Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Factory High Quality
Fana ka Bohloeki bo Phahameng le Boleng bo tsitsitseng
Lebitso la lik'hemik'hale: Zoledronic Acid
CAS: 118072-93-8
Farnesyl Diphosphate e matla (FPP) Synthase Inhibitor
API Boleng bo Phahameng, Tlhahiso ea Khoebo
| Lebitso la Lik'hemik'hale | Asiti ea Zoledronic |
| Litlhaloso tse tšoanang | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid |
| Nomoro ea CAS | 118072-93-8 |
| Nomoro ea KAtse | RF-API90 |
| Boemo ba Setoko | Ka Setokong, Phatlalatso e Eketsehile ho fihla ho Makholo a Lik'hilograma |
| Foromo ea limolek'hule | C5H10N2O7P2 |
| Boima ba Molek'hule | 272.09 |
| Melting Point | 193.0~204.0℃ |
| Brand | Ruifu Chemical |
| Ntho | Litlhaloso |
| Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu |
| Boitsebiso | IR Spectrum ea sampuli e lumellana le ea litekanyetso tsa litšupiso |
| pH | 2.0~4.0 |
| Solubility | E qhibiliha hanyenyane ka har'a Tharollo ea 0.1N Sodium Hydrooxide, e Hanyenyane Hanyenyane ka Metsing le 0.1N Hydrochloric Acid, Ha e khone ho qhibiliha Ethanol |
| Lintho Tse Amanang | |
| Tšilafalo efe kapa efe ea Motho ka Mong | ≤0.10% |
| Litšila ka Kakaretso | ≤0.30% |
| Tahlehelo ka ho Omisa | 5.0%~7.0% |
| Chloride | ≤0.02% |
| Phosphite | ≤0.50% |
| Phosphate | ≤0.50% |
| Litšepe tse boima | ≤10ppm |
| Bohloeki | ≥99.7% |
| Tekanyetso ea Teko | Maemo a Khoebo |
| Tšebeliso | API, FPP Synthase Inhibitor, Hypercalcemia of Malignancy (HCM) |
Sephutheloana: Botlolo, Aluminium foil bag, Cardboard drum, 25kg/Drum, kapa ho latela tlhoko ea moreki.
Boemo ba polokelo:Boloka ka lijaneng tse koetsoeng sebakeng se phodileng le se omileng;Sireletsa khanya, mongobo le ho hlaseloa ke likokoanyana.
Zoledronic Acid (CAS 118072-93-8) ke bisphophonate e matla farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM).E thibela ho tsosolosoa ha masapo a osteoclast-mediated.E boetse e thibela pontšo ea Ras le kholo ea hlahala, 'me e baka apoptosis liseleng tsa mofetše oa pancreatic.E fetola phetoho ea epithelial-mesenchymal mme e thibela ho tsosolosoa ha lisele tsa kankere ea matsoele ka ho se sebetse ha NF-κB.Zoledronic acid e ile ea amoheloa ke US FDA ka 2001 bakeng sa phekolo ea hypercalcemia ea malignancy, complication ea metabolism e ka behang bophelo kotsing.Hypercalcemia ea malignancy e ka hlaha ho 50% ea bakuli ba fumanoeng ba e-na le mofetše oa matsoele o tsoetseng pele, myeloma e mengata, le mofets'e o fokolang oa sele ea matšoafo.Boemo bona bo hlaha ha likarolo tsa lik'hemik'hale tse hlahisoang ke hlahala li etsa hore li-osteoclasts li be matla haholo.Ha ho na le keketseho ea ho senyeha ha masapo, ho ba le ho lokolloa ha calcium ka har'a plasma ka nako e le 'ngoe.Ha k'halsiamo e phahama ka potlako, liphio ha li khone ho sebetsana le khatello e feteletseng, 'me hypercalcemia e hlaha.Zoledronic acid e fokotsa khatello ea calcium plasma ea mali ka ho thibela ho khutla ha masapo (ho thibela ts'ebetso ea osteoclastic le ho kenella ha osteoclast apoptosis).Ho feta moo, asiti ea zoledronic e amohetsoe ke US FDA bakeng sa kalafo ea myeloma e mengata le metastase ea masapo e amanang le mofetše o tiileng o thehiloeng ho hlahala (mohlala, prostrate le matšoafo).
