Lapatinib Intermediate CAS 231278-84-5 Purity >98,0% (HPLC)
Ngaran Kimia | 5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde |
sinonim | Lapatinib panengah 3;5-[4-[[3-Chloro-4-[(3-Fluorophenyl)methoxy]phenyl]amino]-6-Quinazolinyl]-2-Furancarboxaldehyde;5-[4-((3-Chloro-4-((3-Fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-Furaldehyde |
Nomer CAS | 231278-84-5 |
Status Saham | Dina Stok, Skala Produksi Nepi ka Ton |
Formula Molekul | C26H17ClFN3O3 |
Beurat Molekul | 473.90 |
Titik Lebur | 225,0 nepi ka 235,0 ℃ |
Kapadetan | 1,407±0,06 g/cm3 |
Indéks réfraktif | 1.694 |
COA & MSDS | Aya |
Asalna | Shanghai, Cina |
merek | Kimia Ruifu |
Barang | spésifikasi |
Penampilan | Bulak konéng nepi ka konéng bubuk padet |
Purity / Métode Analisis | > 98,0% (HPLC) |
Titik Lebur | 225,0 ~ 235,0 ℃ |
Leungitna dina Drying | <1,00% |
Résidu on Ignition | <0,50% |
Total Kotoran | <2.00% |
Logam beurat (sakumaha Pb) | <20ppm |
Standar tés | Standar Perusahaan |
Pamakéan | Panganteur API (CAS 388082-77-7) |
Bungkusan: Botol, kantong Aluminium foil, 25kg / Karton Drum, atawa nurutkeun sarat customer urang
Kaayaan Panyimpenan:Simpen dina wadah anu disegel dina tempat anu tiis sareng garing;Ngajaga tina cahaya sareng Uap
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5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde (CAS: 231278-84-5) mangrupa perantara API (CAS 388082-77-7 ).(CAS 388082-77-7) mangrupikeun ubar anu nargétkeun kanker payudara anu dikembangkeun ku British GlaxoSmithKline Co. Ieu mangrupikeun inhibitor tirosin kinase anu sacara efektif tiasa ngahambat kagiatan tirosin kinase tina reséptor faktor pertumbuhan épidermis manusa 1 sareng 2 (ErbB1, ErbB2).Éta unik tiasa meta dina sababaraha cara, mastikeun yén sél kanker payudara henteu tiasa nampi sinyal pertumbuhan.Éta ngahambat situs ATP EGFR (ErbB-1) intrasélular sareng HER2 (ErbB-2), nyegah fosforilasi sél tumor sareng aktivasina, ngahalangan sinyal régulasi handap ngaliwatan homogénitas sareng heterogenitas EGFR (ErbB-1) sareng HER2 (ErbB-1) dimerisasi.
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