Entecavir Monohydrate CAS 209216-23-9 Pabrik API Inféksi Hépatitis B Antiviral Kualitas Tinggi
Produsén Pasokan sareng Kamurnian Tinggi sareng Kualitas Stabil
Ngaran Kimia: Entecavir Monohydrate
CAS: 209216-23-9
Dipaké dina pengobatan Inféksi Hépatitis B
API Quality High, Produksi komérsial
Ngaran Kimia | Entecavir Monohydrate |
sinonim | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate |
Nomer CAS | 209216-23-9 |
Nomer CAT | RF-API79 |
Status saham | Dina Stok, Skala Produksi Nepi ka Ratusan Kilogram |
Formula Molekul | C12H17N5O4 |
Beurat Molekul | 295.3 |
Titik lebur | > 220 ℃ |
Kapadetan | 1.81 |
Kaayaan Pangiriman | Dikirim dina Suhu Ambient |
merek | Kimia Ruifu |
Barang | spésifikasi |
Penampilan | Bubuk kristalin bodas atanapi ampir bodas |
Kalarutan | Bébas Leyur dina Dimétilformamida, Rada Leyur dina Cai, Étanol jeung Métanol |
Idéntifikasi IR | Spéktrum sampel luyu jeung standar rujukan |
Idéntifikasi HPLC | Waktu ingetan sampel tés saluyu sareng standar rujukan |
Kandungan Cai (ku KF) | 5,5%~6,5% |
Rotasi optik husus | +24,0 ° ka +30,0 ° (DMF: MeOH = 1: 1 C = 1%) (dina zat anhidrat) |
Résidu on Ignition | ≤0,10% |
Zat Patali | |
Furoentecavir | ≤0,10% |
Entecavir 1-Epimer | ≤0,10% |
Entecavir 3-Epimer | ≤0,10% |
8-Methyoxy Entecavir | ≤0,10% |
Entecavir 4-Epimer | ≤0,10% |
8-Hydroxy Entecavir | ≤0,10% |
4-Dimétilsilil Entecavir | ≤0,10% |
Sanyawa Patali Entecavir A | ≤0,10% |
Sagala Najis Unspecified | ≤0,10% |
Total Kotoran | ≤0,30% |
Sésa pangleyur | |
Métanol | ≤600ppm |
Diklorometana | ≤300ppm |
Étil Asétat | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluén | ≤890ppm |
Bénzil klorida | ≤1000ppm |
Bénzil Alkohol | ≤1000ppm |
Wates mikroba | |
Jumlah aérobik cacah | ≤100cfu / g |
Ragi jeung Molds | ≤10cfu / g |
Escherichia Coli | Teu Kudu Dideteksi |
Logam beurat | ≤10ppm |
Assay | 98,0% ~ 102,0% (HPLC; dina dasar anhidrat) |
Ukuran partikel | 95% tina partikel kedah dina 125um |
Standar tés | Standar Perusahaan;Amérika Sarikat Pharmacopoeia (USP) Standar |
Pamakéan | Ubar antiviral dianggo dina pengobatan Inféksi Hépatitis B |
Bungkusan: Botol, kantong Aluminium foil, kardus drum, 25kg / Drum, atawa nurutkeun sarat customer urang.
Kaayaan Panyimpenan:Simpen dina wadah anu disegel dina tempat anu tiis sareng garing;Ngajaga tina cahaya, Uap jeung infestation hama.
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Entecavir Monohydrate (CAS 209216-23-9) mangrupikeun ubar antiviral lisan anu dianggo dina pengobatan inféksi Hépatitis B Virus (HBV).Entecavir Monohydrate nyaéta analog nukléosida (leuwih husus, analog guanin) nu ngahambat transkripsi sabalikna, réplikasi DNA jeung transkripsi dina vira.Ieu jenis anyar ubar cyclopentyl acyl guanosine anti-Hépatitis B virus jeung épék farmakologis sarupa Entecavir.Hal ieu sacara klinis diterapkeun pikeun pengobatan Hépatitis B kronis sawawa dimana aya réplikasi virus aktip, paningkatan sérum transaminase ALT atanapi lesi aktip anu ditingali tina histologi ati.Entecavir Monohydrate mangrupikeun inhibitor HBV anu kuat sareng selektif, kalayan EC50 3,75 nM dina sél HepG2.Entecavir mangrupakeun inhibitor transcriptase sabalikna.Éta nyegah Virus Hépatitis B (HBV) tina ngalikeun sareng ngirangan jumlah virus dina awak.
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