 g ea Vitamin E Polyethylene Glycol Succinate e qhibilihisitsoeng ka 60 ho tube ea setso (e ka bang bolelele ba 20 cm le bophara ba 2.5 cm) e nang le sekoahelo sa screw.Eketsa 40-50 mg ea ascorbic acid le lichifi tse seng kae tse belang, ebe o lateloa ke 20 ml ea Solvent.[Tlhokomeliso—Reflux tharollo ka bonolo ntle le ho ntša litaba.] Beha tube ka har'a sebaka sa ho futhumatsa se behiloeng ho 100-150.Ha sampuli e qhibiliha ka ho feletseng, eketsa 0.25 g ea potassium hydroxide, 'me u tsoele pele ho reflux bakeng sa 30 min.Tlosa tube mochesong, 'me ha likahare li ntse li chesa, eketsa 1-2 mL ea hydrochloric acid dropwise ho fihlela 'mala o pinki o nyamela.[Tlhokomeliso—Karabelo e feteletseng.Lumella asiti hore e theohele ka hare ho phapu ho thibela ho phatloha.] Folisa tube, ebe u hlatsoa mahlakoreng a tube ka 20 ml ea metsi.Kenya 5.0 mL ea tharollo e tloaelehileng ea ka hare, sekoahelo, 'me u sisinyehe ho netefatsa ho kopanya hantle.Lumella tube hore e eme ho fihlela likarolo tse peli tse fapaneng li thehoa.Fetisetsa 2.5–3.5 mL ea lera le ka holimo ka har'a botlolo e loketseng ea ho arabela, 'me u kenye 2.0 mL ea pyridine e lateloa ke 2.5 mL ea N,O-bis(trimethylsilyl) trifluoroacetamide ka 1% trimethylchlorosilane.Chesa botlolo ka likhato tse 100 bakeng sa metsotso e 10.Pholile, ebe u eketsa 12 ml ea isooctane.
Sistimi ea chromatographic
(Sheba Chromatography 621, Ho Hlokahala Sistimi.)
Mokhoa: GC
Mohloli: Ionization ea mollo
Kholomo: 0.25-mm × 15-m fused-silika capillary;e koahetsoeng ka filimi ea 0.25-µm ea phase G27
Mocheso
Ente: 280
Mosireletsi: 345
Kholomo: Sheba Lethathamo la 1.
Lethathamo la 1
Thempereichara ea Pele(°) Sebaka sa Mocheso (°/min) Mocheso oa ho Qetela (°) Ho Boloka Nako ho Mocheso oa ho Qetela (min)
260 20 340 1
Khase e tsamaisang thepa: Helium
Sekhahla sa phallo: 1.5 mL / min
Boholo ba ente: 1 µL
Mofuta oa ente: Karolelano ea ho arohana, 200: 1
Ho nepahala ha sistimi
Mohlala: Tharollo e tloaelehileng
Litlhoko tsa ho tšoaneleha
Ntlha ea ho qetela: NMT 2.0 bakeng sa tlhoro ea alpha tocopherol
Phapang e amanang le maemo: NMT 2.0% bakeng sa karo-karolelano ea sebaka sa tlhoro sa alpha tocopherol ho sebaka se ka hare se tloaelehileng sa tlhoro.
Tlhahlobo
Mehlala: Tharollo e tloaelehileng le Tharollo ea Mohlala
Bala peresente ea d-alpha tocopherol (C29H50O2) karolong ea Vitamin E Polyethylene Glycol Succinate e nkiloeng:
Sephetho = (RU/RS) × (WS/WU) × 100
RU = karo-karolelano ea maemo a ka hare (sebaka se phahameng sa alpha tocopherol / sebaka se phahameng sa tekanyo ea ka hare) ho tsoa ho Sample solution
RS= karo-karolelano ea maemo a ka hare (sebaka se phahameng sa alpha tocopherol/sehlohlolo sa boemo ba ka hare) ho tsoa ho Tharollo e Tloaelehileng
WS= boima ba USP Alpha Tocopherol RS bo sebelisitsoeng ho lokisa tharollo e tloaelehileng (mg)
WU= boima ba Vitamin E Polyethylene Glycol Succinate e nkiloeng ho lokisa Sample solution (mg)
Mekhoa ea ho amohela: NLT 25.0%
LITEKO TSEKO
• Optical Rotation, Specific Rotation 781S
[Tlhokomeliso-Teko ena e supa d-alpha tocopherol kamora saponification.]
