Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Purity ≥99,5% (HPLC) Sitagliptin Fosfat Monohydrate Intermediate
Pasokan Sitagliptin Phosphate Monohydrate Related Intermediate:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Asam Trifluorophenylacetic CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Asam Butyric CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3
Ngaran Kimia | Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Asam Butyric |
sinonim | (Urang Sunda)-Sitagliptin N-Boc-Acid Impurity |
Nomer CAS | 486460-00-8 |
Nomer CAT | RF-PI1192 |
Status Saham | Dina Stok, Skala Produksi Nepi ka Ton |
Formula Molekul | C15H18F3NO4 |
Beurat Molekul | 333.31 |
Titik Lebur | 136,0 ~ 138,0 ℃ |
merek | Kimia Ruifu |
Barang | spésifikasi |
Penampilan | Bodas ka Pareum-Bodas Bubuk |
Idéntifikasi ku HPLC | Waktu Panyimpenan Sampel Saluyu sareng Standar Rujukan |
Leungitna dina Drying | ≤0,50% |
Abu Sulfat | ≤0,50% |
Logam beurat | <20ppm |
Isomer | ≤0,50% |
Zat Patali | |
Najis A | ≤0,50% |
Sagala Najis Tunggal lianna | ≤0,50% |
Total Kotoran | ≤0,50% |
Kasucian | ≥99,5% (HPLC) |
Standar tés | Standar Perusahaan |
Pamakéan | Panganteur Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Bungkusan: Botol, kantong Aluminium foil, 25kg / Karton Drum, atawa nurutkeun sarat customer urang.
Kaayaan Panyimpenan:Simpen dina wadah anu disegel dina tempat anu tiis sareng garing;Ngajaga tina cahaya sareng Uap.
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (CAS: 486460-00-8) mangrupa perantara penting pikeun persiapan sitagliptin.Sitagliptinphosphate nyaéta inhibitor dipeptidase -IV (DPP-4) munggaran anu disatujuan ku FDA taun 2006. Hal ieu dianggo pikeun pengobatan diabetes mellitus tipe II.Éta gaduh pangaruh hypoglycemic anu jelas nalika dianggo nyalira atanapi digabungkeun sareng metformin sareng pioglitazone, sareng aman pikeun dianggo, ditolerir saé, kalayan sababaraha réaksi ngarugikeun.Dina Agustus 2009, ubar ieu disatujuan ku Uni Éropa salaku ubar lini munggaran pikeun pengobatan diabetes tipe 2.Saatos 2011, hiji-hiji nagara parantos disatujuan kombinasi sitagliptin fosfat sareng inhibitor alfa glikosidase atanapi insulin.Sitagliptin fosfat mangrupikeun inhibitor dipeptidyl peptidase-IV anu disatujuan ku FDA anu munggaran dianggo dina pengobatan diabetes tipe 2 dugi ka ayeuna, kalayan nami dagang Januvia.