4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Purity > 99,0% (HPLC) Aprepitant Intermediate Factory
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Panganteur Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-hiji CAS 287930-73-8
(R)-1-[3,5-Bis(trifluorométil)fenil]étanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Ngaran Kimia | 4-Benzyl-2-Hydroxymorpholin-3-hiji |
| sinonim | 4-Benzyl-2-Hydroxy-Morpholin-3-hiji;2-Hidroksi-4-(Pénylmétil)-3-Morfolinon;Aprepitant Impurity 48;Fosaprepitant Impurity 23;Aprepitant panengah Ⅱ |
| Nomer CAS | 287930-73-8 |
| Nomer CAT | RF2660 |
| Status saham | Dina Stok, Skala Produksi Nepi ka Ton |
| Formula Molekul | C11H13NO3 |
| Beurat Molekul | 207.23 |
| Titik lebur | 134,0 nepi ka 138,0 ℃ |
| Titik didih | 441,7 ± 45,0 ℃ |
| Kapadetan | 1,292±0,06 g/cm3 |
| Kaleyuran dina Cai | DMSO (Rada), Métanol (Rada, Dipanaskeun) |
| merek | Kimia Ruifu |
| Barang | spésifikasi |
| Penampilan | Bubuk Kristal Bodas ka Pareum-Bodas |
| Purity / Métode Analisis | > 99,0% (HPLC) |
| Titik lebur | 134,0 nepi ka 138,0 ℃ |
| Cai (ku Karl Fischer) | <0,50% |
| Résidu on Ignition | <0,20% |
| Total Kotoran | <1,00% |
| Proton NMR Spéktrum | Conforms kana Struktur |
| Standar tés | Standar Perusahaan |
| Pamakéan | Panengah tina Aprepitant (CAS: 170729-80-3) Narkoba Antiemetic |
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4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), mangrupikeun perantara tina Aprepitant (CAS: 170729-80-3), dianggo salaku ubar antiemetik.Aprepitant mangrupikeun antagonis reséptor neurokinin-1 (NK-1) sareng milik agén pangobatan utah nalika kémoterapi kanker.Ieu mimiti hasil dimekarkeun ku Merck Company (Jerman).Dina Maret 2003, Administrasi Pangan sareng Narkoba AS nyatujuan éta pikeun dianggo dina pengobatan utah kémoterapi.Produk ieu gaduh pangirut selektif anu luhur pikeun manusa bari gaduh pangirut rendah kana serotonin, dopamin sareng pangirut reséptor glukokortikoid.Aprepitant, nalika digabungkeun sareng sambetan reséptor 5-HT3 (sapertos ondansetron hydrochloride) sareng dexamethasone kortikosteroid, tiasa ngirangan emesis akut anu disababkeun ku cisplatin sareng (atanapi) ditunda.Nerapkeun ubar ieu nyalira tiasa gaduh sababaraha pangaruh preventif.
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