Tharollo ea mohlala: Fetisetsa 0.9 g ea Vitamin E Polyethylene Glycol Succinate, e qhibilihisitsoeng ho 60, ho tube e loketseng ea teko e kentsoeng cap, 'me u qhale ka 10.0 mL ea tai.Beha tube ka har'a sebaka sa ho futhumatsa se behiloeng ho 100-105.[Hlokomela-Reflux tharollo ka bonolo ntle le tlhahiso ea litaba.] Ha sampuli e qhibiliha ka ho feletseng, eketsa 2-3 pellets ea sodium hydroxide, 'me u tsoele pele ho reflux bakeng sa 30 min e eketsehileng.Tlosa tube mochesong, 'me ha likahare li ntse li chesa, fokotsa ho sebelisa phenolphthalein e le pontšo ka ho eketsa butle-butle 10 ml ea motsoako oa metsi le hydrochloric acid (1: 1) ho fihlela 'mala o pinki o nyamela.[Tlhokomeliso-Karabelo e makatsang.Lumella motsoako oa asiti hore o theohele ka hare ho tšupu ho thibela ho phatloha.] Folisa tšupu, kepisi, 'me u tsokotse ho fihlela likahare li tsoakane hantle.Kenya 25.0 mL ea heptane, cap, 'me u sisinyehe bakeng sa 1 min ho etsa bonnete ba ho kopanya hantle.Lumella tube hore e eme ho fihlela likarolo tse peli tse fapaneng li thehoa.Fetisetsa karolo e ka holimo ho tube e hloekileng, e omeletseng ea setso, ebe u eketsa 10.0 mL ea metsi ho tharollo e tsosolositsoeng.Koahela, sisinya, 'me u lumelle hore lihlopha li arohane.Fetisetsa lera le ka holimo ho tube e hloekileng, e omeletseng.Eketsa 10.0 mL ea tharollo ea potassium ferricyanide, e lokiselitsoeng ka ho qhibiliha 2 g ea potassium ferricyanide ka 10.0 mL ea 0.2 M sodium hydroxide, 'me u nkele cap.Shake ka matla bakeng sa 45 s, 'me u lumelle hore lihlopha li arohane bakeng sa 30 min.Haeba karolo e ka holimo ea heptane e hlakile, tsoela pele ka tekanyo ea ho potoloha ho itseng;haeba e sa hlaka, omella holim'a anhydrous sodium sulfate pele u tsoela pele ka tlhahlobo.[Tlhokomeliso-Sebelisa liphetho tsa tlhahlobo ea Likahare tsa Alpha Tocopherol ho bala ho potoloha ho itseng.]
Mekhoa ea ho amohela: NLT +24.0
• Ho qhibiliha ka metsing
Mohlala: 20 g ea vithamine E e qhibilihisitsoeng Polyethylene Glycol Succinate
Tlhahlobo: Beha Mohlala ka har'a sets'oants'o sa khalase holim'a sesebelisoa sa makenete.Hang-hang eketsa 80 ml ea metsi a belang ha u ntse u hlohlelletsa.Lumella ho pholile mocheso oa kamore ka ho susumetsa kamehla.
Mekhoa ea ho amohela: Tharollo e hlaka nakong ea 3 h.
• Boleng ba Asiti
Mohlala: 1 g ea Vithamine E Polyethylene Glycol Succinate
Analysis: Qhala Mohlala ka 25 mL ea motsoako oa joala le ether (1: 1) e seng e sa sebetse ho phenolphthalein ka 0.1 N sodium hydroxide.Eketsa 0.5 mL ea phenolphthalein TS, 'me titrate ka 0.10 N sodium hydroxide ho fihlela tharollo e sala e le pinki e fokolang ka mor'a ho sisinyeha bakeng sa 30 s.
Mokhoa oa ho amohela: NMT 0.027 mEq/g, e lekanang le NMT 0.27 mL ea 0.10 N sodium hydroxide
KEKELETSO LIHLOKO
• Sephutheloana le Polokeho: Boloka ka har’a linkho tse thata, ’me u boloke litšireletseho hore li se ke tsa khanya.
• Ho ngola: Leibole le bontsha dikahare tsa d-alpha tocopherol, tse hlahiswang ka mg/g.
• USP Reference Standards 11
USP Alpha Tocopherol RS
Mokhoa oa ho Reka?Ka kopo ikopanyeDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Phihlelo ea Lilemo Tse 15?Re na le boiphihlelo ba lilemo tse fetang 15 ho etsa le ho romella kantle ho naha mefuta e mengata e fapaneng ea li-intermediate tsa boleng bo holimo tsa meriana kapa lik'hemik'hale tse ntle.
Limmaraka tse ka Sehloohong?Rekisetsa 'maraka oa lapeng, Amerika Leboea, Europe, India, Korea, Japane, Australia, joalo-joalo.
Melemo?Boleng bo phahameng, theko e theko e tlaase, lits'ebeletso tsa litsebi le ts'ehetso ea tekheniki, phano e potlakileng.
BolengTiisetso?Tsamaiso e thata ea taolo ea boleng.Lisebelisoa tsa profeshenale bakeng sa tlhahlobo li kenyelletsa NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, joalo-joalo.
Mehlala?Lihlahisoa tse ngata li fana ka mehlala ea mahala bakeng sa tlhahlobo ea boleng, litšenyehelo tsa ho tsamaisa thepa li lokela ho lefshoa ke bareki.
Feme Audit?Ho amoheloa ha fektheri.Ke kopa o etse kopano esale pele.
MOQ?Ha ho MOQ.Taelo e nyenyane e amoheleha.
Nako ea thomello? Haeba ka har'a setoko, ho netefalitsoe hore ho tsamaisoa ka matsatsi a mararo.
Lipalangoang?Ka Express (FedEx, DHL), ka Moea, ka Leoatle.
Litokomane?Ka mor'a tšebeletso ea thekiso: COA, MOA, ROS, MSDS, joalo-joalo e ka fanoa.
Custom Synthesis?E ka fana ka lits'ebeletso tsa tloaelo tsa ho kopanya ho lekana hantle litlhoko tsa hau tsa lipatlisiso.
Litefiso Melao?Invoice ea Proforma e tla romelloa pele kamora netefatso ea odara, e kenyellelitseng tlhahisoleseling ea rona ea banka.Tefo ka T/T (Telex Transfer), PayPal, Western Union, joalo-joalo.
Vithamine E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) ke sehlahisoa sa maiketsetso.E fumaneha e le boka bo bosoeu ho isa ho bosehla bo bosehla E tiileng 'me e batla e se na tatso.Ho latela lik'hemik'hale, ke motsoako o entsoeng haholo-holo ka monoesterified polyethylene glycol 1000, polyethylene glycol 1000, polyethylene glycol 1000, le tocopherol ea mahala.
Vithamine E Polyethylene Glycol Succinate e 'nile ea sebelisoa haholo lipatlisisong tsa meriana, e le solubilizer, e khothalletsang ho monya, emulsifier, plasticizer le mojari oa tsamaiso ea ho fana ka lithethefatsi tse sa tsitsang kapa tse nang le mafura, tse kang ho qhalakanngoa ho tiileng, ho tsamaisa lithethefatsi ka mahlo, sejari sa intranasal. phano ea lithethefatsi, joalo-joalo E le li-additives tsa lijo.
Vithamine E Polyethylene Glycol Succinate ke motsoako o qhibilihang ka metsing oa vithamine E, o thehoa ka ho arabela sehlopha sa carboxyl sa vithamine E succinate le sehlopha sa hydroxyl sa polyethylene glycol.Hobane e na le vithamine E lipophilic sehlopha le polyethylene glycol hydrophilic nako e telele ketane, e na le thepa e ntle surfactant le solubility metsi, e leng ka haholo eketsa absorption ea lithethefatsi insoluble ka pampitšana gastrointestinal, eketseha bioavailability.
Lilemong tsa morao tjena, liphuputso tse ngata li fumane hore TPGS ha e khone ho sebelisoa feela e le lisebelisoa tsa meriana, empa hape e na le litšobotsi tse ngata tse ikhethang, e le li-absorption enhancers le li-multidrug resistance reversal agents, TPGS e ka boela ea sebelisoa ho li-prodrugs, micelles, liposomes, TPGS-copolymer. bajari ho ntlafatsa solubility, permeability le botsitso ba ho itokisa, e le ho finyella ho lokolloa butle, ho laoloang le ho lebisa tlhokomelo, ho khothalletsa ho kenngoa ha lithethefatsi.
1. Pharmaceutical - Vitamin E-TPGS e ntlafatsa haholo ho monya, bioavailability le katleho ea metsoako ea meriana (APIs)
2. Li-supplement tsa lijo - Vitamin E-TPGS e sebelisetsoa ho etsa li-supplement, haholo-holo tse entsoeng ho ntlafatsa labsorption ea vithamine E le limatlafatsi tse ling tsa lipophilic le nutraceuticals.
3. Lijo le Seno - Vithamine E-TPGS e ka sebelisoa ho matlafatsa lijo le lino, lino tsa lipapali, metsi le lero.
4. Tlhokomelo ea Botho - Vithamine E-TPGS e sebetsa e le ethanol e se nang ethanol, hypoallergenic, emulsifier e sa khopiseng / e thusang tlhokomelong ea botho le lits'ebetsong tsa litlolo.
5. Lihlahisoa tsa Phepo ea Liphoofolo - Vithamine E-TPGS e fana ka vithamine E e monyehang haholo le e fumanehang bioavailable bakeng sa liphoofolo tse sa khoneng ho monya mefuta e tloaelehileng ea vithamine E.
Vithamine E polyethylene glycol succinate ke ntho e nkiloeng ka vithamine E (tocopherol) e sebelisoang haholo-holo e le solubilizer kapa emulsifying agent ka lebaka la thepa ea eona ea surfactant.Ka mokhoa o hlophisitsoeng, ke amphipathic le hydrophilic, ho fapana le tocopherols, 'me ka hona ke motsoako o qhibilihang ka metsing o ka sebelisoang mefuteng ea meriana e kang capsules, matlapa, hot-melt extrusion, microemulsions, lihlahisoa tsa lihlooho, le parenterals.E 'ngoe ea lisebelisoa tsa bohlokoa ka ho fetisisa ke tšebeliso ea eona e le koloi ea ho fana ka litlhare tse thehiloeng ho lipid.E ka boela ea sebelisoa e le mohloli oa vithamine E. Vithamine E polyethylene glycol succinate e 'nile ea khetholloa mabapi le mokhoa oa eona oa ho sebetsa' me e ithutoa e le Pglycoprotein inhibitor.
Vithamine E polyethylene glycol succinate ha e tsamaisane le li-acid tse matla le li-alkali tse matla.
GRAS e thathamisitsoe.E kenyelelitsoe ho FDA Inactive Ingredients Database (tharollo ea ophthalmic kapa marotholi; li-capsules tsa molomo, tharollo, letlapa; tharollo ea lihlooho kapa marotholi).E kenyelelitsoe Lethathamong la Canada la Lijo tse Amohelehang tseo e seng tsa meriana.
